Inner hair cell and organ of Corti responses to very low frequency tones.

1996 ◽  
Vol 99 (4) ◽  
pp. 2583-2603
Author(s):  
M. A. Cheatham ◽  
P. Dallos
Keyword(s):  
Hair Cell ◽  
Low Frequency ◽  
Organ Of Corti ◽  
Inner Hair Cell ◽  
Very Low Frequency

scholarly journals THE ULTRASTRUCTURE OF THE SENSORY HAIRS AND ASSOCIATED ORGANELLES OF THE COCHLEAR INNER HAIR CELL, WITH REFERENCE TO DIRECTIONAL SENSITIVITY

1966 ◽  
Vol 29 (3) ◽  
pp. 497-505 ◽  
Author(s):  
Arndt J. Duvall ◽  
Åke Flock ◽  
Jan Wersäll
Keyword(s):  
Guinea Pig ◽  
Hair Cell ◽  
Basal Body ◽  
Organ Of Corti ◽  
Sensory Cells ◽  
Directional Sensitivity ◽  
Inner Hair Cell ◽  
Lateral Line Organ ◽  
Sensory Hairs ◽  
Line Organ

From the apical end of the inner hair cell of the organ of Corti in the guinea pig cochlea protrude four to five rows of stereocilia shaped in a pattern not unlike the wings of a bird. In the area devoid of cuticular substance facing toward the tunnel of Corti lies a consistently present centriole. The ultrastructure of this centriole is similar to that of the basal body of the kinocilium located in the periphery of the sensory hair bundles in the vestibular and lateral line organ sensory cells and to that of the centrioles of other cells. The physiological implications of the anatomical orientation of this centriole are discussed in terms of directional sensitivity.

scholarly journals Inner hair cell dysfunction in Klhl18 mutant mice leads to low frequency progressive hearing loss

PLoS ONE ◽  
2021 ◽  
Vol 16 (10) ◽  
pp. e0258158
Author(s):  
Neil J. Ingham ◽  
Navid Banafshe ◽  
Clarisse Panganiban ◽  
Julia L. Crunden ◽  
Jing Chen ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Hair Cell ◽  
Cell Function ◽  
Low Frequency ◽  
Mutant Mice ◽  
Auditory Brainstem Responses ◽  
Distortion Product Otoacoustic Emission ◽  
Inner Hair Cell ◽  
Distortion Product ◽  
Age Related

Age-related hearing loss in humans (presbycusis) typically involves impairment of high frequency sensitivity before becoming progressively more severe at lower frequencies. Pathologies initially affecting lower frequency regions of hearing are less common. Here we describe a progressive, predominantly low-frequency recessive hearing impairment in two mutant mouse lines carrying different mutant alleles of the Klhl18 gene: a spontaneous missense mutation (Klhl18lowf) and a targeted mutation (Klhl18tm1a(KOMP)Wtsi). Both males and females were studied, and the two mutant lines showed similar phenotypes. Threshold for auditory brainstem responses (ABR; a measure of auditory nerve and brainstem neural activity) were normal at 3 weeks old but showed progressive increases from 4 weeks onwards. In contrast, distortion product otoacoustic emission (DPOAE) sensitivity and amplitudes (a reflection of cochlear outer hair cell function) remained normal in mutants. Electrophysiological recordings from the round window of Klhl18lowf mutants at 6 weeks old revealed 1) raised compound action potential thresholds that were similar to ABR thresholds, 2) cochlear microphonic potentials that were normal compared with wildtype and heterozygous control mice and 3) summating potentials that were reduced in amplitude compared to control mice. Scanning electron microscopy showed that Klhl18lowf mutant mice had abnormally tapering of the tips of inner hair cell stereocilia in the apical half of the cochlea while their synapses appeared normal. These results suggest that Klhl18 is necessary to maintain inner hair cell stereocilia and normal inner hair cell function at low frequencies.

Reciprocal synapses between inner hair cell spines and afferent dendrites in the organ of corti of the mouse

Synapse ◽  
2003 ◽  
Vol 50 (1) ◽  
pp. 53-66 ◽  
Author(s):  
Hanna M. Sobkowicz ◽  
Susan M. Slapnick ◽  
Benjamin K. August
Keyword(s):  
Hair Cell ◽  
Organ Of Corti ◽  
Inner Hair Cell
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