Influence of ABCB1 Genotype in Collies on the Pharmacokinetics and Pharmacodynamics of Loperamide in a Dose-Escalation Study

Michael J. Myers; Marilyn Martinez; Hui Li; Junshan Qiu; Lisa Troutman; Michele Sharkey; Haile F. Yancy

doi:10.1124/dmd.115.063735

Influence of ABCB1 Genotype in Collies on the Pharmacokinetics and Pharmacodynamics of Loperamide in a Dose-Escalation Study

Drug Metabolism and Disposition ◽

10.1124/dmd.115.063735 ◽

2015 ◽

Vol 43 (9) ◽

pp. 1392-1407 ◽

Cited By ~ 5

Author(s):

Michael J. Myers ◽

Marilyn Martinez ◽

Hui Li ◽

Junshan Qiu ◽

Lisa Troutman ◽

...

Keyword(s):

Dose Escalation ◽

Pharmacokinetics And Pharmacodynamics ◽

Dose Escalation Study ◽

Abcb1 Genotype

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P2-476: A Phase 1, dose escalation study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of multiple oral daily doses of ELND006 in healthy elderly subjects

Alzheimer s & Dementia ◽

10.1016/j.jalz.2011.05.1347 ◽

2011 ◽

Vol 7 ◽

pp. S465-S465 ◽

Cited By ~ 3

Author(s):

Earvin Liang ◽

Wenzhong Jerry Liu ◽

Lisa Lohr ◽

Van Nguyen ◽

Holly Lin ◽

...

Keyword(s):

Dose Escalation ◽

Phase 1 ◽

Elderly Subjects ◽

Pharmacokinetics And Pharmacodynamics ◽

Dose Escalation Study ◽

Healthy Elderly ◽

Healthy Elderly Subjects

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A Randomized Dose-Escalation Study on the Safety, Tolerability, Immunogenicity, Pharmacokinetics and Pharmacodynamics of a Novel Recombinant Human Albumin in Healthy Subjects

European Journal of Pharmaceutical Sciences ◽

10.1016/j.ejps.2021.105923 ◽

2021 ◽

pp. 105923

Author(s):

Cuiyun Li ◽

Wei Xiang ◽

Min Wu ◽

Hong Zhang ◽

Jianqiu Cheng ◽

...

Keyword(s):

Dose Escalation ◽

Healthy Subjects ◽

Human Albumin ◽

Pharmacokinetics And Pharmacodynamics ◽

Dose Escalation Study ◽

Recombinant Human Albumin

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358 A Multi-arm Phase 1 Dose Escalation Study of Safety, Pharmacokinetics, and Pharmacodynamics of the Dual PI3K/mTOR Inhibitors PF-04691502 (oral) and PF-05212384 (IV) in Combination with the MEK Inhibitor PD-0325901 or Irinotecan in Patients with Advanced Cancer

European Journal of Cancer ◽

10.1016/s0959-8049(12)72156-1 ◽

2012 ◽

Vol 48 ◽

pp. 109 ◽

Cited By ~ 8

Author(s):

C. Britten ◽

Z. Wainberg ◽

J. Tabernero ◽

M. Alsina Maqueda ◽

S. Leong ◽

...

Keyword(s):

Advanced Cancer ◽

Dose Escalation ◽

Phase 1 ◽

Mtor Inhibitors ◽

Mek Inhibitor ◽

Pharmacokinetics And Pharmacodynamics ◽

Dose Escalation Study

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A single blind, placebo controlled, across groups dose escalation study of the safety, tolerability, pharmacokinetics and pharmacodynamics of the melatonin analog β-methyl-6-chloromelatonin

Life Sciences ◽

10.1016/j.lfs.2004.03.023 ◽

2004 ◽

Vol 75 (15) ◽

pp. 1843-1856 ◽

Cited By ~ 32

Author(s):

J.J Mulchahey ◽

D.R Goldwater ◽

F.P Zemlan

Keyword(s):

Dose Escalation ◽

Pharmacokinetics And Pharmacodynamics ◽

Dose Escalation Study ◽

Single Blind

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A phase I, randomized, double‐blind, placebo‐controlled, single‐ and multiple dose escalation study evaluating the safety, pharmacokinetics and pharmacodynamics of VX‐128, a highly selective Na v 1.8 inhibitor, in healthy adults

Clinical and Translational Science ◽

10.1111/cts.13215 ◽

2021 ◽

Author(s):

