scholarly journals Technical Note: A new TLD-phantom measurement system for determining dose distribution levels in the right and left breast from spiral CT chest imaging

2002 ◽  
Vol 3 (4) ◽  
pp. 324 ◽  
Author(s):  
Jeffery L. Hall
Keyword(s):  
Measurement System ◽  
Dose Distribution ◽  
Spiral Ct ◽  
Left Breast ◽  
Technical Note ◽  
Chest Imaging ◽  
Phantom Measurement ◽  
The Right

scholarly journals Bilateral Phyllodes Giant Tumor. A Case Report Analyzed by Array-CGH

Diagnostics ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 825
Author(s):  
Francesco Fortarezza ◽  
Federica Pezzuto ◽  
Gerardo Cazzato ◽  
Clelia Punzo ◽  
Antonio d’Amati ◽  
...  
Keyword(s):  
Array Cgh ◽  
Phyllodes Tumor ◽  
Molecular Classification ◽  
Left Breast ◽  
Comparative Genomic ◽  
Fish Analysis ◽  
Molecular Tests ◽  
Giant Tumor ◽  
Metastatic Risk ◽  
The Right

The breast phyllodes tumor is a biphasic tumor that accounts for less than of 1% of all breast neoplasms. It is classified as benign, borderline, or malignant, and can mimic benign masses. Some recurrent alterations have been identified. However, a precise molecular classification of these tumors has not yet been established. Herein, we describe a case of a 43-year-old woman that was admitted to the emergency room for a significant bleeding from the breast skin. A voluminous ulcerative mass of the left breast and multiple nodules with micro-calcifications on the right side were detected at a physical examination. A left total mastectomy and a nodulectomy of the right breast was performed. The histological diagnosis of the surgical specimens reported a bilateral giant phyllodes tumor, showing malignant features on the left and borderline characteristics associated with a fibroadenoma on the right. A further molecular analysis was carried out by an array-Comparative Genomic Hybridization (CGH) to characterize copy-number alterations. Many losses were detected in the malignant mass, involving several tumor suppressor genes. These findings could explain the malignant growth and the metastatic risk. In our study, genomic profiling by an array-CGH revealed a greater chromosomal instability in the borderline mass (40 total defects) than in the malignant (19 total defects) giant phyllodes tumor, reflecting the tumor heterogeneity. Should our results be confirmed with more sensitive and specific molecular tests (DNA sequencing and FISH analysis), they could allow a better selection of patients with adverse pathological features, thus optimizing and improving patient’s management.

scholarly journals Percutaneous C-Arm Free O-Arm Navigated Biopsy for Spinal Pathologies: A Technical Note

Diagnostics ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 636
Author(s):  
Masato Tanaka ◽  
Sumeet Sonawane ◽  
Koji Uotani ◽  
Yoshihiro Fujiwara ◽  
Kittipong Sessumpun ◽  
...  
Keyword(s):  
Histopathological Examination ◽  
Correct Diagnosis ◽  
Standard Technique ◽  
Percutaneous Biopsy ◽  
Technical Note ◽  
Spinal Tumors ◽  
Histopathological Diagnosis ◽  
Ct Guided ◽  
Ct Guided Biopsy ◽  
The Right

Background: Percutaneous biopsy under computed tomography (CT) guidance is a standard technique to obtain a definitive diagnosis when spinal tumors, metastases or infections are suspected. However, specimens obtained using a needle are sometimes inadequate for correct diagnosis. This report describes a unique biopsy technique which is C-arm free O-arm navigated using microforceps. This has not been previously described as a biopsy procedure. Case description: A 74-year-old man with T1 vertebra pathology was referred to our hospital with muscle weakness of the right hand, clumsiness and cervicothoracic pain. CT-guided biopsy was performed, but histopathological diagnosis could not be obtained due to insufficient tissue. The patient then underwent biopsy under O-arm navigation, so we could obtain sufficient tissue and small cell carcinoma was diagnosed on histopathological examination. A patient later received chemotherapy and radiation. Conclusions: C-arm free O-arm navigated biopsy is an effective technique for obtaining sufficient material from spine pathologies. Tissue from an exact pathological site can be obtained with 3-D images. This new O-arm navigation biopsy may provide an alternative to repeat CT-guided or open biopsy.

