scholarly journals The Great Paradox of Science: Why Its Conclusions Can Be Relied Upon Even Though They Cannot Be Proven

2021 ◽  
Vol 89 (9) ◽  
pp. 899-900
Author(s):  
Philip L. Taylor
Keyword(s):  
Great Paradox

The great paradox: Responsibility without empowerment

1992 ◽  
Vol 35 (5) ◽  
pp. 55-58 ◽  
Author(s):  
Manuel Werner
Keyword(s):  
Great Paradox

scholarly journals Materiales e innovación en arquitectura sanitaria: cobre, barrera antibacteriana para espacios sanitarios = Materials and innovation in sanitary architecture: copper, antibacterial barrier for sanitary spaces

2017 ◽  
Vol 3 (3) ◽  
pp. 55 ◽  
Author(s):  
Paula Aillón García ◽  
Consuelo Acha Román ◽  
Julian Manuel Domínguez Fernández
Keyword(s):  
Health Services ◽  
Antibacterial Property ◽  
Healthcare Services ◽  
Antibacterial Coating ◽  
Life Threatening ◽  
Antibacterial Material ◽  
Reduced Costs ◽  
Specific Illness ◽  
Great Paradox

La inclusión del cobre como material antibacteriano en la arquitectura sanitaria ayuda a resolver la gran paradoja que existe en los servicios asistenciales; entrar a servicios de salud para sanarse de una enfermedad puntual y adquirir enfermedades de riesgo de muerte. Esta investigación demuestra la eficacia del cobre en formato laminar en vez de sólido, haciendo mediciones de
 con luminometría, abriendo un camino factible para el cobre como revestimiento antibacteriano y dotando de su propiedad antibacteriana superficial a costos reducidos, sin necesidad de cambios de mobiliario ni obrasAbstractThe inclusion of copper as an antibacterial material in health architecture helps to solve the great paradox that exists in healthcare services; enter health services to heal from a specific illness and acquire life-threatening diseases. This research demonstrates the effectiveness of copper in laminar format instead of solid, making measurements of ATP with luminometry, opening a feasible way for copper as an antibacterial coating and endowing its superficial antibacterial property at reduced costs, without the need for furniture changes or works.

The Great Paradox:

2021 ◽  
pp. 219-237
Author(s):  
Heiner Flassbeck
Keyword(s):  
Great Paradox

scholarly journals Targeting CREB in Cancer Therapy: A Key Candidate or One of Many? An Update

Cancers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3166
Author(s):  
Luigi Sapio ◽  
Alessia Salzillo ◽  
Angela Ragone ◽  
Michela Illiano ◽  
Annamaria Spina ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Intratumor Heterogeneity ◽  
Epigenetic Alterations ◽  
Accurate Analysis ◽  
Clinical Prognosis ◽  
Tumor Plasticity ◽  
Proliferation And Apoptosis ◽  
Element Binding Protein ◽  
Cyclic Amp Response Element ◽  
Great Paradox

Intratumor heterogeneity (ITH) is considered the major disorienting factor in cancer treatment. As a result of stochastic genetic and epigenetic alterations, the appearance of a branched evolutionary shape confers tumor plasticity, causing relapse and unfavorable clinical prognosis. The growing evidence in cancer discovery presents to us “the great paradox” consisting of countless potential targets constantly discovered and a small number of candidates being effective in human patients. Among these, cyclic-AMP response element-binding protein (CREB) has been proposed as proto-oncogene supporting tumor initiation, progression and metastasis. Overexpression and hyperactivation of CREB are frequently observed in cancer, whereas genetic and pharmacological CREB downregulation affects proliferation and apoptosis. Notably, the present review is designed to investigate the feasibility of targeting CREB in cancer therapy. In particular, starting with the latest CREB evidence in cancer pathophysiology, we evaluate the advancement state of CREB inhibitor design, including the histone lysine demethylases JMJD3/UTX inhibitor GSKJ4 that we newly identified as a promising CREB modulator in leukemia cells. Moreover, an accurate analysis of strengths and weaknesses is also conducted to figure out whether CREB can actually represent a therapeutic candidate or just one of the innumerable preclinical cancer targets.

Noise in the Intensive Care Nursery

2002 ◽  
Vol 21 (1) ◽  
pp. 35-41 ◽  
Author(s):  
Neil Kellman
Keyword(s):  
Intensive Care ◽  
Worth Living ◽  
Lawn Mower ◽  
Paradoxical Situation ◽  
Premature Babies ◽  
Intensive Care Nursery ◽  
Great Paradox

THE PARABLE OF THE GARDENThe problem of juxtaposing noise and premature babies brings to mind the paradoxical situation of my neighhbor’s garden. This garden is an oasis of visual calm, with evergreen bushes sculpted into flowing waves in the traditional Japanese landscape style which alternate serenely with the perfect miniature green seas of the lawn. However, the great paradox here is the noise made by the tools needed to create this tiny paradise. The gas lawn mower is a familiar evil, but the latest laborsaving invention—the leaf blower— makes life as a neighbor hardly worth living while it’s being used. It is the coexistence and contradiction of these opposites that provides the theme for this article on noise in the intensive care nursery.

Book Review: The Great Paradox

1960 ◽  
Vol 14 (4) ◽  
pp. 490-490
Author(s):  
James R. Sydnor
Keyword(s):  
Great Paradox

scholarly journals The epistemological structure of mobilities

2018 ◽  
Vol 25 (1) ◽  
pp. 54-67 ◽  
Author(s):  
Maximiliano E. Korstanje
Keyword(s):  
Political Legitimacy ◽  
Tourism Industry ◽  
Rite Of Passage ◽  
Commercial Activity ◽  
Social Scientists ◽  
Content Type ◽  
Tourist Destinations ◽  
French Tradition ◽  
Epistemological Structure ◽  
Great Paradox

Purpose This paper aims to revolve around two problems which, though imagined as different, can be addressed altogether. On one hand, the advance of terrorism as a major threat to the tourism industry, while – on the other – we discuss the ontological nature of tourism as a rite of passage, which is vital to keep the political legitimacy of officialdom. At the time, paradoxically, social scientists shrug off tourism as a naïve commercial activity, while the main tourist destinations are being attacked by jihadism. This suggests the disinterest of ones associates to the interests of others. Design/methodology/approach The author holds the thesis that tourism derives from ancient institutions, which illuminated in the growth of Occident and the formation of hospitality. Capitalism hides the importance of tourism as a mere trivialization as a bit-player. However, a closer look reminds precisely the opposite. The recent attacks perpetrated at main destinations reveal tourism as an exemplary (symbolic) center of the West, a source of authority and power for the existing hierarchal order. Findings The issue captivates the attention of scholars, officials and policymakers, and at the same time, epistemologists of tourism receive a fresh novel debate regarding the origins of tourism. Originality/value It is a great paradox that tourism would be selected as a target for jihadism but at the same time a naïve activity for social scientists or at the least by the French tradition. Despite the partisan criticism exerted on tourism as an alienatory force, this work showed two important aspects, which merits to be discussed. At a closer look, tourism should be understood as “a rite of passage” whose function associates to the revitalization of those glitches happened during the cycles of production. Second, and most important, tourism accommodates those frustrations to prevent acts of separatism or the rise of extreme conflict among classes.

scholarly journals Sleeping for Two: The Great Paradox of Sleep in Pregnancy

2015 ◽  
Vol 11 (06) ◽  
pp. 593-594 ◽  
Author(s):  
Christine H.J. Won
Keyword(s):  
In Pregnancy ◽  
Great Paradox
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