Hot Topics—Hidden hearing loss: Permanent cochlear-nerve degeneration after temporary noise-induced threshold shift

2014 ◽  
Vol 135 (4) ◽  
pp. 2311-2311 ◽  
Author(s):  
M. Charles Liberman ◽  
Sharon G. Kujawa
Keyword(s):  
Hearing Loss ◽  
Cochlear Nerve ◽  
Threshold Shift ◽  
Nerve Degeneration ◽  
Hidden Hearing Loss

Are reports of temporary threshold shift-like symptoms by humans with normal hearing associated with hidden hearing loss?

2017 ◽  
Vol 141 (5) ◽  
pp. 3814-3814 ◽  
Author(s):  
Anthony J. Brammer ◽  
Gongqiang Yu ◽  
James J. Grady ◽  
Kourosh Parham ◽  
Martin G. Cherniack ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Normal Hearing ◽  
Threshold Shift ◽  
Temporary Threshold Shift ◽  
Hidden Hearing Loss

An Evaluation of the Relationship between Retinal Nerve Fiber Thickness, Cochlear Nerve Thickness, the Level of Tinnitus, and Hearing Loss in Unilateral Tinnitus Patients

2021 ◽  
pp. 1-8
Author(s):  
Mustafa Avcu ◽  
Mehmet Metin ◽  
Raşit Kılıç ◽  
Muhammed Alpaslan
Keyword(s):  
Hearing Loss ◽  
Nerve Fiber ◽  
Normal Hearing ◽  
Cochlear Nerve ◽  
Significant Difference ◽  
The Relationship ◽  
Fiber Thickness ◽  
Moderate Hearing Loss ◽  
Group 1 ◽  
Retinal Nerve Fiber

Background: In this study, optic coherence tomography (OCT) examination was performed to check whether there was any interaction between ophthalmic axonal structures in unilateral tinnitus patients, and the relationship between optic nerve thickness and cochlear nerve thickness was evaluated. Objective: The aim of the study was to evaluate the relatioship between hearing loss, tinnitus, and nerve thicknesses. Study Design: Prospective study. Setting: Tertiary referral university hospital. Patients: The study included 88 patients with unilateral tinnitus, for which no organic cause could be found in physical examination, psychiatric evaluation, or with imaging methods. Study groups were formed of the tinnitus side and control groups were formed of the healthy side as follows: Group 1 (Non-tinnitus side normal hearing values – n = 30), Group 2 (non-tinnitus side minimal hearing loss – n = 27), Group 3 (non-tinnitus side moderate hearing loss – n = 31), Group 4 (tinnitus side normal hearing values – n = 25), Group 5 (tinnitus side minimal hearing loss – n = 25), and Group 6 (tinnitus side moderate hearing loss – n = 38). Intervention: Retinal nerve fiber layer (RNFL) thickness was evaluated with OCT, and the cochlear nerve cross-sectional area was evaluated with MRI. Main Outcome Measures: RNFL measurements were taken with OCT from the subfoveal area (RNFL-SF) and 1.5 mm temporal to the fovea (RNFL-T µm) and nasal (RNFL-N µm) sectors. On MRI, 3 measurements were taken along the nerve from the cerebellopontine angle as far as the internal auditory canal, and the mean value of these 3 measurements was calculated. Results: When the groups were evaluated in respect of cochlear nerve thickness, a significant difference was seen between Group 1 and both the groups with hearing loss and the tinnitus groups. In the subgroup analysis, a statistically significant difference was determined between Group 1 and Groups 3, 4, 5, and 6 (p = 0.013, p = 0.003, p < 0.001, and p < 0.001, respectively). When the groups were evaluated in respect of the RNFL-SF (µm), RNFL-T (µm), and RNFL-N (µm) values, the differences were determined to be statistically significant (p < 0.001 for all). In the correlation analysis, a negative correlation was determined between hearing loss and cochlear nerve diameter (r: −0.184, p = 0.014), and RNFL-N (r: −0.272, p < 0.001) and between tinnitus and cochlear nerve diameter (r: −0.536, p < 0.001), and RNFL-T (r: −0.222, p < 0.009). Conclusion: The study results clearly showed a relationship between cochlear nerve fiber thickness and hearing loss and the severity of tinnitus in cases with unilateral tinnitus and that there could be neurodegenerative factors in the disease etiology. A similar relationship seen with the RNFL supports the study hypothesis.

scholarly journals Cochlear Nerve Canal Stenosis: Association With MYH14 and MYH9 Genes

2021 ◽  
pp. 014556132199683
Author(s):  
Wenqi Liang ◽  
Line Wang ◽  
Xinyu Song ◽  
Fenqi Gao ◽  
Pan Liu ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Next Generation Sequencing ◽  
Inner Ear ◽  
Internal Auditory Canal ◽  
Cochlear Nerve ◽  
Transverse Diameter ◽  
Congenital Hearing Loss ◽  
Canal Stenosis ◽  
Ear Anomalies ◽  
Generation Sequencing

