Time-Dependent Inhibition and Estimation of CYP3A Clinical Pharmacokinetic Drug-Drug Interactions Using Plated Human Cell Systems

Daniel R. Albaugh; Cody L. Fullenwider; Michael B. Fisher; J. Matthew Hutzler

doi:10.1124/dmd.112.044644

Time-Dependent Inhibition and Estimation of CYP3A Clinical Pharmacokinetic Drug-Drug Interactions Using Plated Human Cell Systems

Drug Metabolism and Disposition ◽

10.1124/dmd.112.044644 ◽

2012 ◽

Vol 40 (7) ◽

pp. 1336-1344 ◽

Cited By ~ 14

Author(s):

Daniel R. Albaugh ◽

Cody L. Fullenwider ◽

Michael B. Fisher ◽

J. Matthew Hutzler

Keyword(s):

Drug Interactions ◽

Clinical Pharmacokinetic ◽

Human Cell ◽

Time Dependent ◽

Cell Systems ◽

Dependent Inhibition ◽

Time Dependent Inhibition ◽

Pharmacokinetic Drug

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A Physiologically Based Pharmacokinetic Model of Voriconazole Integrating Time-Dependent Inhibition of CYP3A4, Genetic Polymorphisms of CYP2C19 and Predictions of Drug–Drug Interactions

Clinical Pharmacokinetics ◽

10.1007/s40262-019-00856-z ◽

2019 ◽

Vol 59 (6) ◽

pp. 781-808 ◽

Cited By ~ 5

Author(s):

Xia Li ◽

Sebastian Frechen ◽

Daniel Moj ◽

Thorsten Lehr ◽

Max Taubert ◽

...

Keyword(s):

Drug Interactions ◽

Genetic Polymorphisms ◽

Pharmacokinetic Model ◽

Time Dependent ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Dependent Inhibition ◽

Time Dependent Inhibition

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Mechanisms of Herb-Drug Interactions Involving Cinnamon and CYP2A6: Focus on Time-Dependent Inhibition by Cinnamaldehyde and 2-Methoxycinnamaldehyde

Drug Metabolism and Disposition ◽

10.1124/dmd.120.000087 ◽

2020 ◽

Vol 48 (10) ◽

pp. 1028-1043 ◽

Cited By ~ 1

Author(s):

Michael J. Espiritu ◽

Justin Chen ◽

Jaydeep Yadav ◽

Michael Larkin ◽

Robert D. Pelletier ◽

...

Keyword(s):

Drug Interactions ◽

Time Dependent ◽

Dependent Inhibition ◽

Time Dependent Inhibition

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Prediction of reversible and time-dependent inhibition potential of CYP3A4 by Lessertia frutescens fractions and possibility of herb-drug interactions with anti-HIV drugs

Planta Medica ◽

10.1055/s-0034-1382758 ◽

2014 ◽

Vol 80 (10) ◽

Author(s):

C Awortwe ◽

V Manda ◽

S Khan ◽

L Walker ◽

PJ Bouic ◽

...

Keyword(s):

Drug Interactions ◽

Time Dependent ◽

Dependent Inhibition ◽

Hiv Drugs ◽

Time Dependent Inhibition ◽

Anti Hiv

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Refined Prediction of Pharmacokinetic Kratom-Drug Interactions: Time-Dependent Inhibition Considerations

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.120.000270 ◽

2020 ◽

Vol 376 (1) ◽

pp. 64-73

Author(s):

Rakshit S. Tanna ◽

Dan-Dan Tian ◽

Nadja B. Cech ◽

Nicholas H. Oberlies ◽

Allan E. Rettie ◽

...

