Reciprocal synapses between inner hair cell spines and afferent dendrites in the organ of corti of the mouse

Synapse ◽  
2003 ◽  
Vol 50 (1) ◽  
pp. 53-66 ◽  
Author(s):  
Hanna M. Sobkowicz ◽  
Susan M. Slapnick ◽  
Benjamin K. August
Keyword(s):  
Hair Cell ◽  
Organ Of Corti ◽  
Inner Hair Cell

scholarly journals THE ULTRASTRUCTURE OF THE SENSORY HAIRS AND ASSOCIATED ORGANELLES OF THE COCHLEAR INNER HAIR CELL, WITH REFERENCE TO DIRECTIONAL SENSITIVITY

1966 ◽  
Vol 29 (3) ◽  
pp. 497-505 ◽  
Author(s):  
Arndt J. Duvall ◽  
Åke Flock ◽  
Jan Wersäll
Keyword(s):  
Guinea Pig ◽  
Hair Cell ◽  
Basal Body ◽  
Organ Of Corti ◽  
Sensory Cells ◽  
Directional Sensitivity ◽  
Inner Hair Cell ◽  
Lateral Line Organ ◽  
Sensory Hairs ◽  
Line Organ

From the apical end of the inner hair cell of the organ of Corti in the guinea pig cochlea protrude four to five rows of stereocilia shaped in a pattern not unlike the wings of a bird. In the area devoid of cuticular substance facing toward the tunnel of Corti lies a consistently present centriole. The ultrastructure of this centriole is similar to that of the basal body of the kinocilium located in the periphery of the sensory hair bundles in the vestibular and lateral line organ sensory cells and to that of the centrioles of other cells. The physiological implications of the anatomical orientation of this centriole are discussed in terms of directional sensitivity.

scholarly journals A flexible anatomical set of mechanical models for the organ of Corti

2021 ◽  
Vol 8 (9) ◽  
pp. 210016
Author(s):  
Jorge Berger ◽  
Jacob Rubinstein
Keyword(s):  
Hair Cell ◽  
Mechanical Response ◽  
Outer Hair Cell ◽  
Basilar Membrane ◽  
Signal To Noise Ratio ◽  
Equations Of Motion ◽  
Fluid Motion ◽  
Organ Of Corti ◽  
Outer Hair Cells ◽  
Inner Hair Cell

We build a flexible platform to study the mechanical operation of the organ of Corti (OoC) in the transduction of basilar membrane (BM) vibrations to oscillations of an inner hair cell bundle (IHB). The anatomical components that we consider are the outer hair cells (OHCs), the outer hair cell bundles, Deiters cells, Hensen cells, the IHB and various sections of the reticular lamina. In each of the components we apply Newton’s equations of motion. The components are coupled to each other and are further coupled to the endolymph fluid motion in the subtectorial gap. This allows us to obtain the forces acting on the IHB, and thus study its motion as a function of the parameters of the different components. Some of the components include a nonlinear mechanical response. We find that slight bending of the apical ends of the OHCs can have a significant impact on the passage of motion from the BM to the IHB, including critical oscillator behaviour. In particular, our model implies that the components of the OoC could cooperate to enhance frequency selectivity, amplitude compression and signal to noise ratio in the passage from the BM to the IHB. Since the model is modular, it is easy to modify the assumptions and parameters for each component.

scholarly journals A flexible anatomic set of mechanical models for the organ of Corti

2019 ◽  
Author(s):  
Jorge Berger ◽  
Jacob Rubinstein
Keyword(s):  
Hair Cell ◽  
Outer Hair Cell ◽  
Basilar Membrane ◽  
Mechanical Performance ◽  
Signal To Noise Ratio ◽  
Fluid Motion ◽  
Organ Of Corti ◽  
Outer Hair Cells ◽  
Inner Hair Cell ◽  
Mechanical Models

We build a flexible platform for the study of the mechanical performance of the organ of Corti (OoC) in the transduction of basilar membrane (BM) vibrations to motion of an inner hair cell bundle (IHB). In this platform, each anatomic component of the OoC is described by an equation of motion that can be followed in time. We propose an initial set of models that attempt to capture the nonlinearities of somatic and bundle motility, but can nevertheless be easily handled. The anatomic components that we consider are the outer hair cells (OHCs), the outer hair cell bundles, Deiters cells, Hensen cells, the IHB and various sections of the reticular lamina. We study endolymph fluid motion in the subtectorial gap and then the mutual interactions among the components of the OoC, including the pressure exerted by endolymph. Minute bending of the apical ends of the OHCs can have a significant impact on the passage of motion from the BM to the IHB, including possible critical oscillator behaviour, even without the assistance of tectorial motion, shearing, or bundle motility. Thus, the components of the OoC could cooperate to enhance frequency selectivity, amplitude compression and signal to noise ratio in the passage from the BM to the IHB. Our models also provide a mechanism that could contribute to appropriate amplification of the wave travelling along the cochlea.

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