The bony cochlear nerve canal transmits the cochlear nerve as it passes from the fundus of the internal auditory canal to the cochlea. Stenosis of the cochlear nerve canal, defined as a diameter less than 1.0 mm in transverse diameter, is associated with inner ear anomalies and severe to profound congenital hearing loss. We describe an 11-month-old infant with nonsyndromic congenital sensorineural hearing loss with cochlear nerve canal stenosis. Next-generation sequencing revealed heterozygous mutations in MYH9 and MYH14, encoding for the inner ear proteins myosin heavy chain IIA and IIC. The patient’s hearing was rehabilitated with bilateral cochlear implantation.

scholarly journals Effect of Phlorofucofuroeckol A and Dieckol Extracted from Ecklonia cava on Noise-induced Hearing Loss in a Mouse Model

Marine Drugs ◽  
2021 ◽  
Vol 19 (8) ◽  
pp. 443
Author(s):  
Hyunjun Woo ◽  
Min-Kyung Kim ◽  
Sohyeon Park ◽  
Seung-Hee Han ◽  
Hyeon-Cheol Shin ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Hair Cell ◽  
Noise Exposure ◽  
Radical Scavenging ◽  
Threshold Shift ◽  
Ecklonia Cava ◽  
Control Group ◽  
Noise Induced Hearing Loss ◽  
Antioxidant Agents ◽  
Brainstem Response

One of the well-known causes of hearing loss is noise. Approximately 31.1% of Americans between the ages of 20 and 69 years (61.1 million people) have high-frequency hearing loss associated with noise exposure. In addition, recurrent noise exposure can accelerate age-related hearing loss. Phlorofucofuroeckol A (PFF-A) and dieckol, polyphenols extracted from the brown alga Ecklonia cava, are potent antioxidant agents. In this study, we investigated the effect of PFF-A and dieckol on the consequences of noise exposure in mice. In 1,1-diphenyl-2-picrylhydrazyl assay, dieckol and PFF-A both showed significant radical-scavenging activity. The mice were exposed to 115 dB SPL of noise one single time for 2 h. Auditory brainstem response(ABR) threshold shifts 4 h after 4 kHz noise exposure in mice that received dieckol were significantly lower than those in the saline with noise group. The high-PFF-A group showed a lower threshold shift at click and 16 kHz 1 day after noise exposure than the control group. The high-PFF-A group also showed higher hair cell survival than in the control at 3 days after exposure in the apical turn. These results suggest that noise-induced hair cell damage in cochlear and the ABR threshold shift can be alleviated by dieckol and PFF-A in the mouse. Derivatives of these compounds may be applied to individuals who are inevitably exposed to noise, contributing to the prevention of noise-induced hearing loss with a low probability of adverse effects.

Evaluation of Cochlear Nerve Imaging in Severe Congenital Sensorineural Hearing Loss

ORL ◽  
2007 ◽  
Vol 69 (3) ◽  
pp. 198-202 ◽  
Author(s):  
Sachiko Komatsubara ◽  
Atsushi Haruta ◽  
Yuki Nagano ◽  
Takao Kodama
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Cochlear Nerve ◽  
Sensorineural Hearing ◽  
Nerve Imaging

Loudness Growth under Masking: Relation to True Sensorineural Impairment

1973 ◽  
Vol 16 (4) ◽  
pp. 597-607 ◽  
Author(s):  
Alan M. Richards
Keyword(s):  
Hearing Loss ◽  
Power Function ◽  
Threshold Shift ◽  
Essential Difference ◽  
Frequency Dependent ◽  
Masker Level ◽  
Loudness Recruitment ◽  
The Family ◽  
Balance Functions ◽  
Loudness Growth

Alternate binaural loudness balances between masked and unmasked normal ears were performed to examine the growth of loudness as a function of masker level at each of several frequencies (500, 1000, 2000, and 4000 Hz) and to determine whether the recruitmentlike phenomenon in masked ears is comparable in its growth and form to actual recruitment growth in sensorineural impaired ears. The results for 28 subjects indicated that for all frequencies a power function relating the perceived loudness in the masked ear to the unmasked ear could be drawn, and that the slope of this function rose as a function of increased masking. The family of slopes for each frequency was linearly related to the induced threshold shift. The slope of this latter relation proved to be frequency dependent. Comparison between the slope growth in simulated hearing loss and the family of loudness-balance slopes obtained from patients with true unilateral loss of varying degree indicated that the slopes of loudness-balance functions in the latter group also increased linearly with increased loss. In this latter instance, however, the slope growth was not frequency dependent, thus pointing to an essential difference between simulated and actual loudness recruitment growth.

Unilateral cochlear nerve hypoplasia in children with mild to moderate hearing loss

2012 ◽  
Vol 132 (11) ◽  
pp. 1160-1167 ◽  
Author(s):  
Hidenobu Taiji ◽  
Noriko Morimoto ◽  
Tatsuo Matsunaga
Keyword(s):  
Hearing Loss ◽  
Cochlear Nerve ◽  
Cochlear Nerve Hypoplasia ◽  
Moderate Hearing Loss
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