Physiological studies of the precedence effect in the inferior colliculus of the kitten

1998 ◽  
Vol 103 (6) ◽  
pp. 3139-3152 ◽  
Author(s):  
Ruth Y. Litovsky
Keyword(s):  
Inferior Colliculus ◽  
Precedence Effect ◽  
Physiological Studies

Physiological Studies of the Precedence Effect in the Inferior Colliculus of the Cat. II. Neural Mechanisms

1998 ◽  
Vol 80 (3) ◽  
pp. 1302-1316 ◽  
Author(s):  
Ruth Y. Litovsky ◽  
Tom C. T. Yin
Keyword(s):  
Inferior Colliculus ◽  
Free Field ◽  
Neural Mechanisms ◽  
Precedence Effect ◽  
Medial Superior Olive ◽  
Mixed Effect ◽  
Source Level ◽  
Physiological Studies ◽  
Interaural Differences ◽  
Lead Location

Litovsky, Ruth Y. and Tom C. T. Yin. Physiological studies of the precedence effect in the inferior colliculus of the cat. II. Neural mechanisms. J. Neurophysiol. 80: 1302–1316, 1998. We studied the responses of neurons in the inferior colliculus (IC) of cats to stimuli known to evoke the precedence effect (PE). This paper focuses on stimulus conditions that probe the neural mechanisms underlying the PE but that are not usually encountered in a natural situation. Experiments were conducted under both free-field (anechoic chamber) and dichotic (headphones) conditions. We found that in free field the amount of suppression of the lagging response depended on the location of the leading source. With stimuli in the azimuthal plane, the majority (84%) of units showed stronger suppression of the lagging response for a leading stimulus placed in the cell's responsive area as compared with a lead in the unresponsive field. A smaller number of units showed stronger suppression for a lead placed in the unresponsive field, and a few showed little effect of the lead location. In the elevational plane, there was less sensitivity of the leading source to changes in location, but for those cells in which there was sensitivity, suppression was always stronger when the lead was in the cell's responsive area. Studies on stimulus locations also were conducted under dichotic conditions by varying the interaural differences in time (ITD) of the leading source. Results were consistent with those obtained in free field, suggesting that ITDs play an important role in determining the amount of suppression that was observed as a function of leading stimulus location. In addition to location and ITD, we also studied the effect of varying the relative levels of the lead and lag as well as stimulus duration. For all units studied, increasing the level of the leading stimulus while holding the lagging stimulus constant resulted in increased suppression. Similar effects of leading source level were observed in azimuth and elevation. The effect of varying the duration of the leading source also showed that longer duration stimuli produce stronger suppression; this finding was observed both in azimuth and elevation. We also compared the suppression observed under binaural and monaural contralateral conditions and found a mixed effect: some neurons show stronger suppression under binaural conditions, others to monaural contralateral conditions, and still others show no effect. The results presented here support the hypothesis that the PE reflects a long-lasting inhibition evoked by the leading stimulus. Five possible sources for the inhibition are considered: the auditory nerve, intrinsic circuits in the cochlear nucleus, medial and lateral nuclei of the trapezoid body inhibition to the medial superior olive, dorsal nucleus of the lateral lemniscus (DNLL) inhibition to the ICC, and intrinsic circuits in the ICC itself.

scholarly journals Physiological Studies of the Precedence Effect in the Inferior Colliculus of the Cat. I. Correlates of Psychophysics

1998 ◽  
Vol 80 (3) ◽  
pp. 1285-1301 ◽  
Author(s):  
Ruth Y. Litovsky ◽  
Tom C. T. Yin
Keyword(s):  
Inferior Colliculus ◽  
Free Field ◽  
Median Plane ◽  
Stimulus Level ◽  
Central Nucleus ◽  
Precedence Effect ◽  
Discharge Rates ◽  
Physiological Studies ◽  
Echo Suppression ◽  
Maximal Suppression

Litovsky, Ruth Y. and Tom C. T. Yin. Physiological studies of the precedence effect in the inferior colliculus of the cat. I. Correlates of psychophysics. J. Neurophysiol. 80: 1285–1301, 1998. The precedence effect (PE) is experienced when two spatially separated sounds are presented with such a brief delay that only a single auditory image at or toward the location of the leading source is perceived. The responses of neurons in the central nucleus of the inferior colliculus (ICC) of cats were studied using stimuli that are known to elicit the PE, focusing on the effects of changes in stimulus conditions that a listener might encounter in a natural situation. Experiments were conducted under both free-field (anechoic chamber) and dichotic (headphones) conditions. In free field, the PE was simulated by presenting two sounds from different loudspeakers with one sound delayed relative to the other. Either click or noise stimuli (2- to 10-ms duration) were used. Dichotically, the same conditions were simulated by presenting two click or noise pairs separated by an interstimulus delay (ISD) with interaural time differences (ITDs) imposed separately for each pair. At long ISDs, all neurons responded to both leading and lagging sources as if they were delivered alone. As the ISDs were shortened, the lagging response became suppressed. The ISD of half-maximal suppression varied considerably within the population of neurons studied, ranging from 2 to 100 ms, with means of 35 and 38 ms for free field and dichotic conditions, respectively. Several correlates of psychophysical findings were observed in ICC neurons: suppression was usually stronger with lower overall stimulus level and longer duration stimuli. Suppression also was compared along the azimuth and elevation in free field by placing the lagging source at (0°,0°), which is common to both axes, and the leading sources at locations along either plane that generated similar discharge rates. All neurons that showed suppression along the azimuth also did so in the elevation. In addition, there was a high correlation in the ISD of half-maximal suppression along the two planes ( r = 0.87). These findings suggest that interaural difference cues, which are robust along the horizontal axis but minimal in the median plane, are not necessary for neural correlates of the PE to be manifested. Finally, single-neuron responses did not demonstrate a correlate of build-up of suppression, a phenomenon whereby echo suppression accumulates with ongoing stimulation. This finding adds credibility to theories about the PE that argue for a “higher order” component of the PE.

