Basilar membrane tuning curves in the guinea pig

1974 ◽  
Vol 55 (3) ◽  
pp. 584-587 ◽  
Author(s):  
Brian M. Johnstone ◽  
Graeme K. Yates
Keyword(s):  
Guinea Pig ◽  
Basilar Membrane ◽  
Tuning Curves

AP tuning curves from normal and pathological human and guinea pig cochleas

1981 ◽  
Vol 69 (5) ◽  
pp. 1374-1385 ◽  
Author(s):  
Robert V. Harrison ◽  
Jean–Marie Aran ◽  
Jean–Paul Erre
Keyword(s):  
Guinea Pig ◽  
Tuning Curves

A comparison of AP and ABR tuning curves in the guinea pig

1987 ◽  
Vol 25 (2-3) ◽  
pp. 193-204 ◽  
Author(s):  
Carolyn J. Browri ◽  
Paul J. Abbas
Keyword(s):  
Guinea Pig ◽  
Tuning Curves

scholarly journals Vibration of the organ of Corti within the cochlear apex in mice

2014 ◽  
Vol 112 (5) ◽  
pp. 1192-1204 ◽  
Author(s):  
Simon S. Gao ◽  
Rosalie Wang ◽  
Patrick D. Raphael ◽  
Yalda Moayedi ◽  
Andrew K. Groves ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Phase Difference ◽  
Basilar Membrane ◽  
Organ Of Corti ◽  
Lateral Compartment ◽  
Outer Hair Cells ◽  
Supporting Cells ◽  
Tuning Curves ◽  
Cochlear Amplification

The tonotopic map of the mammalian cochlea is commonly thought to be determined by the passive mechanical properties of the basilar membrane. The other tissues and cells that make up the organ of Corti also have passive mechanical properties; however, their roles are less well understood. In addition, active forces produced by outer hair cells (OHCs) enhance the vibration of the basilar membrane, termed cochlear amplification. Here, we studied how these biomechanical components interact using optical coherence tomography, which permits vibratory measurements within tissue. We measured not only classical basilar membrane tuning curves, but also vibratory responses from the rest of the organ of Corti within the mouse cochlear apex in vivo. As expected, basilar membrane tuning was sharp in live mice and broad in dead mice. Interestingly, the vibratory response of the region lateral to the OHCs, the “lateral compartment,” demonstrated frequency-dependent phase differences relative to the basilar membrane. This was sharply tuned in both live and dead mice. We then measured basilar membrane and lateral compartment vibration in transgenic mice with targeted alterations in cochlear mechanics. Prestin499/499, Prestin−/−, and TectaC1509G/C1509G mice demonstrated no cochlear amplification but maintained the lateral compartment phase difference. In contrast, SfswapTg/Tg mice maintained cochlear amplification but did not demonstrate the lateral compartment phase difference. These data indicate that the organ of Corti has complex micromechanical vibratory characteristics, with passive, yet sharply tuned, vibratory characteristics associated with the supporting cells. These characteristics may tune OHC force generation to produce the sharp frequency selectivity of mammalian hearing.

M6-2 In vivo investigation on stimulating performances of MEMS fabricated basilar membrane for artificial cochlea using guinea pig (M6 Bio Sensor and System)

2009 ◽  
Vol 2009.1 (0) ◽  
pp. 97-98
Author(s):  
Yohei NAKAMOTO ◽  
Hirofumi SHINTAKU ◽  
Takatoshi INAOKA ◽  
Takayuki NAKAGAWA ◽  
Juichi ITO ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Basilar Membrane
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