Keyword(s):

Drug Interactions ◽

Time Dependent ◽

Dependent Inhibition ◽

Time Dependent Inhibition

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In Vitro Screening of Six Protein Kinase Inhibitors for Time-Dependent Inhibition of CYP2C8 and CYP3A4: Possible Implications with regard to Drug-Drug Interactions

Basic & Clinical Pharmacology & Toxicology ◽

10.1111/bcpt.13088 ◽

2018 ◽

Vol 123 (6) ◽

pp. 739-748 ◽

Cited By ~ 6

Author(s):

Anne M. Filppula ◽

Tiffany M. Mustonen ◽

Janne T. Backman

Keyword(s):

Protein Kinase ◽

Drug Interactions ◽

Kinase Inhibitors ◽

Protein Kinase Inhibitors ◽

Time Dependent ◽

In Vitro Screening ◽

Dependent Inhibition ◽

Time Dependent Inhibition

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Prediction of Drug-Drug Interactions based on Time-Dependent Inhibition from High Throughput Screening of Cytochrome P450 3A4 Inhibition

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.24.500 ◽

2009 ◽

Vol 24 (6) ◽

pp. 500-510 ◽

Cited By ~ 24

Author(s):

Nobuo Sekiguchi ◽

Atsuko Higashida ◽

Motohiro Kato ◽

Yoshiaki Nabuchi ◽

Tetsuya Mitsui ◽

...

Keyword(s):

Cytochrome P450 ◽

Drug Interactions ◽

High Throughput ◽

High Throughput Screening ◽

Time Dependent ◽

Cytochrome P450 3A4 ◽

Dependent Inhibition ◽

Time Dependent Inhibition

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Improved Prediction Of Clinical Drug‐Drug Interactions Using A Novel Numerical Method For Evaluation Of Time‐Dependent Inhibition Of Cytochrome P450

The FASEB Journal ◽

10.1096/fasebj.2018.32.1_supplement.834.9 ◽

2018 ◽

Vol 32 (S1) ◽

Author(s):

Jaydeep Yadav ◽

Kenneth Korzekwa ◽

Swati Nagar

Keyword(s):

Cytochrome P450 ◽

Drug Interactions ◽

Numerical Method ◽

Time Dependent ◽

Dependent Inhibition ◽

Time Dependent Inhibition ◽

Clinical Drug

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Improved Predictions of Drug–Drug Interactions Mediated by Time-Dependent Inhibition of CYP3A

Molecular Pharmaceutics ◽

10.1021/acs.molpharmaceut.8b00129 ◽

2018 ◽

Vol 15 (5) ◽

pp. 1979-1995 ◽

Cited By ~ 9

Author(s):

Jaydeep Yadav ◽

Ken Korzekwa ◽

Swati Nagar

Keyword(s):

Drug Interactions ◽

Time Dependent ◽

Dependent Inhibition ◽

Time Dependent Inhibition

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Improved prediction of clinical drug–drug interactions using a novel numerical method for evaluation of time-dependent inhibition of cytochrome P450

Drug Metabolism and Pharmacokinetics ◽

10.1016/j.dmpk.2017.11.082 ◽

2018 ◽

Vol 33 (1) ◽

pp. S19

Author(s):

Jaydeep Yadav ◽

Kenneth Korzekwa ◽

Swati Nagar

Keyword(s):

Cytochrome P450 ◽

Drug Interactions ◽

Numerical Method ◽

Time Dependent ◽

Dependent Inhibition ◽

Time Dependent Inhibition ◽

Clinical Drug

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VX-509 (Decernotinib)-Mediated CYP3A Time-Dependent Inhibition: An Aldehyde Oxidase Metabolite as a Perpetrator of Drug-Drug Interactions

Drug Metabolism and Disposition ◽

10.1124/dmd.116.071100 ◽

2016 ◽

Vol 44 (8) ◽

pp. 1286-1295 ◽

Cited By ~ 19

Author(s):

C. Zetterberg ◽

F. Maltais ◽

L. Laitinen ◽

S. Liao ◽

H. Tsao ◽

...

Keyword(s):

Drug Interactions ◽

Aldehyde Oxidase ◽

Time Dependent ◽

Dependent Inhibition ◽

Time Dependent Inhibition

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