An Unexpected Synergist Role of P-Glycoprotein and Breast Cancer Resistance Protein on the Central Nervous System Penetration of the Tyrosine Kinase Inhibitor Lapatinib (N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine; GW572016): TABLE 1

Joseph W. Polli; Katie L. Olson; John P. Chism; Lisa St. John-Williams; Russell L. Yeager; Sesha M. Woodard; Vicky Otto; Stephen Castellino; Victoria E. Demby

doi:10.1124/dmd.108.024646

An Unexpected Synergist Role of P-Glycoprotein and Breast Cancer Resistance Protein on the Central Nervous System Penetration of the Tyrosine Kinase Inhibitor Lapatinib (N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine; GW572016): TABLE 1

Drug Metabolism and Disposition ◽

10.1124/dmd.108.024646 ◽

2008 ◽

Vol 37 (2) ◽

pp. 439-442 ◽

Cited By ~ 174

Author(s):

Joseph W. Polli ◽

Katie L. Olson ◽

John P. Chism ◽

Lisa St. John-Williams ◽

Russell L. Yeager ◽

...

Keyword(s):

Breast Cancer ◽

Central Nervous System ◽

Breast Cancer Resistance Protein ◽

Kinase Inhibitor ◽

Cancer Resistance ◽

P Glycoprotein ◽

Central Nervous System Penetration ◽

The Central Nervous System ◽

Resistance Protein

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Saturable Active Efflux by P-Glycoprotein and Breast Cancer Resistance Protein at the Blood-Brain Barrier Leads to Nonlinear Distribution of Elacridar to the Central Nervous System

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.112.199786 ◽

2013 ◽

Vol 345 (1) ◽

pp. 111-124 ◽

Cited By ~ 26

Author(s):

Ramola Sane ◽

Sagar Agarwal ◽

Rajendar K. Mittapalli ◽

William F. Elmquist

Keyword(s):

Breast Cancer ◽

Central Nervous System ◽

Nervous System ◽

Breast Cancer Resistance Protein ◽

Cancer Resistance ◽

Active Efflux ◽

P Glycoprotein ◽

The Central Nervous System ◽

Resistance Protein ◽

Nonlinear Distribution

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Investigation of the Role of Breast Cancer Resistance Protein (Bcrp/Abcg2) on Pharmacokinetics and Central Nervous System Penetration of Abacavir and Zidovudine in the Mouse

Drug Metabolism and Disposition ◽

10.1124/dmd.108.020974 ◽

2008 ◽

Vol 36 (8) ◽

pp. 1476-1484 ◽

Cited By ~ 49

Author(s):

Nagdeep Giri ◽

Naveed Shaik ◽

Guoyu Pan ◽

Tetsuya Terasaki ◽

Chisato Mukai ◽

...

Keyword(s):

Breast Cancer ◽

Central Nervous System ◽

Nervous System ◽

Breast Cancer Resistance Protein ◽

Cancer Resistance ◽

Central Nervous System Penetration ◽

Resistance Protein

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The Pim kinase inhibitor SGI-1776 decreases cell surface expression of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and drug transport by Pim-1-dependent and -independent mechanisms

Biochemical Pharmacology ◽

10.1016/j.bcp.2012.12.006 ◽

2013 ◽

Vol 85 (4) ◽

pp. 514-524 ◽

Cited By ~ 54

Author(s):

Karthika Natarajan ◽

Jasjeet Bhullar ◽

Suneet Shukla ◽

Mehmet Burcu ◽

Zhe-Sheng Chen ◽

...

Keyword(s):

Breast Cancer ◽

Cell Surface ◽

Drug Transport ◽

Breast Cancer Resistance Protein ◽

Kinase Inhibitor ◽

Surface Expression ◽

Cell Surface Expression ◽

Cancer Resistance ◽

P Glycoprotein ◽

Resistance Protein

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ATP-binding cassette transporters in primary central nervous system lymphoma: Decreased expression of MDR1 P-glycoprotein and breast cancer resistance protein in tumor capillary endothelial cells

Oncology Reports ◽

10.3892/or.2010.1102 ◽

2011 ◽

Vol 25 (2) ◽

Author(s):

Fujiwara

Keyword(s):

Breast Cancer ◽

Central Nervous System ◽

Nervous System ◽

Breast Cancer Resistance Protein ◽

Central Nervous System Lymphoma ◽

Cancer Resistance ◽

P Glycoprotein ◽

Atp Binding Cassette Transporters ◽

Capillary Endothelial Cells ◽

Resistance Protein

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P-Glycoprotein and Breast Cancer Resistance Protein Affect Disposition of Tandutinib, A Tyrosine Kinase Inhibitor

Drug Metabolism Letters ◽

10.2174/187231210792928279 ◽

2010 ◽

Vol 4 (4) ◽

pp. 202-212 ◽

Cited By ~ 31

Author(s):

Johnny J. Yang ◽

Mark N. Milton ◽

Shaoxia Yu ◽

Mingxiang Liao ◽

Ning Liu ◽

...

