Human Intestinal PEPT1 Transporter Expression and Localization in Preterm and Term Infants

M. G. Mooij; B. E. A. de Koning; D. J. Lindenbergh-Kortleve; Y. Simons-Oosterhuis; B. D. van Groen; D. Tibboel; J. N. Samsom; S. N. de Wildt

doi:10.1124/dmd.115.068809

Human Intestinal PEPT1 Transporter Expression and Localization in Preterm and Term Infants

Drug Metabolism and Disposition ◽

10.1124/dmd.115.068809 ◽

2016 ◽

Vol 44 (7) ◽

pp. 1014-1019 ◽

Cited By ~ 24

Author(s):

M. G. Mooij ◽

B. E. A. de Koning ◽

D. J. Lindenbergh-Kortleve ◽

Y. Simons-Oosterhuis ◽

B. D. van Groen ◽

...

Keyword(s):

Term Infants ◽

Pept1 Transporter ◽

Transporter Expression

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Neural activation in mothers of preterm and full-term infants: Preliminary findings from a 3T fMRI study

PsycEXTRA Dataset ◽

10.1037/e579192013-354 ◽

2012 ◽

Author(s):

R. Montirosso ◽

S. Moriconi ◽

B. Riccardi ◽

G. Reni ◽

F. Arrigoni ◽

...

Keyword(s):

Full Term ◽

Neural Activation ◽

Term Infants ◽

Fmri Study

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LXR und ABC-Transporter-Expression im Trophoblasten bei IUGR

Geburtshilfe und Frauenheilkunde ◽

10.1055/s-0037-1600072 ◽

2017 ◽

Vol 77 (04) ◽

pp. 379-395

Author(s):

L Schmieding ◽

A Klein ◽

N Maass ◽

C Eckmann-Scholz ◽

D Lütjohann ◽

...

Keyword(s):

Abc Transporter ◽

Transporter Expression

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The Platelet of the Newborn Infant – Adenine Nucleotide Metabolism and Release

Thrombosis and Haemostasis ◽

10.1055/s-0038-1650026 ◽

1980 ◽

Vol 43 (02) ◽

pp. 099-103 ◽

Cited By ~ 9

Author(s):

J M Whaun ◽

P Lievaart ◽

Keyword(s):

Newborn Infant ◽

Adenine Nucleotide ◽

Platelet Rich Plasma ◽

Adenine Nucleotides ◽

Newborn Infants ◽

Specific Radioactivity ◽

Nucleotide Metabolism ◽

Breakdown Product ◽

Term Infants ◽

Adenine Nucleotide Metabolism

SummaryBlood from normal full term infants, mothers and normal adults was collected in citrate. Citrated platelet-rich plasma was prelabelled with 3H-adenine and reacted with release inducers, collagen and adrenaline. Adenine nucleotide metabolism, total adenine nucleotide levels and changes in sizes of these pools were determined in platelets from these three groups of subjects.At rest, the platelet of the newborn infant, compared to that of the mother and normal adult, possessed similar amounts of adenosine triphosphate (ATP), 4.6 ± 0.2 (SD), 5.0 ± 1.1, 4.9 ± 0.6 µmoles ATP/1011 platelets respectively, and adenosine diphosphate (ADP), 2.4 ± 0.7, 2.8 ± 0.6, 3.0 ± 0.3 umoles ADP/1011 platelets respectively. However the marked elevation of specific radioactivity of ADP and ATP in these resting platelets indicated the platelet of the neonate has decreased adenine nucleotide stores.In addition to these decreased stores of adenine nucleotides, infant platelets showed significantly impaired release of ADP and ATP on exposure to collagen. The release of ADP in infants, mothers, and other adults was 0.9 ± 0.5 (SD), 1.5 ± 0.5, 1.5 ± 0.1 umoles/1011 platelets respectively; that of ATP was 0.6 ± 0.3, 1.0 ± 0.1,1.3 ± 0.2 µmoles/1011 platelets respectively. With collagen-induced release, platelets of newborn infants compared to those of other subjects showed only slight increased specific radioactivities of adenine nucleotides over basal levels. The content of metabolic hypoxanthine, a breakdown product of adenine nucleotides, increased in both platelets and plasma in all subjects studied.In contrast, with adrenaline as release inducer, the platelets of the newborn infant showed no adenine nucleotide release, no change in total ATP and level of radioactive hypoxanthine, and minimal change in total ADP. The reason for this decreased adrenaline reactivity of infant platelets compared to reactivity of adult platelets is unknown.Infant platelets may have different membranes, with resulting differences in regulation of cellular processes, or alternatively, may be refractory to catecholamines because of elevated levels of circulating catecholamines in the newborn period.

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