scholarly journals Local inhibition of GABA affects precedence effect in the inferior colliculus

2014 ◽  
Vol 9 (4) ◽  
pp. 420 ◽  
Author(s):  
Ningyu Wang ◽  
Dan Wang ◽  
Jun Jia ◽  
Jinfeng Liu ◽  
Yan Xie ◽  
...  
Keyword(s):  
Inferior Colliculus ◽  
Precedence Effect ◽  
Local Inhibition

Modeling the precedence effect in inferior colliculus neurons using converging excitatory and inhibitory inputs

2008 ◽  
Vol 123 (5) ◽  
pp. 3296-3296
Author(s):  
Jing Xia ◽  
Andrew Brughera ◽  
H Steven Colburn ◽  
Barbara Shinn‐Cunningham
Keyword(s):  
Inferior Colliculus ◽  
Precedence Effect

Neural Correlates of the Precedence Effect in the Inferior Colliculus of Behaving Cats

2004 ◽  
Vol 92 (6) ◽  
pp. 3286-3297 ◽  
Author(s):  
Daniel J. Tollin ◽  
Luis C. Populin ◽  
Tom C. T. Yin
Keyword(s):  
Inferior Colliculus ◽  
Sound Localization ◽  
Species Differences ◽  
Behavioral Responses ◽  
Neural Correlates ◽  
Precedence Effect ◽  
Single Neurons ◽  
Localization Dominance ◽  
Echo Threshold ◽  
Spatial Locations

Several auditory spatial illusions, collectively called the precedence effect (PE), occur when transient sounds are presented from two different spatial locations but separated in time by an interstimulus delay (ISD). For ISDs in the range of localization dominance (<10 ms), a single fused sound is typically located near the leading source location only, as if the location of the lagging source were suppressed. For longer ISDs, both the leading and lagging sources can be heard and localized, and the shortest ISD where this occurs is called the echo threshold. Previous physiological studies of the extracellular responses of single neurons in the inferior colliculus (IC) of anesthetized cats and unanesthetized rabbits with sounds known to elicit the PE have shown correlates of these phenomena though there were differences in the physiologically measured echo thresholds. Here we recorded in the IC of awake, behaving cats using stimuli that we have shown to evoke behavioral responses that are consistent with the precedence effect. For small ISDs, responses to the lag were reduced or eliminated consistent with psychophysical data showing that sound localization is based on the leading source. At longer ISDs, the responses to the lagging source recovered at ISDs comparable to psychophysically measured echo thresholds. Thus it appears that anesthesia, and not species differences, accounts for the discrepancies in the earlier studies.

Neural Correlates of the Precedence Effect in the Inferior Colliculus: Effect of Localization Cues

2002 ◽  
Vol 87 (2) ◽  
pp. 976-994 ◽  
Author(s):  
R. Y. Litovsky ◽  
B. Delgutte
Keyword(s):  
Inferior Colliculus ◽  
Time Course ◽  
Transfer Functions ◽  
Free Field ◽  
Field Studies ◽  
Suppressive Effect ◽  
Virtual Space ◽  
Precedence Effect ◽  
Excitatory Response ◽  
Accurate Localization

The precedence effect (PE) is an auditory phenomenon involved in suppressing the perception of echoes in reverberant environments, and is thought to facilitate accurate localization of sound sources. We investigated physiological correlates of the PE in the inferior colliculus (IC) of anesthetized cats, with a focus on directional mechanisms for this phenomenon. We used a virtual space (VS) technique, where two clicks (a “lead” and a “lag”) separated by a brief time delay were each filtered through head-related transfer functions (HRTFs). For nearly all neurons, the response to the lag was suppressed for short delays and recovered at long delays. In general, both the time course and the directional patterns of suppression resembled those reported in free-field studies in many respects, suggesting that our VS simulation contained the essential cues for studying PE phenomena. The relationship between the directionality of the response to the lead and that of its suppressive effect on the lag varied a great deal among IC neurons. For a majority of units, both excitation produced by the lead and suppression of the lag response were highly directional, and the two were similar to one another. For these neurons, the long-lasting inhibitory inputs thought to be responsible for suppression seem to have similar spatial tuning as the inputs that determine the excitatory response to the lead. Further, the behavior of these neurons is consistent with psychophysical observations that the PE is strongest when the lead and the lag originate from neighboring spatial locations. For other neurons, either there was no obvious relationship between the directionality of the excitatory lead response and the directionality of suppression, or the suppression was highly directional whereas the excitation was not, or vice versa. For these neurons, the excitation and the suppression produced by the lead seem to depend on different mechanisms. Manipulation of the directional cues (such as interaural time and level differences) contained in the lead revealed further dissociations between excitation and suppression. Specifically, for about one-third of the neurons, suppression depended on different directional cues than did the response to the lead, even though the directionality of suppression was similar to that of the lead response when all cues were present. This finding suggests that the inhibitory inputs causing suppression may originate in part from subcollicular auditory nuclei processing different directional cues than the inputs that determine the excitatory response to the lead. Neurons showing such dissociations may play an important role in the PE when the lead and the lag originate from very different directions.

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