Hemme J. Hijma ◽

Emilie M. J. Brummelen ◽

Pieter S. Siebenga ◽

Geert Jan Groeneveld

Keyword(s):

Phase I ◽

Dose Escalation ◽

Multiple Dose ◽

Healthy Adults ◽

Pharmacokinetics And Pharmacodynamics ◽

Dose Escalation Study ◽

Double Blind ◽

Double Blind Placebo

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Dose-escalation study of the pharmacokinetics and pharmacodynamics of rivaroxaban in healthy elderly subjects

Current Medical Research and Opinion ◽

10.1185/03007990802361499 ◽

2008 ◽

Vol 24 (10) ◽

pp. 2757-2765 ◽

Cited By ~ 172

Author(s):

Dagmar Kubitza ◽

Michael Becka ◽

Angelika Roth ◽

Wolfgang Mueck

Keyword(s):

Dose Escalation ◽

Elderly Subjects ◽

Pharmacokinetics And Pharmacodynamics ◽

Dose Escalation Study ◽

Healthy Elderly ◽

Healthy Elderly Subjects

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First-in-Human, Phase I Dose-Escalation Study of the Safety, Pharmacokinetics, and Pharmacodynamics of RO5126766, a First-in-Class Dual MEK/RAF Inhibitor in Patients with Solid Tumors

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-12-0742 ◽

2012 ◽

Vol 18 (17) ◽

pp. 4806-4819 ◽

Cited By ~ 96

Author(s):

Maria Martinez-Garcia ◽

Udai Banerji ◽

Joan Albanell ◽

Rastilav Bahleda ◽

Saoirse Dolly ◽

...

Keyword(s):

Phase I ◽

Solid Tumors ◽

Dose Escalation ◽

Pharmacokinetics And Pharmacodynamics ◽

Dose Escalation Study

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Crossover Dose Escalation Study to Assess Safety, Pharmacokinetics, and Pharmacodynamics of Single Doses of R1663, an Oral Factor Xa Inhibitor, in Healthy Male Volunteers

The Journal of Clinical Pharmacology ◽

10.1177/0091270011401621 ◽

2012 ◽

Vol 52 (4) ◽

pp. 499-510 ◽

Cited By ~ 5

Author(s):

Christophe Schmitt ◽

Anne Pannier ◽

Christine McIntyre ◽

Hagen Zandt ◽

Cornelia Ciorciaro ◽

...

Keyword(s):

Dose Escalation ◽

Factor Xa ◽

Factor Xa Inhibitor ◽

Healthy Male ◽

Pharmacokinetics And Pharmacodynamics ◽

Dose Escalation Study ◽

Healthy Male Volunteers ◽

Male Volunteers

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Safety, Pharmacokinetics, and Pharmacodynamics of Trazpiroben (TAK‐906), a Novel Selective D 2 /D 3 Receptor Antagonist: A Phase 1 Randomized, Placebo‐Controlled Single‐ and Multiple‐Dose Escalation Study in Healthy Participants

Clinical Pharmacology in Drug Development ◽

10.1002/cpdd.906 ◽

2021 ◽

Author(s):

Roger L. Whiting ◽

Borje Darpo ◽

Chunlin Chen ◽

Margaret Fletcher ◽

Dan Combs ◽

...

Keyword(s):

Receptor Antagonist ◽

Dose Escalation ◽

Multiple Dose ◽

Phase 1 ◽

Pharmacokinetics And Pharmacodynamics ◽

Dose Escalation Study ◽

Healthy Participants

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Phase I dose-escalation study to determine the safety, pharmacokinetics and pharmacodynamics of brivanib alaninate in combination with full-dose cetuximab in patients with advanced gastrointestinal malignancies who have failed prior therapy

British Journal of Cancer ◽

10.1038/bjc.2011.182 ◽

2011 ◽

Vol 105 (1) ◽

pp. 44-52 ◽

Cited By ~ 23

Author(s):

C R Garrett ◽

L L Siu ◽

A El-Khoueiry ◽

J Buter ◽

C M Rocha-Lima ◽

...

Keyword(s):

Phase I ◽

Dose Escalation ◽

Pharmacokinetics And Pharmacodynamics ◽

Dose Escalation Study ◽

Gastrointestinal Malignancies ◽

Full Dose ◽

Prior Therapy ◽

Brivanib Alaninate

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