Investigation of the Role of Breast Cancer Resistance Protein (Bcrp/Abcg2) on Pharmacokinetics and Central Nervous System Penetration of Abacavir and Zidovudine in the Mouse

Nagdeep Giri; Naveed Shaik; Guoyu Pan; Tetsuya Terasaki; Chisato Mukai; Shinji Kitagaki; Naoki Miyakoshi; William F. Elmquist

doi:10.1124/dmd.108.020974

Investigation of the Role of Breast Cancer Resistance Protein (Bcrp/Abcg2) on Pharmacokinetics and Central Nervous System Penetration of Abacavir and Zidovudine in the Mouse

Drug Metabolism and Disposition ◽

10.1124/dmd.108.020974 ◽

2008 ◽

Vol 36 (8) ◽

pp. 1476-1484 ◽

Cited By ~ 49

Author(s):

Nagdeep Giri ◽

Naveed Shaik ◽

Guoyu Pan ◽

Tetsuya Terasaki ◽

Chisato Mukai ◽

...

Keyword(s):

Breast Cancer ◽

Central Nervous System ◽

Nervous System ◽

Breast Cancer Resistance Protein ◽

Cancer Resistance ◽

Central Nervous System Penetration ◽

Resistance Protein

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An Unexpected Synergist Role of P-Glycoprotein and Breast Cancer Resistance Protein on the Central Nervous System Penetration of the Tyrosine Kinase Inhibitor Lapatinib (N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine; GW572016): TABLE 1

Drug Metabolism and Disposition ◽

10.1124/dmd.108.024646 ◽

2008 ◽

Vol 37 (2) ◽

pp. 439-442 ◽

Cited By ~ 174

Author(s):

Joseph W. Polli ◽

Katie L. Olson ◽

John P. Chism ◽

Lisa St. John-Williams ◽

Russell L. Yeager ◽

...

Keyword(s):

Breast Cancer ◽

Central Nervous System ◽

Breast Cancer Resistance Protein ◽

Kinase Inhibitor ◽

Cancer Resistance ◽

P Glycoprotein ◽

Central Nervous System Penetration ◽

The Central Nervous System ◽

Resistance Protein

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ATP-binding cassette transporters in primary central nervous system lymphoma: Decreased expression of MDR1 P-glycoprotein and breast cancer resistance protein in tumor capillary endothelial cells

Oncology Reports ◽

10.3892/or.2010.1102 ◽

2011 ◽

Vol 25 (2) ◽

Author(s):

Fujiwara

Keyword(s):

Breast Cancer ◽

Central Nervous System ◽

Nervous System ◽

Breast Cancer Resistance Protein ◽

Central Nervous System Lymphoma ◽

Cancer Resistance ◽

P Glycoprotein ◽

Atp Binding Cassette Transporters ◽

Capillary Endothelial Cells ◽

Resistance Protein

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Saturable Active Efflux by P-Glycoprotein and Breast Cancer Resistance Protein at the Blood-Brain Barrier Leads to Nonlinear Distribution of Elacridar to the Central Nervous System

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.112.199786 ◽

2013 ◽

Vol 345 (1) ◽

pp. 111-124 ◽

Cited By ~ 26

Author(s):

Ramola Sane ◽

Sagar Agarwal ◽

Rajendar K. Mittapalli ◽

William F. Elmquist

Keyword(s):

Breast Cancer ◽

Central Nervous System ◽

Nervous System ◽

Breast Cancer Resistance Protein ◽

Cancer Resistance ◽

Active Efflux ◽

P Glycoprotein ◽

The Central Nervous System ◽

Resistance Protein ◽

Nonlinear Distribution

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Absence of both MDR1 (ABCB1) and Breast Cancer Resistance Protein (ABCG2) Transporters Significantly Alters Rivaroxaban Disposition and Central Nervous System Entry

Basic & Clinical Pharmacology & Toxicology ◽

10.1111/bcpt.12005 ◽

2012 ◽

Vol 112 (3) ◽

pp. 164-170 ◽

Cited By ~ 24

Author(s):

Inna Y. Gong ◽

Sara E. Mansell ◽

Richard B. Kim

Keyword(s):

