Mechanistic Understanding of Translational Pharmacokinetic-Pharmacodynamic Relationships in Nonclinical Tumor Models: A Case Study of Orally Available Novel Inhibitors of Anaplastic Lymphoma Kinase

2014 ◽  
Vol 43 (1) ◽  
pp. 54-62 ◽  
Author(s):  
Shinji Yamazaki ◽  
Justine L Lam ◽  
Helen Y Zou ◽  
Hui Wang ◽  
Tod Smeal ◽  
...  
Keyword(s):  
Anaplastic Lymphoma Kinase ◽  
Tumor Models ◽  
Anaplastic Lymphoma ◽  
Mechanistic Understanding

Importance of protein flexibility in molecular recognition: a case study on Type-I1/2 inhibitors of ALK

2018 ◽  
Vol 20 (7) ◽  
pp. 4851-4863 ◽  
Author(s):  
Xiaotian Kong ◽  
Huiyong Sun ◽  
Peichen Pan ◽  
Feng Zhu ◽  
Shan Chang ◽  
...  
Keyword(s):  
Molecular Recognition ◽  
Anaplastic Lymphoma Kinase ◽  
Protein Flexibility ◽  
Anaplastic Lymphoma ◽  
Promising Target

Anaplastic lymphoma kinase (ALK) has been regarded as a promising target for the therapy of various cancers.

scholarly journals Sinonasal Inflammatory Myofibroblastic Tumor with Anaplastic Lymphoma Kinase 1 Rearrangement: Case Study and Literature Review

2016 ◽  
Vol 11 (2) ◽  
pp. 131-138 ◽  
Author(s):  
Ghizlene Lahlou ◽  
Marion Classe ◽  
Michel Wassef ◽  
Pierre-Alexandre Just ◽  
Nicolas Le Clerc ◽  
...  
Keyword(s):  
Literature Review ◽  
Anaplastic Lymphoma Kinase ◽  
Inflammatory Myofibroblastic Tumor ◽  
Anaplastic Lymphoma

Anaplastic Lymphoma Kinase in Human Cancer

2012 ◽  
Vol 17 (2) ◽  
pp. 123-143 ◽  
Author(s):  
Christina Schonherr ◽  
Bengt Hallberg ◽  
Ruth Palmer
Keyword(s):  
Anaplastic Lymphoma Kinase ◽  
Human Cancer ◽  
Anaplastic Lymphoma
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