Interplay of Dissolution, Solubility, and Nonsink Permeation Determines the Oral Absorption of the Hedgehog Pathway Inhibitor GDC-0449 in Dogs: An Investigation Using Preclinical Studies and Physiologically Based Pharmacokinetic Modeling

2010 ◽  
Vol 38 (7) ◽  
pp. 1029-1038 ◽  
Author(s):  
Harvey Wong ◽  
Frank-Peter Theil ◽  
Yong Cui ◽  
James C. Marsters ◽  
S. Cyrus Khojasteh ◽  
...  
Keyword(s):  
Oral Absorption ◽  
Pharmacokinetic Modeling ◽  
Hedgehog Pathway ◽  
Preclinical Studies ◽  
Physiologically Based Pharmacokinetic Modeling ◽  
Physiologically Based Pharmacokinetic ◽  
Physiologically Based ◽  
Hedgehog Pathway Inhibitor
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