Debunking unusual false noise damage claims

2019 ◽  
Vol 146 (4) ◽  
pp. 2874-2874
Author(s):  
Marlund E. Hale
Keyword(s):  
Damage Claims ◽  
Noise Damage

Debunking unusual false noise damage claims

2018 ◽  
Vol 144 (3) ◽  
pp. 1929-1929
Author(s):  
Marlund E. Hale
Keyword(s):  
Damage Claims ◽  
Noise Damage

Magnesium and Hearing

2003 ◽  
Vol 14 (04) ◽  
pp. 202-212 ◽  
Author(s):  
Michael J. Cevette ◽  
Jürgen Vormann ◽  
Kay Franz
Keyword(s):  
Hair Cells ◽  
Auditory Nerve ◽  
Mg Deficiency ◽  
Noise Damage ◽  
Susceptibility To Noise ◽  
Major Progress ◽  
A Current ◽  
Putative Mechanism ◽  
Increased Susceptibility

The last several decades have revealed clinical and experimental data regarding the importance of magnesium (Mg) in hearing. Increased susceptibility to noise damage, ototoxicity, and auditory hyperexcitibility are linked to states of Mg deficiency. Evidence for these processes has come slowly and direct effects have remained elusive because plasma Mg levels do not always correlate with its deficiency. Despite the major progress in the understanding of cochlear mechanical and auditory nerve function, the neurochemical and pharmacologic role of Mg is not clear. The putative mechanism suggests that Mg deficiency may contribute to a metabolic cellular cascade of events. Mg deficiency leads to an increased permeability of the calcium channel in the hair cells with a consequent over influx of calcium, an increased release of glutamate via exocytosis, and over stimulation of NMDA receptors on the auditory nerve. This paper provides a current overview of relevant Mg metabolism and deficiency and its influence on hearing.

Die Nacherfüllung aus Verkäufersicht

2022 ◽  
Author(s):  
Constantin Jungclaus
Keyword(s):  
Case Law ◽  
European Court Of Justice ◽  
Focal Points ◽  
European Union Law ◽  
Economic Interests ◽  
Court Of Justice ◽  
European Court ◽  
Specific Performance ◽  
Damage Claims ◽  
High Level

The thesis examines the question of which of the compared sales law systems is most likely to realize the (economic) interests of the seller in connection with the consumer’s claim for specific performance, which is characterized by a high level of consumer protection. In this respect, the thesis examines 7 different complexes - from the position of specific performance in the system of purchase warranty rights to the scope of specific performance owed and the objection of disproportionality. Dogmatic focal points are, for example, the problem of self-execution in the light of European Union law and the allocation of certain damage items to specific performance or to damage claims in the light of the case law of the European Court of Justice.

scholarly journals Partial Hearing Restoration after ERBB2 Induction in Deafened Adult Mice

2019 ◽  
Author(s):  
Jingyuan Zhang ◽  
Daxiang Na ◽  
Miriam Dilts ◽  
Kenneth S. Henry ◽  
Patricia M. White
Keyword(s):  
Cell Proliferation ◽  
Hearing Loss ◽  
Noise Exposure ◽  
Supporting Cell ◽  
Supporting Cells ◽  
Adult Mice ◽  
Hearing Thresholds ◽  
Brainstem Response ◽  
Noise Damage ◽  
Cochlear Supporting Cells

AbstractNoise induced hearing loss (NIHL) affects over ten million adults in the United States, and there is no biological treatment to restore endogenous function after damage. We hypothesized that activation of signaling from ERBB2 receptors in cochlear supporting cells could mitigate NIHL damage. We used the Tet-On genetic expression system to drive a constitutively active variant of ERBB2 (CA-ERBB2) in cochlear supporting cells three days after permanent noise damage in young adult mice. Hearing thresholds were assessed with auditory brainstem response tests prior to noise damage, and hearing recovery was assessed over a three month period. We evaluated supporting cell proliferation, inner and outer hair cell (IHC and OHC) survival, synaptic preservation, and IHC cytoskeletal alterations with histological techniques. Mice harboring CA-ERBB2 capability had similar hearing thresholds to control littermates prior to and immediately after noise exposure, and incurred similar levels of permanent hearing loss. Two and three months after noise exposure, CA-ERBB2+ mice demonstrated a partial but significant reversal of NIHL threshold shifts at the lowest frequency tested, out of five frequencies (n=19 total mice, p=0.0015, ANOVA). We also observed improved IHC and OHC survival (n=7 total cochleae, p=5 × 10−5, Kruskal-Wallis rank sum test). There was no evidence for sustained supporting cell proliferation. Some mortality was associated with doxycycline and furosemide treatments to induce the Tet-ON system. These data suggest that ERBB2 signaling in supporting cells promotes HC repair and some functional recovery. Funded by NIH R01 DC014261, and grants from the Schmitt Foundation and UR Ventures.

scholarly journals Analysis of Low Speed Vehicle Impact Damage

1991 ◽  
Vol 8 (1) ◽  
Author(s):  
Lester R. Reekers
Keyword(s):  
Impact Damage ◽  
Recent Decade ◽  
Legal Issues ◽  
Average Annual Rate ◽  
Low Velocity ◽  
Bodily Injury ◽  
Vehicle Impact ◽  
Damage Claims ◽  
Forensic Engineering ◽  
Car Insurance

Disputes resulting from low-velocity vehicular collisions have increased dramatically in number during the recent decade. According to the California State Insurance Department, staged auto accidents have risen at an average annual rate of 38% since 1986. Hard figures are not available, but most experts say 10% to 15% of all claim dollars paid out on car insurance result from some form of fakery. According to the Insurance Information Institute, that works out to between $5.4 billion and $8.1 billion of the $54 billion in claims paid last year. An Insurance Research Council study shows that in 1989 insurers paid 55.7 injury claims in California for every 100 auto property damage claims, and 57% of those making bodily injury claims were represented by an attorney. Litigators frequently utilize the assistance of the forensic engineering expert to resolve the legal issues involved in these disputes. Available reference materials for the analysis may be minimal, consisting only of c

Experimental Study of the Effects of Jet Noise on an Aircraft Structure

1957 ◽  
Vol 61 (554) ◽  
pp. 112-114
Author(s):  
K. W. Hetzel
Keyword(s):  
Experimental Study ◽  
Jet Noise ◽  
Aircraft Structure ◽  
Noise Effects ◽  
Noise Damage

Reports of noise effects on the rear fuselage structure of large British aircraft indicated that one might expect noise damage in this region on the Vickers Supermarine Type 544 aircraft. It will be seen from Fig. 1 that the jet efflux from each engine passes close to the fuselage side and under the tailplane. The fuselage structure proper is, however, protected from the heat and noise effects at the jet efflux by a fairing which is insulated at all attachments. This fairing, by virtue of its shape, is called the “ pen nib. ”

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