Regulation of Drug Transporter Expression in Human Hepatocytes Exposed to the Proinflammatory Cytokines Tumor Necrosis Factor-α or Interleukin-6

2008 ◽  
Vol 37 (3) ◽  
pp. 685-693 ◽  
Author(s):  
Marc Le Vee ◽  
Valérie Lecureur ◽  
Bruno Stieger ◽  
Olivier Fardel
Keyword(s):  
Tumor Necrosis Factor ◽  
Proinflammatory Cytokines ◽  
Interleukin 6 ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Human Hepatocytes ◽  
Drug Transporter ◽  
Factor Α ◽  
Transporter Expression ◽  
Necrosis Factor

scholarly journals FRI0374 PLASMA LEVELS OF 14-3-3 PROTEIN, S100A8/S100A9-PROTEIN, INTERLEUKIN-6, INTERLEUKIN-18, INTERLEUKIN-4, INTERLEUKIN-17, INTERLEUKIN-1Β AND TUMOR NECROSIS FACTOR-Α IN CHRONIC NON-BACTERIAL OSTEOMYEILITIS AND NON-SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 784.3-784
Author(s):  
M. Kostik ◽  
M. Makhova ◽  
D. Kozlova ◽  
D. Vasilyev ◽  
L. Sorokina ◽  
...  
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Tumor Necrosis Factor ◽  
Interleukin 6 ◽  
Plasma Levels ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Systemic Juvenile Idiopathic Arthritis ◽  
Immune Mediated ◽  
Factor Α ◽  
Necrosis Factor

Background:Chronic non-bacterial osteomyelitis (CNO) is an immune-mediated disease associated with cytokine dysbalance.Objectives:The aim of our study was to evaluate the cytokines levels in CNO and compare to juvenile idiopathic arthritis (JIA) – disease with immune-mediated mechanism.Methods:The diagnosis of CNO made with criteria, proposed by Jansson (2007, 2009), after the exclusion of other causes of bone disease [1]. We included 42 patients with NBO, 28 patients with non-systemic juvenile idiopathic arthritis (JIA). We evaluated plasma levels of 14-3-3 protein, S100A8/S100A9-protein, interleukine-6 (IL-6), interleukine-18 (IL-18), interleukine-4 (IL-4), interleukine-17 (IL-17), interleukine-1β (IL-1 β) and tumor necrosis factor-α (TNFα) in 2 groups by the ELISA. Statistical analysis was carried out with Statistica 10.0 software. We utilized descriptive statistics (Me; IQR), Mann-Whitney tests.Results:We have found differences in the proinflammatory biomarkers between CNO, JIA. Patients with NBO had lower levels of studied cytokines, exclude14-3-3-protein, S100A8/S100A9 and interleukin-6 compare to JIA patients (table 1).Table 1.Comparison the cytokine levels between CNO, JIA NParameterNBO (n=42)JIA (n=28)pHemoglobin, g/l112 (104; 124)120 (114.5; 126.0)0.02WBC x 109/l7.9 (7.0; 10.5)8.0 (6.7; 10.0)0.86PLT x 109/l347 (259; 408)336.5 (274.0; 390.5)0.98ESR. mm/h25.0 (9.0; 46.0)8.5 (2.5; 13.0)0.013CRP, mg/l6.1 (0.6; 2.4)1.8 (0.4; 11.9)0.02714-3-3, ng/ml21.4 (18.5; 27.1)19.9 (18.0; 27.8)0.77S100A8/S100A9, ng/ml5.9 (5.2; 6.5)5.9 (5.0; 6.2)0.76IL-6, ng/ml126,2 (112.8; 137.5)132.4 (117.4; 142.9)0.16IL-18, ng/ml270.1 (200.1; 316.1)388.3 (373.9; 405.1)0.0000001IL-4, ng/ml15.3 (11.5; 18.2)18.7 (16.2; 20.2)0.003IL-17, ng/ml83.1 (71.1; 97.3)99.2 (87.3; 115.8)0.003IL-1b, ng/ml47.4 (42.0; 51.3)70.8 (65.3; 73.6)0.0000001TNFa, ng/ml19.4 (17.8; 21.3)23.1 (20.2; 25.9)0.0006Conclusion:Patients with CNO had less proinflammatory activity then JIA patients, besides IL-6 and S100A8/S100A9. Further investigations required for finding new more precise biomarkers and finding possible molecular targets for treatment.This work supported by the Russian Foundation for Basic Research (grant № 18-515-57001)References:[1]Jansson AF, et al. Clinical score for nonbacterial osteitis in children and adults. Arthritis Rheum. 2009;60(4):1152-9.Disclosure of Interests:None declared

