Systemic Concentrations Can Limit the Oral Absorption of Poorly Soluble Drugs: An Investigation of Non-Sink Permeation Using Physiologically Based Pharmacokinetic Modeling

Po-Chang Chiang; Hank La; Haiming Zhang; Harvey Wong

doi:10.1021/mp400088q

Systemic Concentrations Can Limit the Oral Absorption of Poorly Soluble Drugs: An Investigation of Non-Sink Permeation Using Physiologically Based Pharmacokinetic Modeling

Molecular Pharmaceutics ◽

10.1021/mp400088q ◽

2013 ◽

Vol 10 (11) ◽

pp. 3980-3988 ◽

Cited By ~ 13

Author(s):

Po-Chang Chiang ◽

Hank La ◽

Haiming Zhang ◽

Harvey Wong

Keyword(s):

Oral Absorption ◽

Pharmacokinetic Modeling ◽

Poorly Soluble Drugs ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Poorly Soluble

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Evaluating the Role of Solubility in Oral Absorption of Poorly Water‐Soluble Drugs Using Physiologically‐Based Pharmacokinetic Modeling

Clinical Pharmacology & Therapeutics ◽

10.1002/cpt.1672 ◽

2019 ◽

Vol 107 (3) ◽

pp. 650-661 ◽

Cited By ~ 1

Author(s):

Christina Fink ◽

Dajun Sun ◽

Knut Wagner ◽

Melanie Schneider ◽

Holger Bauer ◽

...

Keyword(s):

Oral Absorption ◽

Pharmacokinetic Modeling ◽

Water Soluble ◽

Physiologically Based Pharmacokinetic Modeling ◽

Poorly Water Soluble Drugs ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Water Soluble Drugs ◽

Poorly Water Soluble

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Physiologically Based Pharmacokinetic Modeling of Oral Absorption, pH, and Food Effect in Healthy Volunteers to Drive Alpelisib Formulation Selection

The AAPS Journal ◽

10.1208/s12248-020-00511-7 ◽

2020 ◽

Vol 22 (6) ◽

Author(s):

Monika Gajewska ◽

Lars Blumenstein ◽

Alexandros Kourentas ◽

Martin Mueller-Zsigmondy ◽

Sebastien Lorenzo ◽

...

Keyword(s):

Healthy Volunteers ◽

Oral Absorption ◽

Food Effect ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Interplay of Dissolution, Solubility, and Nonsink Permeation Determines the Oral Absorption of the Hedgehog Pathway Inhibitor GDC-0449 in Dogs: An Investigation Using Preclinical Studies and Physiologically Based Pharmacokinetic Modeling

Drug Metabolism and Disposition ◽

10.1124/dmd.110.032680 ◽

2010 ◽

Vol 38 (7) ◽

pp. 1029-1038 ◽

Cited By ~ 15

Author(s):

Harvey Wong ◽

Frank-Peter Theil ◽

Yong Cui ◽

James C. Marsters ◽

S. Cyrus Khojasteh ◽

...

Keyword(s):

Oral Absorption ◽

Pharmacokinetic Modeling ◽

Hedgehog Pathway ◽

Preclinical Studies ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Hedgehog Pathway Inhibitor

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Physiologically-based pharmacokinetic modeling of different size polyethylene glycol-coated gold nanoparticles in mice

10.1615/ihtc16.nmt.023362 ◽

2018 ◽

Author(s):

Linjing Deng ◽

Jinping Zhao ◽

Yufeng Miao ◽

Xu Hu ◽

Qihong Deng

Keyword(s):

Gold Nanoparticles ◽

Polyethylene Glycol ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Physiologically-Based Pharmacokinetic Modeling to Predict Changes in Drug Exposure during Pregnancy Using the Simcyp Simulator

10.26226/morressier.57d6b2b7d462b8028d88e945 ◽

2016 ◽

Author(s):

Suvarchala Kiranmai Avvari

Keyword(s):

Drug Exposure ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Exposure During Pregnancy

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Physiologically‐Based Pharmacokinetic Modeling of Atorvastatin Incorporating Delayed Gastric Emptying and Acid‐to‐Lactone Conversion

CPT Pharmacometrics & Systems Pharmacology ◽

10.1002/psp4.12447 ◽

2019 ◽

Vol 8 (9) ◽

pp. 664-675 ◽

Cited By ~ 5

Author(s):

Bridget L. Morse ◽

Jeffrey J. Alberts ◽

Maria M. Posada ◽

Jessica Rehmel ◽

Anil Kolur ◽

...

Keyword(s):

Gastric Emptying ◽

Delayed Gastric Emptying ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Preliminary physiologically based pharmacokinetic modeling of renally cleared drugs in Chinese pregnant women

Biopharmaceutics & Drug Disposition ◽

10.1002/bdd.2243 ◽

2020 ◽

Vol 41 (6) ◽

pp. 248-267 ◽

Cited By ~ 1

Author(s):

Ling Song ◽

Zhiheng Yu ◽

Yifan Xu ◽

Xiaobei Li ◽

Xuanlin Liu ◽

...

Keyword(s):

Pregnant Women ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Prediction of fluoxetine and norfluoxetine pharmacokinetic profiles using physiologically based pharmacokinetic modeling

The Journal of Clinical Pharmacology ◽

10.1002/jcph.1927 ◽

2021 ◽

Author(s):

Hyeon‐Cheol Jeong ◽

Yoon‐Jee Chae ◽

Sooyeun Lee ◽

Wonku Kang ◽

Hwi‐yeol Yun ◽

...

Keyword(s):

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Pharmacokinetic Profiles ◽

Physiologically Based

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Physiologically Based Pharmacokinetic Modeling Approach to Predict Drug‐Drug Interactions With Ethionamide Involving Impact of Genetic Polymorphism on FMO3

The Journal of Clinical Pharmacology ◽

10.1002/jcph.1378 ◽

2019 ◽

Vol 59 (6) ◽

pp. 880-889 ◽

Cited By ~ 1

Author(s):

Phuong Thi Thu Nguyen ◽

Md Masud Parvez ◽

Min Jung Kim ◽

Sung Eun Yoo ◽

Sangzin Ahn ◽

...

Keyword(s):

Genetic Polymorphism ◽

Drug Interactions ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Modeling Approach ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Physiologically Based Pharmacokinetic Modeling and Tissue Distribution Characteristics of SHetA2 in Tumor-Bearing Mice

The AAPS Journal ◽

10.1208/s12248-020-0421-z ◽

2020 ◽

Vol 22 (2) ◽

Author(s):

Ankur Sharma ◽

Mengjie Li ◽

Elangovan Thavathiru ◽

Mariam Ibrahim ◽

Lucila Garcia-Contreras ◽

...

Keyword(s):

Tissue Distribution ◽

Pharmacokinetic Modeling ◽

Distribution Characteristics ◽

Physiologically Based Pharmacokinetic Modeling ◽

Tumor Bearing ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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