scholarly journals Endovascular plug for internal carotid artery occlusion in the management of a cavernous pseudoaneurysm with bifrontal subdural empyema: technical note

2017 ◽  
Vol 20 (3) ◽  
pp. 239-246
Author(s):  
Sunil Manjila ◽  
Gagandeep Singh ◽  
Obinna Ndubuizu ◽  
Zoe Jones ◽  
Daniel P. Hsu ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Internal Carotid Artery ◽  
Sphenoid Sinus ◽  
Internal Carotid ◽  
Balloon Catheter ◽  
Arterial Injury ◽  
Technical Note ◽  
Subdural Empyema ◽  
Artery Pseudoaneurysm ◽  
The Right

The authors demonstrate the use of an endovascular plug in securing a carotid artery pseudoaneurysm in an emergent setting requiring craniotomy for a concurrent subdural empyema.They describe the case of a 14-year-old boy with sinusitis and bifrontal subdural empyema who underwent transsphenoidal exploration at an outside hospital. An injury to the right cavernous segment of the ICA caused torrential epistaxis. Bleeding was successfully controlled by inflating a Foley balloon catheter within the sphenoid sinus, and the patient was transferred to the authors’ institution. Emergent angiography showed a dissection of the right cavernous carotid artery, with a large pseudoaneurysm projecting into the sphenoid sinus at the site of arterial injury. The right internal carotid artery was obliterated using pushable coils distally and an endovascular plug proximally. The endovascular plug enabled the authors to successfully exclude the pseudoaneurysm from the circulation. The patient subsequently underwent an emergent bifrontal craniotomy for evacuation of a left frontotemporal subdural empyema and exenteration of both frontal sinuses. He made a complete neurological recovery.Endovascular large-vessel sacrifice, obviating the need for numerous coils and antiplatelet therapy, has a role in the setting of selected acute neurosurgical emergencies necessitating craniotomy. The endovascular plug is a useful adjunct in such circumstances as the device can be deployed rapidly, safely, and effectively.

Predominance of RAD21 and ERBB2 amplification and progesterone receptor positivity in tumors of the right breast support breast cancer lateralization.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e12557-e12557
Author(s):  
Zachary Spigelman ◽  
Jo-Ellen Murphy
Keyword(s):  
Breast Cancer ◽  
Progesterone Receptor ◽  
Cancer Patients ◽  
Breast Tumors ◽  
Left Breast ◽  
Breast Cancers ◽  
Her2 Expression ◽  
Breast Cancer Patients ◽  
The Right ◽  
Chi Square Analysis

e12557 Background: Biologic lateralization broadly impacts breast cancer. Malignancies originating in the left breast compared to the right breast tend to be more frequent, larger and of poorer prognosis. Left breast tumors respond differently to HER2-neu signaling and have lateralized Ki67 expression. In a prior study a right-left asymmetry in the neutrophil/lymphocyte ratio (NLR) of breast cancers was identified (ASCO 2018, e13094). As a follow-up, retrospective analysis of results from comprehensive genomic profiling (CGP) of right and left side breast cancer specimens was performed to determine a potential genomic etiology for the observed NLR lateralization. Methods: Tumors from 43 consecutive breast cancer patients underwent analysis for all classes of genomic alterations by hybrid capture-based CGP (Foundation Medicine). The CGP results from the 25 left- and 18 right-sided breast cancer samples were analyzed along with the histologic grade and status of estrogen receptor (ER), progesterone receptor (PR), and HER2 expression. Results: In this cohort of advanced breast cancer patients (stage 3-4), no statistically significant differences in lateralization were identified based on patient age, tumor stage, or frequency of ER or Her2 expression (Table). A predominance of PR positivity (p=0.14 chi square analysis) and amplifications in the ERBB2 (p=0.37) and RAD21 (p=0.08) genes were detected in right side tumors. Conclusions: Together with the prior study, trends in asymmetry based on genomic, pathologic, and immunohistologic differences have been detected in breast cancers, including an increased incidence of ERBB2 and RAD21 amplification in right-side breast tumors in this cohort. The predominance of lower PR positivity in the left breast tumors may be due to preferential hypermethylation, consistent with reports that it mediates biologic lateralization changes, downregulates PR expression, and alters amplification rates. Epigenetic methylation, may contribute to asymmetric breast cancer biology and have implications for therapeutic strategy. Further study is warranted.[Table: see text]

