scholarly journals Dose of Phenobarbital and Age of Treatment at Early Life are Two Key Factors for the Persistent Induction of Cytochrome P450 Enzymes in Adult Mouse Liver

2015 ◽  
Vol 43 (12) ◽  
pp. 1938-1945 ◽  
Author(s):  
Yun-Chen Tien ◽  
Ke Liu ◽  
Chad Pope ◽  
Pengcheng Wang ◽  
Xiaochao Ma ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Early Life ◽  
Mouse Liver ◽  
Adult Mouse ◽  
Cytochrome P450 Enzymes ◽  
Key Factors ◽  
Adult Mouse Liver

AN IMPROVED METHOD FOR CHROMOSOME PREPARATION FROM MOUSE LIVER

1971 ◽  
Vol 13 (3) ◽  
pp. 612-617 ◽  
Author(s):  
N. C. Sun ◽  
E. H. Y. Chu
Keyword(s):  
Mitotic Activity ◽  
Subcutaneous Injection ◽  
Mouse Liver ◽  
Adult Mouse ◽  
Regenerating Liver ◽  
Improved Method ◽  
Mitotic Chromosomes ◽  
Simple Method ◽  
Cytogenetic Analyses ◽  
Adult Mouse Liver

A simple method for preparing mitotic chromosomes from adult mouse liver is described. The procedure involves the accumulation of metaphases in regenerating liver resulting from CCI4 treatment, followed by Trypsin perfusion, hypotonic pretreatment and fixation of cells, and flame-drying of slides to spread chromosomes. Approximately 2 × 106 intact liver cells can be obtained from a single mouse liver – enough to prepare 50 slides. A peak mitotic activity, with more than 1% of cells in mitosis, was observed 72 hr after subcutaneous injection of 0.1 ml of 45% CCI4 per animal. The distribution of diploid, tetraploid, and octaploid cells in mitosis was about 86, 11, and 3%, respectively. The abundant number of analyzable metaphases in such preparations makes this method valuable for cytogenetic analyses of normally non-proliferating tissue from adult laboratory mammals.

scholarly journals Acetaminophen-Induced Liver Injury Alters Expression and Activities of Cytochrome P450 Enzymes in an Age-Dependent Manner in Mouse Liver

2020 ◽  
Vol 48 (5) ◽  
pp. 326-336 ◽  
Author(s):  
Yifan Bao ◽  
Pei Wang ◽  
Xueyan Shao ◽  
Junjie Zhu ◽  
Jingcheng Xiao ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Liver Injury ◽  
Mouse Liver ◽  
Dependent Manner ◽  
Cytochrome P450 Enzymes ◽  
Age Dependent

Functional liver tissue engineering by an adult mouse liver-derived neuro-glia antigen 2-expressing stem/progenitor population

2017 ◽  
Vol 12 (1) ◽  
pp. e190-e202 ◽  
Author(s):  
Hongyu Zhang ◽  
Christopher T. Siegel ◽  
Jing Li ◽  
Jiejuan Lai ◽  
Ling Shuai ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Liver Tissue ◽  
Mouse Liver ◽  
Adult Mouse ◽  
Liver Tissue Engineering ◽  
Adult Mouse Liver
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