A technique for monitoring and controlling cavitation activity during high intensity focused ultrasound application

2005 ◽  
Vol 117 (4) ◽  
pp. 2530-2530 ◽  
Author(s):  
Charles R. Thomas ◽  
Caleb H. Farny ◽  
Ronald A. Roy ◽  
R. Glynn Holt
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Ultrasound Application ◽  
Cavitation Activity

scholarly journals Investigation of the Inertial Cavitation Activity of Sonosensitive and Biocompatible Nanoparticles for Drug Delivery Applications Employing High Intensity Focused Ultrasound

2019 ◽  
Vol 5 (1) ◽  
pp. 585-588
Author(s):  
Benedikt George ◽  
Michael Fink ◽  
Helmut Ermert ◽  
Stefan J. Rupitsch ◽  
Pia T. Hiltl ◽  
...  
Keyword(s):  
Drug Release ◽  
High Intensity ◽  
Focused Ultrasound ◽  
Active Drug ◽  
Drug Carriers ◽  
High Intensity Focused Ultrasound ◽  
Activity Level ◽  
Inertial Cavitation ◽  
Cavitation Effect ◽  
Cavitation Activity

AbstractAn approach to improve chemotherapy, while minimizing side effects, is a local drug release close to the tumorous tissue. For this purpose, the active drug component is often bound to nanoparticles employed as drug carriers. In the present study, we investigate sonosensitive, biocompatible poly-(L)-lactic acid (PLA) nanoparticles, which shall be used as drug carriers. For drug release, High Intensity Focused Ultrasound (HIFU) will be employed to introduce inertial cavitation, which separates the active drug component from the drug carrier. The cavitation effect generates an acoustic noise signal, which characterizes the cavitation activity and is expected to serve simultaneously as an indicator for the release of the active drug component. Depending on the ultrasound frequency, different acoustic levels of the inertial cavitation activity were measured. Investigations using a setup for passive cavitation detection (PCD) deliver quantitative results regarding the frequency dependence of the cavitation activity level of nanoparticles and reference media.

Effect of high intensity focused ultrasound transducer F-number and waveform non-linearity on inertial cavitation activity

2018 ◽  
Vol 144 (3) ◽  
pp. 1824-1824 ◽  
Author(s):  
Christopher Bawiec ◽  
Christopher Hunter ◽  
Wayne Kreider ◽  
Adam D. Maxwell ◽  
Vera A. Khokhlova ◽  
...  
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Ultrasound Transducer ◽  
Inertial Cavitation ◽  
Cavitation Activity

Dependence of inertial cavitation activity on the high intensity focused ultrasound transducer F-number

2016 ◽  
Vol 140 (4) ◽  
pp. 2983-2983
Author(s):  
Tatiana Khokhlova ◽  
Christopher Hunter ◽  
Wayne Kreider ◽  
Adam Maxwell ◽  
Vera Khokhlova ◽  
...  
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Ultrasound Transducer ◽  
Inertial Cavitation ◽  
Cavitation Activity

scholarly journals Dynamics and control of cavitation during high-intensity focused ultrasound application

2005 ◽  
Vol 6 (3) ◽  
pp. 182-187 ◽  
Author(s):  
Charles R. Thomas ◽  
Caleb H. Farny ◽  
Constantin C. Coussios ◽  
Ronald A. Roy ◽  
R. Glynn Holt
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Dynamics And Control ◽  
Ultrasound Application ◽  
And Control

scholarly journals Enhancement and quenching of high-intensity focused ultrasound cavitation activity via short frequency sweep gaps

2016 ◽  
Vol 29 ◽  
pp. 194-197 ◽  
Author(s):  
Loïc Hallez ◽  
Judy Lee ◽  
Francis Touyeras ◽  
Aymeric Nevers ◽  
Muthupandian Ashokkumar ◽  
...  
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Frequency Sweep ◽  
Cavitation Activity
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