Validation of uPA/SCID Mouse with Humanized Liver as a Human Liver Model: Protein Quantification of Transporters, Cytochromes P450, and UDP-Glucuronosyltransferases by LC-MS/MS

Sumio Ohtsuki; Hirotaka Kawakami; Tae Inoue; Kenji Nakamura; Chise Tateno; Yuki Katsukura; Wataru Obuchi; Yasuo Uchida; Junichi Kamiie; Toru Horie; Tetsuya Terasaki

doi:10.1124/dmd.114.057646

Validation of uPA/SCID Mouse with Humanized Liver as a Human Liver Model: Protein Quantification of Transporters, Cytochromes P450, and UDP-Glucuronosyltransferases by LC-MS/MS

Drug Metabolism and Disposition ◽

10.1124/dmd.114.057646 ◽

2014 ◽

Vol 42 (6) ◽

pp. 1039-1043 ◽

Cited By ~ 20

Author(s):

Sumio Ohtsuki ◽

Hirotaka Kawakami ◽

Tae Inoue ◽

Kenji Nakamura ◽

Chise Tateno ◽

...

Keyword(s):

Human Liver ◽

Scid Mouse ◽

Cytochromes P450 ◽

Protein Quantification ◽

Liver Model ◽

Model Protein

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Simultaneous Absolute Protein Quantification of Transporters, Cytochromes P450, and UDP-Glucuronosyltransferases as a Novel Approach for the Characterization of Individual Human Liver: Comparison with mRNA Levels and Activities

Drug Metabolism and Disposition ◽

10.1124/dmd.111.042259 ◽

2011 ◽

Vol 40 (1) ◽

pp. 83-92 ◽

Cited By ~ 284

Author(s):

Sumio Ohtsuki ◽

Olaf Schaefer ◽

Hirotaka Kawakami ◽

Tae Inoue ◽

Stephanie Liehner ◽

...

Keyword(s):

Human Liver ◽

Cytochromes P450 ◽

Protein Quantification ◽

Mrna Levels ◽

Novel Approach ◽

Individual Human

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Interaction of isoflavonoids with human liver microsomal cytochromes P450: inhibition of CYP enzyme activities

Xenobiotica ◽

10.1080/00498254.2016.1195028 ◽

2016 ◽

Vol 47 (4) ◽

pp. 324-331 ◽

Cited By ~ 15

Author(s):

Michaela Kopečná-Zapletalová ◽

Kristýna Krasulová ◽

Pavel Anzenbacher ◽

Petr Hodek ◽

Eva Anzenbacherová

Keyword(s):

Enzyme Activities ◽

Human Liver ◽

Cytochromes P450

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Multiple-Approaches to the Identification and Quantification of Cytochromes P450 in Human Liver Tissue by Mass Spectrometry

Journal of Proteome Research ◽

10.1021/pr800795r ◽

2009 ◽

Vol 8 (4) ◽

pp. 1672-1681 ◽

Cited By ~ 44

Author(s):

Cathrin Seibert ◽

Brian R. Davidson ◽

Barry J. Fuller ◽

Laurence H. Patterson ◽

William J. Griffiths ◽

...

Keyword(s):

Mass Spectrometry ◽

Liver Tissue ◽

Human Liver ◽

Cytochromes P450 ◽

Human Liver Tissue ◽

Identification And Quantification

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Interaction of Sulfaphenazole Derivatives with Human Liver Cytochromes P450 2C: Molecular Origin of the Specific Inhibitory Effects of Sulfaphenazole on CYP 2C9 and Consequences for the Substrate Binding Site Topology of CYP 2C9

Biochemistry ◽

10.1021/bi961950t ◽

1996 ◽

Vol 35 (50) ◽

pp. 16205-16212 ◽

Cited By ~ 88

Author(s):

Annah Mancy ◽

Sylvie Dijols ◽

Sonia Poli ◽

F. Peter Guengerich ◽

Daniel Mansuy

Keyword(s):