Keyword(s):

Breast Cancer ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitor ◽

Breast Cancer Resistance Protein ◽

Kinase Inhibitor ◽

Cancer Resistance ◽

P Glycoprotein ◽

Resistance Protein

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Differential role of P-glycoprotein and breast cancer resistance protein in drug distribution into brain, CSF and peripheral nerve tissues in rats

Xenobiotica ◽

10.3109/00498254.2014.997324 ◽

2014 ◽

Vol 45 (6) ◽

pp. 547-555 ◽

Cited By ~ 13

Author(s):

Liyue Huang ◽

Xingwen Li ◽

Jonathan Roberts ◽

Brett Janosky ◽

Min-Hwa Jasmine Lin

Keyword(s):

Breast Cancer ◽

Peripheral Nerve ◽

Breast Cancer Resistance Protein ◽

Drug Distribution ◽

Cancer Resistance ◽

P Glycoprotein ◽

Resistance Protein

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The role of P-glycoprotein and breast cancer resistance protein (BCRP) in bacterial attachment to human gastrointestinal cells

Journal of Crohn s and Colitis ◽

10.1016/j.crohns.2011.05.002 ◽

2011 ◽

Vol 5 (6) ◽

pp. 531-542 ◽

Cited By ~ 10

Author(s):

Andrew Crowe

Keyword(s):

Breast Cancer ◽

Breast Cancer Resistance Protein ◽

Bacterial Attachment ◽

Cancer Resistance ◽

P Glycoprotein ◽

Resistance Protein

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In Vitro Comparison of the Role of P-Glycoprotein and Breast Cancer Resistance Protein on Direct Oral Anticoagulants Disposition

European Journal of Drug Metabolism and Pharmacokinetics ◽

10.1007/s13318-017-0434-x ◽

2017 ◽

Vol 43 (2) ◽

pp. 183-191 ◽

Cited By ~ 21

Author(s):

Sophie Hodin ◽

Thierry Basset ◽

Elodie Jacqueroux ◽

Olivier Delezay ◽

Anthony Clotagatide ◽

...

Keyword(s):

Breast Cancer ◽

Breast Cancer Resistance Protein ◽

Oral Anticoagulants ◽

Direct Oral Anticoagulants ◽

Cancer Resistance ◽

P Glycoprotein ◽

Resistance Protein ◽

In Vitro Comparison

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P-glycoprotein and breast cancer resistance protein in acute myeloid leukaemia cells treated with the Aurora-B Kinase Inhibitor barasertib-hQPA

BMC Cancer ◽

10.1186/1471-2407-11-254 ◽

2011 ◽

Vol 11 (1) ◽

Cited By ~ 12

Author(s):

Martin Grundy ◽

Claire Seedhouse ◽

Nigel H Russell ◽

Monica Pallis

Keyword(s):

Breast Cancer ◽

Acute Myeloid Leukaemia ◽

Myeloid Leukaemia ◽

Breast Cancer Resistance Protein ◽

Kinase Inhibitor ◽

Aurora B ◽

Cancer Resistance ◽

P Glycoprotein ◽

Resistance Protein ◽

Acute Myeloid

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Role of P-Glycoprotein and Breast Cancer Resistance Protein-1 in the Brain Penetration and Brain Pharmacodynamic Activity of the Novel Phosphatidylinositol 3-Kinase Inhibitor GDC-0941

Drug Metabolism and Disposition ◽

10.1124/dmd.110.034256 ◽

2010 ◽

Vol 38 (9) ◽

pp. 1422-1426 ◽

Cited By ~ 21

Author(s):

Laurent Salphati ◽

Leslie B. Lee ◽

Jodie Pang ◽

Emile G. Plise ◽

Xiaolin Zhang

Keyword(s):

Breast Cancer Resistance Protein ◽

Kinase Inhibitor ◽

The Novel ◽

Cancer Resistance ◽

Phosphatidylinositol 3 Kinase ◽

Brain Penetration ◽

P Glycoprotein ◽

Resistance Protein ◽

The Brain

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