scholarly journals The Role of Cytochrome P450–Dependent Metabolism in the Regulation of Mouse Hepatic Growth Hormone Signaling Components and Target Genes by 3-Methylcholanthrene

2012 ◽  
Vol 41 (2) ◽  
pp. 457-465 ◽  
Author(s):  
Chunja Lee ◽  
Xinxin Ding ◽  
David S. Riddick
Keyword(s):  
Growth Hormone ◽  
Cytochrome P450 ◽  
Target Genes ◽  
Hormone Signaling ◽  
Signaling Components

scholarly journals Aryl hydrocarbon receptor-dependence of dioxin’s effects on constitutive mouse hepatic cytochromes P450 and growth hormone signaling components

2012 ◽  
Vol 90 (10) ◽  
pp. 1354-1363 ◽  
Author(s):  
Chunja Lee ◽  
David S. Riddick
Keyword(s):  
Growth Hormone ◽  
Cytochrome P450 ◽  
Aryl Hydrocarbon Receptor ◽  
Target Genes ◽  
Janus Kinase ◽  
Specific Gene ◽  
Mrna Levels ◽  
Dependent Manner ◽  
Aryl Hydrocarbon ◽  
Signaling Components

The aryl hydrocarbon receptor (AHR) has physiological roles in the absence of exposure to exogenous ligands, and mediates adaptive and toxic responses to the environmental pollutant 2,3,7,8-tetracholorodibenzo-p-dioxin (TCDD). A readily metabolized AHR agonist, 3-methylcholanthrene, disrupts the expression of mouse hepatic growth hormone (GH) signaling components and suppresses cytochrome P450 2D9 (Cyp2d9), a male-specific gene controlled by pulsatile GH via signal transducer and activator of transcription 5b (STAT5b). Using TCDD as an essentially nonmetabolized AHR agonist, and Ahr −/− mice as the preferred model to determine the AHR-dependence of biological responses, we now show that 2 mouse hepatic STAT5b target genes, Cyp2d9, and major urinary protein 2 (Mup2), are suppressed by TCDD in an AHR-dependent manner. TCDD also decreased hepatic mRNA levels for GH receptor, Janus kinase 2, and STAT5a/b with AHR-dependence. Without inducing selected hepatic inflammatory markers, TCDD caused AHR-dependent induction of Cyp1a1 and NADPH-cytochrome P450 oxidoreductase (Por) and suppression of Cyp3a11. In vehicle-treated mice, basal mRNA levels for CYP2D9, CYP3A11, POR, serum amyloid protein P, and MUP2 were influenced by Ahr genetic status. We conclude that AHR activation per se leads to dysregulation of hepatic GH signaling components and suppression of some, but not all, STAT5b target genes.

scholarly journals PIF4 and PIF4-Interacting Proteins: At the Nexus of Plant Light, Temperature and Hormone Signal Integrations

2021 ◽  
Vol 22 (19) ◽  
pp. 10304
Author(s):  
Yang Xu ◽  
Ziqiang Zhu
Keyword(s):  
Target Genes ◽  
High Ambient Temperature ◽  
Interacting Proteins ◽  
Hormone Signaling ◽  
Helix Loop Helix ◽  
Robust Network ◽  
Global Transcriptome ◽  
Signaling Components ◽  
Reduce Gene Expression ◽  
Gene Expression Levels

Basic helix-loop-helix (bHLH) family transcription factor PHYTOCHROME INTERACTING FACTOR 4 (PIF4) is necessary for plant adaption to light or high ambient temperature. PIF4 directly associates with plenty of its target genes and modulates the global transcriptome to induce or reduce gene expression levels. However, PIF4 activity is tightly controlled by its interacting proteins. Until now, twenty-five individual proteins have been reported to physically interact with PIF4. These PIF4-interacting proteins act together with PIF4 and form a unique nexus for plant adaption to light or temperature change. In this review, we will discuss the different categories of PIF4-interacting proteins, including photoreceptors, circadian clock regulators, hormone signaling components, and transcription factors. These distinct PIF4-interacting proteins either integrate light and/or temperature cues with endogenous hormone signaling, or control PIF4 abundances and transcriptional activities. Taken together, PIF4 and PIF4-interacting proteins play major roles for exogenous and endogenous signal integrations, and therefore establish a robust network for plants to cope with their surrounding environmental alterations.

Regulation of Constitutive Mouse Hepatic Cytochromes P450 and Growth Hormone Signaling Components by 3-Methylcholanthrene

2006 ◽  
Vol 34 (9) ◽  
pp. 1530-1538 ◽  
Author(s):  
Chunja Lee ◽  
Janine R. Hutson ◽  
Vivien Kok-Fung Tzau ◽  
David S. Riddick
Keyword(s):  
Growth Hormone ◽  
Cytochromes P450 ◽  
Hormone Signaling ◽  
Signaling Components

Role of glucose utilization in the restoration of hypophysectomy-induced hepatic cytochrome P450 2E1 by growth hormone in rats

2000 ◽  
Vol 127 (1) ◽  
pp. 13-28 ◽  
Author(s):  
Moon Ho Son ◽  
Keon Wook Kang ◽  
Eun Jung Kim ◽  
Ji Hwa Ryu ◽  
Hyeon Cho ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Cytochrome P450 ◽  
Glucose Utilization ◽  
Cytochrome P450 2E1 ◽  
Hepatic Cytochrome

scholarly journals The Role of Receptor Dimerization Domain Residues in Growth Hormone Signaling

1997 ◽  
Vol 272 (8) ◽  
pp. 5133-5140 ◽  
Author(s):  
Changmin Chen ◽  
Ross Brinkworth ◽  
Michael J. Waters
Keyword(s):  
Growth Hormone ◽  
Hormone Signaling ◽  
Dimerization Domain ◽  
Receptor Dimerization

scholarly journals The role of STAT proteins in growth hormone signaling

Oncogene ◽  
2000 ◽  
Vol 19 (21) ◽  
pp. 2585-2597 ◽  
Author(s):  
James Herrington ◽  
Lisa S Smit ◽  
Jessica Schwartz ◽  
Christin Carter-Su
Keyword(s):  
Growth Hormone ◽  
Hormone Signaling ◽  
Stat Proteins

The Role of Growth Hormone Signaling in the Control of Ageing

2004 ◽  
pp. 123-137 ◽  
Author(s):  
A. Bartke ◽  
M. Heiman ◽  
D. Turyn ◽  
F. Dominici ◽  
J.J. Kopchick
Keyword(s):  
Growth Hormone ◽  
Hormone Signaling
Sign in / Sign up

Export Citation Format

Share Document