Tumor necrosis factor α and interleukin 6 plasma levels in infected cirrhotic patients

1993 ◽  
Vol 104 (5) ◽  
pp. 1492-1497 ◽  
Author(s):  
Baudouin Byl ◽  
Ingrid Roucloux ◽  
Alain Crusiaux ◽  
Etienne Dupont ◽  
Jaqugs Devière
Keyword(s):  
Tumor Necrosis Factor ◽  
Interleukin 6 ◽  
Plasma Levels ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Cirrhotic Patients ◽  
Factor Α ◽  
Necrosis Factor

Maternal serum interleukin-6, interleukin-8, tumor necrosis factor-α and interferon-γ in preterm labor

2003 ◽  
Vol 82 (6) ◽  
pp. 543-549
Author(s):  
Ahmed M. Bahar ◽  
Hashim W. Ghalib ◽  
Riyad A. Moosa ◽  
Zaki M. S. Zaki ◽  
Chet Thomas ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Interleukin 6 ◽  
Preterm Labor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Interferon Γ ◽  
Maternal Serum ◽  
Interleukin 8 ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Salivary levels of interleukin-6 and tumor necrosis factor-α in patients undergoing hemodialysis

2016 ◽  
Vol 13 (1) ◽  
pp. 69 ◽  
Author(s):  
Milad Alikhani ◽  
Faezeh Khozeymeh ◽  
Mojgan Mortazavi ◽  
Navid Khalighinejad ◽  
Mehrdad Akhavankhaleghi
Keyword(s):  
Tumor Necrosis Factor ◽  
Interleukin 6 ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Cytokine and Antimicrobial Peptide Levels in Cholelithiasis

2021 ◽  
Vol 88 (1-2) ◽  
pp. 23-27
Author(s):  
K. F. Gasimova
Keyword(s):  
Tumor Necrosis Factor ◽  
Antimicrobial Peptides ◽  
Interleukin 6 ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Standard Treatment ◽  
Postoperative Treatment ◽  
Enzyme Preparations ◽  
Factor Α ◽  
Necrosis Factor

Objective. To study the cytokines and antimicrobial peptides concentrations in patients with cholelitiasis during 1 year treatment before and after the surgery. Materials and methods. 38 patients with a cholelithiasis were examined and operated in the Educational-Surgical Clinic of the Azerbaijan Medical University. According to the treatment regimen after the operation the patients were divided into two groups: patients of the 1st group (n = 17) received standard treatment; patients of 2nd group (n = 21), in addition to standard treatment hepatoprotectors, combined enzyme preparations, pre- and probiotics were prescribed. The control group consisted of 14 apparently healthy individuals. The levels of inflammatory cytokines (interleukin-6 and tumor necrosis factor-α) in the blood and antimicrobial peptides (zonulin, calprotectin, and lactoferrin) in feces we studied with enzyme immunoassay method. Results. In patients with cholelithiasis of the 1st group, the concentration of interleukin-6 was significantly increased by 5 times (p <0.001), the concentration of tumor necrosis factor-α - by 3.5 times (p <0.001), of zonulin - by 2.2 times (p = 0.012), of calprotectin - by 5.8 times (p <0.001, the concentration of lactoferrin - by 60 times (p <0.001), and in the 2nd group - by 4.8 times (p <0.001), by 3.1 times (p <0.001), on 91.7% (p = 0.011), by 5.8 times (p <0.001) and by 52.8 times (p <0.001) respectively in comparison with the control. Conclusions. Standard postoperative treatment supplemented by hepatoprotectors, combined enzyme preparations, pre- and probiotics prescription leads to a positive dynamics of inflammatory mediators concentration and its normalization.

Postprandial response of adiponectin, interleukin-6, tumor necrosis factor-α, and C-reactive protein to a high-fat dietary load

Nutrition ◽  
2008 ◽  
Vol 24 (4) ◽  
pp. 322-329 ◽  
Author(s):  
Sally D. Poppitt ◽  
Geraldine F. Keogh ◽  
Fiona E. Lithander ◽  
Yu Wang ◽  
Tom B. Mulvey ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Interleukin 6 ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
C Reactive Protein ◽  
High Fat ◽  
Reactive Protein ◽  
Postprandial Response ◽  
Factor Α ◽  
Necrosis Factor
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