AP tuning curves from normal and pathological human and guinea pig cochleas

1981 ◽  
Vol 69 (5) ◽  
pp. 1374-1385 ◽  
Author(s):  
Robert V. Harrison ◽  
Jean–Marie Aran ◽  
Jean–Paul Erre
Keyword(s):  
Guinea Pig ◽  
Tuning Curves

A comparison of AP and ABR tuning curves in the guinea pig

1987 ◽  
Vol 25 (2-3) ◽  
pp. 193-204 ◽  
Author(s):  
Carolyn J. Browri ◽  
Paul J. Abbas
Keyword(s):  
Guinea Pig ◽  
Tuning Curves

Tuning curves of cochlear and brainstem responses in the guinea pig

1980 ◽  
Vol 68 (3) ◽  
pp. 896-900 ◽  
Author(s):  
Curt Mitchell ◽  
Cynthia Fowler
Keyword(s):  
Guinea Pig ◽  
Tuning Curves

Tuning curves of brainstem potentials in the guinea pig

1977 ◽  
Vol 61 (S1) ◽  
pp. S75-S75
Author(s):  
Curt Mitchell ◽  
Cynthia G. Fowler
Keyword(s):  
Guinea Pig ◽  
Tuning Curves

Electrical Tuning Curves of the Guinea‐Pig Cochlea

1966 ◽  
Vol 40 (5) ◽  
pp. 1274-1274
Author(s):  
C. A. Laszlo ◽  
R. Patrick Gannon ◽  
David H. Moscovitch
Keyword(s):  
Guinea Pig ◽  
Tuning Curves ◽  
Guinea Pig Cochlea

Basilar membrane tuning curves in the guinea pig

1974 ◽  
Vol 55 (3) ◽  
pp. 584-587 ◽  
Author(s):  
Brian M. Johnstone ◽  
Graeme K. Yates
Keyword(s):  
Guinea Pig ◽  
Basilar Membrane ◽  
Tuning Curves

off Responses in the Auditory Thalamus of the Guinea Pig

2002 ◽  
Vol 88 (5) ◽  
pp. 2377-2386 ◽  
Author(s):  
Jufang He
Keyword(s):  
Guinea Pig ◽  
Frequency Tuning ◽  
Medial Geniculate Body ◽  
Noise Burst ◽  
Border Region ◽  
Tuning Curves ◽  
Auditory Thalamus ◽  
Auditory Responses ◽  
Medial Geniculate ◽  
The Mean

on and off auditory responses were examined in the medial geniculate body (MGB) of the guinea pig. Single- and multiunit recordings were carried out on 12 anesthetized animals, and noise-burst or pure-tone stimuli were applied to the ear contralateral to the recording hemisphere. One hundred and thirty-fiveoff or on-off neurons and 160 onneurons were studied, and the tuning curves of 21 on-off oroff neurons were examined from various nuclei of the MGB. The mean minimum threshold of the off responses (40.8 ± 20.0 dB SPL, mean ± SD; range: 0–80 dB SPL) was significantly higher than that of the on responses (28.5 ± 17.6 dB SPL, range: 0–60 dB SPL; n = 17, P < 0.001). Of 10 on-off neurons that showed identifiable tuning frequencies for both on andoff responses, 7 showed a higher off thanon best frequency (BF), 2 showed the same BF for bothon and off, and only 1 showed a slightly loweroff than on BF. Most off responses sampled from the borders of the ventral (MGv) and the rostromedial (MGrm) nuclei of the MGB showed single-peaked tuning curves, similar to those of the on responses in the MGv. The neurons located in the shell (MGs) and dorsal (MGd) nuclei of the MGB showed complicated—either multi-peaked or broad—tuning curves. Alloff responses showed long-duration-selectivity for acoustic stimuli: the mean half-maximum duration was 116.5 ± 114.8 ms ( n = 19, range: 27–411 ms). The latencies of 135off responses were studied in various divisions of the MGB. The ventral border region of MGv showed the shortest latency, followed by the dorsal border region of the MGv, the MGrm, and the caudomedial nucleus (MGcm) of the MGB. The posterior nucleus of the thalamus (Po), the MGd, and the MGs showed much longer mean latencies of >30 ms ( P < 0.05 compared with the border regions of the MGv, ANOVA), with Po showing the greatest mean latency of 60.3 ms and the greatest deviation of 25.5 ms). The latency of the offresponse (29.0 ± 14.0 ms, n = 135) was significantly greater than that of the on response (15.6 ± 9.6 ms, n = 160, P < 0.001). The present results provide valuable information about the threshold, frequency tuning characteristics, minimal response latency, and duration selectivity of off neurons in the auditory thalamus.

Effect of Contraceptive Steroids on the Endometrium of Guinea Pig: SEM study

1977 ◽  
Vol 35 ◽  
pp. 668-669
Author(s):  
Mai M. Said ◽  
Ramesh K. Nayak ◽  
Randall E. McCoy
Keyword(s):  
Guinea Pig ◽  
Reproductive Tract ◽  
Three Dimensional ◽  
Female Reproductive Tract ◽  
Human Female ◽  
Surface Ultrastructure ◽  
Transmission Electron ◽  
Sem Study ◽  
Uterine Mucosa ◽  
Group 1

Burgos and Wislocki described changes in the mucosa of the guinea pig uterus, cervix and vagina during the estrous cycle investigated by transmission electron microscopy. More recently, Moghissi and Reame reported the effects of progestational agents on the human female reproductive tract. They found drooping and shortening of cilia in norgestrel and norethindrone- treated endometria. To the best of our knowledge, no studies concerning the effects of mestranol and norethindrone given concurrently on the three-dimensional surface features on the uterine mucosa of the guinea pig have been reported. The purpose of this study was to determine the effect of mestranol and norethindrone on surface ultrastructure of guinea pig uterus by SEM.Seventy eight animals were used in this study. They were allocated into two groups. Group 1 (20 animals) was injected intramuscularly 0.1 ml vegetable oil and served as controls.

Ultrastructure and Drug Metabolism in the Developing Guinea Pig

1973 ◽  
Vol 31 ◽  
pp. 538-539
Author(s):  
W. Kuenzig ◽  
M. Boublik ◽  
J.J. Kamm ◽  
J.J. Burns
Keyword(s):  
Guinea Pig ◽  
Metabolic Activity ◽  
Animal Species ◽  
Adult Animal ◽  
Smooth Endoplasmic Reticulum ◽  
Fetal Life ◽  
Mixed Function Oxidase ◽  
Cytochrome P 450 ◽  
Microsomal Mixed Function Oxidase ◽  
Mixed Function Oxidase Activity

Unlike a variety of other animal species, such as the rabbit, mouse or rat, the guinea pig has a relatively long gestation period and is a more fully developed animal at birth. Kuenzig et al. reported that drug metabolic activity which increases very slowly during fetal life, increases rapidly after birth. Hepatocytes of a 3-day old neonate metabolize drugs and reduce cytochrome P-450 at a rate comparable to that observed in the adult animal. Moreover the administration of drugs like phenobarbital to pregnant guinea pigs increases the microsomal mixed function oxidase activity already in the fetus.Drug metabolic activity is, generally, localized within the smooth endoplasmic reticulum (SER) of the hepatocyte.

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