A hybrid forecasting model for ageing breast deformation during yoga practice

2021 ◽  
pp. 004051752110408
Author(s):  
Jie Zhou ◽  
Jianming Chen ◽  
Newman Lau ◽  
Qian Mao ◽  
Zidan Gong ◽  
...  
Keyword(s):  
Left Breast ◽  
Forecasting Model ◽  
Yoga Practice ◽  
Grey Relation Analysis ◽  
Senior Women ◽  
Hybrid Forecasting ◽  
Learning Machine ◽  
The Right ◽  
Grey Relation ◽  
Motion Amplitude

In this work, the deformation of bilateral breasts was investigated with an established hybrid model to predict the nipple movement specifically for senior women during yoga exercise. A motion capture system was used to collect the displacement of 10 markers on the breasts from 11 senior women (average age of 62) during yoga practice and then the data were analyzed by integrating the absolute grey relation analysis (AGRA) and extreme learning machine (ELM). The right and left breasts had the maximum motion amplitude in the horizontal direction but they were respectively featured with contraction and extension during yoga practice. AGRA showed that the nipple motion was highly associated with the vertical region above the nipple for the left breast but the parallel region along with the nipple for the right breast. The ELM model is able to predict the nipple movement within tolerable error (∼0.0037). This study lays a foundation for a better understanding of ageing breast kinematics during yoga poses with limited practical experiments. Besides, the accurate and efficient results can be used not only for yoga pose instruction but also for ergonomic sports bra design.

scholarly journals Primary breast lymphoma of childhood: a case report and review of literature

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Giulia A. Restivo ◽  
Marta Pillon ◽  
Lara Mussolin ◽  
Clara Mosa ◽  
Angela Guarina ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
Local Treatment ◽  
B Cell Lymphoma ◽  
Left Breast ◽  
Primary Breast Lymphoma ◽  
Therapeutic Approaches ◽  
Case Presentation ◽  
Breast Lymphoma ◽  
The Right

Abstract Background Primary breast lymphoma (PBL) is an extremely rare neoplasm in children; by definition, it manifests in the breast without evidence of lymphoma elsewhere, except ipsilateral axillary nodes. Case presentation We report a case of a 15-year-old girl diagnosed with diffuse large B-cell lymphoma (DLBCL) of the right breast: the patient received chemotherapy and rituximab, achieving complete remission. A literature review revealed other 11 cases of pediatric PBL; it mainly affects female adolescents and can involve right and left breast equally. Different histologic subtypes have been described, arising from both B-cell and T-cell. Therapeutic approaches were very different, from chemotherapy to local treatment with surgery and/or radiotherapy. Conclusions Our case is the first in which rituximab was administered, suggesting to be a promising therapy in B-cell PBL, as already demonstrated in pediatric B-cell lymphoma from other sites. Further investigations are needed to identify prognostic factors and establish the most effective treatment.

scholarly journals The breast necrosis caused by oral anticoagulant therapy

2020 ◽  
Vol 148 (5-6) ◽  
pp. 372-375
Author(s):  
Aleksandar Guzijan ◽  
Radoslav Gajanin ◽  
Bozana Babic ◽  
Vesna Gajanin ◽  
Bojan Jovanic
Keyword(s):  
Anticoagulant Therapy ◽  
Breast Tissue ◽  
Oral Anticoagulant Therapy ◽  
Pectoral Muscle ◽  
Left Breast ◽  
Limited Mobility ◽  
Small Vessels ◽  
The Right ◽  
Two Stages ◽  
First Time