Binding Site ◽

Human Liver ◽

Cytochromes P450 ◽

Substrate Binding ◽

Inhibitory Effects ◽

Substrate Binding Site ◽

Molecular Origin

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INTERACTION OF AROMATIC CYTOKININS WITH HUMAN LIVER MICROSOMAL CYTOCHROMES P450

Biomedical Papers ◽

10.5507/bp.2005.056 ◽

2005 ◽

Vol 149 (2) ◽

pp. 349-351 ◽

Cited By ~ 2

Author(s):

Eva Anzenbacherova ◽

Jakub Janalik ◽

Igor Popa ◽

Miroslav Strnad ◽

Pavel Anzenbacher

Keyword(s):

Human Liver ◽

Cytochromes P450 ◽

Aromatic Cytokinins

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Numerical analysis of fractional human liver model in fuzzy environment

Journal of Taibah University for Science ◽

10.1080/16583655.2021.2006894 ◽

2021 ◽

Vol 15 (1) ◽

pp. 840-851

Author(s):

Shabir Ahmad ◽

Aman Ullah ◽

Ali Akgül ◽

Thabet Abdeljawad

Keyword(s):

Numerical Analysis ◽

Human Liver ◽

Fuzzy Environment ◽

Liver Model

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A Human Liver Model of Metabolism as a Tool in the Identification of Potential PET Radiotracers 1 1Transcripts of the BRAINPET97 discussion of this chapter can be found in Section VIII.

Quantitative Functional Brain Imaging with Positron Emission Tomography ◽

10.1016/b978-012161340-2/50044-5 ◽

1998 ◽

pp. 279-283 ◽

Cited By ~ 1

Author(s):

A.A. WILSON ◽

T. INABA ◽

N. FISCHER ◽

J.N. DASILVA ◽

S. HOULE

Keyword(s):

Human Liver ◽

Liver Model ◽

Section Viii ◽

Pet Radiotracers

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O.053 The human liver uPA-SCID mouse, a preclinical model to test anti-hepatitis C compounds

Journal of Clinical Virology ◽

10.1016/s1386-6532(06)80060-0 ◽

2006 ◽

Vol 36 ◽

pp. S16-S17

Author(s):

T. Vanwolleghem ◽

P. Meuleman ◽

R. De Vos ◽

L. Libbrecht ◽

T. Roskams ◽

...

Keyword(s):

Hepatitis C ◽

Human Liver ◽

Scid Mouse ◽

Preclinical Model

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Interindividual variation in the isomerization of 4- hydroxytamoxifen by human liver microsomes: involvement of cytochromes P450

Carcinogenesis ◽

10.1093/carcin/15.12.2733 ◽

1994 ◽

Vol 15 (12) ◽

pp. 2733-2738 ◽

Cited By ~ 29

Author(s):

M.L. Williams ◽

M. S. Lennard ◽

I. J. Martin ◽

G. T. Tucker

Keyword(s):

Human Liver ◽

Cytochromes P450 ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

Interindividual Variation

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IN VITRO METABOLISM OF THE CALMODULIN ANTAGONIST DY-9760e (3-[2-[4-(3-CHLORO-2-METHYLPHENYL)-1-PIPERAZINYL]ETHYL]-5,6-DIMETHOXY-1-(4-IMIDAZOLYLMETHYL)-1H-INDAZOLE DIHYDROCHLORIDE 3.5 HYDRATE) BY HUMAN LIVER MICROSOMES: INVOLVEMENT OF CYTOCHROMES P450 IN ATYPICAL KINETICS AND POTENTIAL DRUG INTERACTIONS

Drug Metabolism and Disposition ◽

10.1124/dmd.105.004903 ◽

2005 ◽

Vol 33 (11) ◽

pp. 1628-1636 ◽

Cited By ~ 5

Author(s):

Shuko Tachibana ◽

Yuko Fujimaki ◽

Hiroyuki Yokoyama ◽

Osamu Okazaki ◽

Ken-ichi Sudo

Keyword(s):

Drug Interactions ◽

Human Liver ◽

Cytochromes P450 ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

In Vitro Metabolism ◽

Potential Drug ◽

Calmodulin Antagonist

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