Breast Cancer ◽

Central Nervous System ◽

Nervous System ◽

Breast Cancer Resistance Protein ◽

Cancer Resistance ◽

Resistance Protein

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Role of Cys-603 in dimer/oligomer formation of the breast cancer resistance protein BCRP/ABCG2

Cancer Science ◽

10.1111/j.1349-7006.2005.00126.x ◽

2005 ◽

Vol 96 (12) ◽

pp. 866-872 ◽

Cited By ~ 57

Author(s):

Kumie Kage ◽

Toshiro Fujita ◽

Yoshikazu Sugimoto

Keyword(s):

Breast Cancer ◽

Breast Cancer Resistance Protein ◽

Cancer Resistance ◽

Oligomer Formation ◽

Resistance Protein

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Role of breast cancer resistance protein (BCRP/ABCG2) in cancer drug resistance

Biochemical Pharmacology ◽

10.1016/j.bcp.2012.01.002 ◽

2012 ◽

Vol 83 (8) ◽

pp. 1084-1103 ◽

Cited By ~ 229

Author(s):

Karthika Natarajan ◽

Yi Xie ◽

Maria R. Baer ◽

Douglas D. Ross

Keyword(s):

Breast Cancer ◽

Drug Resistance ◽

Breast Cancer Resistance Protein ◽

Cancer Drug ◽

Cancer Resistance ◽

Cancer Drug Resistance ◽

Resistance Protein

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Role of breast cancer resistance protein (BCRP) as active efflux transporter on blood-brain barrier (BBB) permeability

Molecular Diversity ◽

10.1007/s11030-014-9562-2 ◽

2014 ◽

Vol 19 (1) ◽

pp. 163-172 ◽

Cited By ~ 18

Author(s):

Prabha Garg ◽

Rahul Dhakne ◽

Vilas Belekar

Keyword(s):

Breast Cancer ◽

Blood Brain Barrier ◽

Breast Cancer Resistance Protein ◽

Brain Barrier ◽

Efflux Transporter ◽

Cancer Resistance ◽

Active Efflux ◽

Blood Brain ◽

Resistance Protein

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Role of the Breast Cancer Resistance Protein (BCRP/ABCG2) in Drug Transport—an Update

The AAPS Journal ◽

10.1208/s12248-014-9668-6 ◽

2014 ◽

Vol 17 (1) ◽

pp. 65-82 ◽

Cited By ~ 238

Author(s):

Qingcheng Mao ◽

Jashvant D. Unadkat

Keyword(s):

Breast Cancer ◽

Drug Transport ◽

Breast Cancer Resistance Protein ◽

Cancer Resistance ◽

Resistance Protein

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Chemical inhibition and stable knock-down of efflux transporters leads to reduced glucuronidation of wushanicaritin in UGT1A1-overexpressing HeLa cells: the role of breast cancer resistance protein (BCRP) and multidrug resistance-associated proteins (MRPs) in the excretion of glucuronides

Food & Function ◽

10.1039/c7fo01298e ◽

2018 ◽

Vol 9 (3) ◽

pp. 1410-1423 ◽

Cited By ~ 13

Author(s):

Zifei Qin ◽

Shishi Li ◽

Zhihong Yao ◽

Xiaodan Hong ◽

Baojian Wu ◽

...

Keyword(s):

Breast Cancer ◽

Multidrug Resistance ◽

Hela Cells ◽

Breast Cancer Resistance Protein ◽

Efflux Transporters ◽

Cancer Resistance ◽

Associated Proteins ◽

Resistance Protein ◽

Chemical Inhibition

We determine the contributions of BCRP and MRP transporters in HeLa cells.

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Kinetic modelling of the role of the aldehyde dehydrogenase enzyme and the breast cancer resistance protein in drug resistance and transport

IFAC Proceedings Volumes ◽

10.3182/20090812-3-dk-2006.0093 ◽

2009 ◽

Vol 42 (12) ◽

pp. 109-114

Author(s):

Mohammed I. Atari ◽

Michael J. Chappell ◽

Rachel J. Errington ◽

Paul J. Smith ◽

Neil D. Evans

Keyword(s):

Breast Cancer ◽

Drug Resistance ◽

Aldehyde Dehydrogenase ◽

Breast Cancer Resistance Protein ◽

Kinetic Modelling ◽

Cancer Resistance ◽

Dehydrogenase Enzyme ◽

Resistance Protein

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