Introduction. Described in 1943 for the first time, breast necrosis during anticoagulant therapy is only rarely encountered in clinical practice. The objective of the article is to describe a patient who underwent anticoagulant therapy and developed breast necrosis during it. Case outline. A 57-year-old female patient was admitted to hospital with pain in her left breast, which upon examination showed to be erythematous, swelled, and hard. She had started experiencing the symptoms a few days earlier, and denied having had a fever. Over the previous four weeks she had received anticoagulant treatment (acenocoumarol) as popliteal embolectomy prophylaxis. The breast was firm, edematous, of limited mobility, and with no pectoral muscle infiltration. The breast ultrasound showed a homogeneous mass, with no signs of fluid retention or suspicious lesions. Upon admission, the patient began receiving intravenous antibiotic treatment and underwent blood tests. The second day upon admission, the patient?s breast revealed a clearly demarcated area of necrotic skin. Surgical treatment was indicated. The surgery was performed in two stages, the first of which included a partial resection of the necrotic breast tissue, and the second simplex mastectomy. Histological analysis showed severe superficial necrosis, with underlying diffuse deep venous thrombosis and marked arteritis of medium and small vessels. Focal areas of extensive necrosis were found deep in the breast parenchyma. Conclusion. Considering that breast necrosis is extremely rare, it is usually not suspected initially. Learning about the patient?s undergoing anticoagulant therapy is of crucial importance for reaching the right diagnosis. Breast abscesses should also be ruled out. Surgery is the treatment of choice, as changes to the breast tissue are usually irreversible.

Classification of Breast Thermograms Using Statistical Moments and Entropy Features with Probabilistic Neural Networks

2020 ◽  
pp. 1328-1340
Author(s):  
Natarajan Sriraam ◽  
Leema Murali ◽  
Amoolya Girish ◽  
Manjunath Sirur ◽  
Sushmitha Srinivas ◽  
...  
Keyword(s):  
Probabilistic Neural Network ◽  
Wavelet Packet ◽  
Histogram Equalization ◽  
Developed Countries ◽  
Left Breast ◽  
Statistical Moments ◽  
Thermal Images ◽  
Life Threatening ◽  
The Right

Breast cancer is considered as one of the life-threatening disease among woman population in developing as well as developed countries. This specific study reports on classification of breast thermograms using probabilistic neural network (PNN) with four statistical moments features mean, standard deviation, skewness and kurtosis and two entropy features, Shannon entropy and Wavelet packet entropy. The CLAHE histogram equalization algorithm with uniform and Rayleigh distributions were considered for contrast enhancement of breast thermal images. The asymmetry detection was performed by applying bilateral ratio. A total of 95 test images (normal = 53, abnormal = 42) was considered. Simulation study shows that CLAHE -RD with wavelet entropy features confirms the existence of symmetry on the right and left breast thermal images. An overall classification accuracy of 92.5% was achieved using the proposed multifeatures with PNN classifier. The proposed technique thus confirms the suitability as a screening tool for asymmetry detection as well as classification of breast thermograms.

Service Portfolio Measurement

2011 ◽  
pp. 926-957
Author(s):  
Jan Vom Brocke
Keyword(s):  
Measurement System ◽  
Business Processes ◽  
Design Science ◽  
Service Oriented Architectures ◽  
Service Portfolio ◽  
Management Perspective ◽  
Service Oriented ◽  
The Right ◽  
Comprehensive Framework ◽  
Technological Opportunities

Service-oriented architectures offer promising means to flexibly organize business processes. At the same time, new challenges for management arise in order to realize these potentials. Given the technological opportunities, these challenges essentially lie in choosing the right mix of services on the basis of an appropriate infrastructure supporting value adding activities. In order to support this management perspective, a focus on service-oriented business processes is suggested in this article. Hence, a shift from technical aspects of designing service-oriented information systems to economic aspects of using them according to business needs is drawn. For this purpose, findings on the evaluation of financial performance of service-oriented business processes are presented in this paper. The objective is to develop a measurement system for decision support on the con-figuration of a company’s service portfolio reflecting specific economic conditions relevant in a certain situation. Following a design science approach, general principles of a measurement system are worked out and structured in a comprehensive framework. Then, the application of a corresponding system is presented with a practical study. Finally, perspectives on the specification and implementation of the system are sketched.

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