SU-F-J-139: Amplitude of Low Frequency Fluctuation(ALFF) and Regional Homogeneity (ReHo) Study of the Respiration Motion Control Byhypnosis

2016 ◽  
Vol 43 (6Part10) ◽  
pp. 3439-3439 ◽  
Author(s):  
Y Liu ◽  
R Li ◽  
Y Xie
Keyword(s):  
Motion Control ◽  
Low Frequency ◽  
Regional Homogeneity ◽  
Frequency Fluctuation ◽  
Respiration Motion

scholarly journals Effects of the DRD4 −521 C/T SNP on Local Neural Activity and Functional Connectivity in Children With ADHD

2022 ◽  
Vol 12 ◽  
Author(s):  
Huan Zhang ◽  
Binrang Yang ◽  
Gang Peng ◽  
Linlin Zhang ◽  
Diangang Fang
Keyword(s):  
Functional Connectivity ◽  
Brain Function ◽  
Rating Scale ◽  
Low Frequency ◽  
Regional Homogeneity ◽  
Frequency Fluctuation ◽  
Behavioral Performance ◽  
Superior Frontal Gyrus ◽  
Middle Occipital Gyrus ◽  
The Right

Objective: The present study aimed to investigate the effects of the dopamine receptor D4 (DRD4) −521 C/T single-nucleotide polymorphism on brain function among children with attention deficit hyperactivity disorder (ADHD) and to evaluate whether brain function is associated with behavioral performance among this demographic.Methods: Using regional homogeneity, fractional amplitude low-frequency fluctuation, and functional connectivity as measurement indices, we compared differences in resting-state brain function between 34 boys with ADHD in the TT homozygous group and 37 boys with ADHD in the C-allele carrier group. The Conners' Parent Rating Scale, the SNAP-IV Rating Scale, the Stroop Color Word Test, the go/no-go task, the n-back task, and the working memory index within the Wechsler Intelligence Scale for Children-Fourth Edition were selected as comparative indicators in order to test effects on behavioral performance.Results: We found that TT homozygotes had low behavioral performance as compared with C-allele carriers. The regional homogeneity for TT homozygotes decreased in the right middle occipital gyrus and increased in the right superior frontal gyrus as compared with C-allele carriers. In addition, the right middle occipital gyrus and the right superior frontal gyrus were used as the seeds of functional connectivity, and we found that the functional connectivity between the right middle occipital gyrus and the right cerebellum decreased, as did the functional connectivity between the right superior frontal gyrus and the angular gyrus. No statistically significant differences were observed in the respective brain regions when comparing the fractional amplitudes for low-frequency fluctuation between the two groups. Correlation analyses demonstrated that the fractional amplitude low-frequency fluctuation in the precentral gyrus for TT homozygotes were statistically significantly correlated with working memory.Conclusions: We found differing effects of DRD4 −521 C/T polymorphisms on brain function among boys with ADHD. These findings promote our understanding of the genetic basis for neurobiological differences observed among children with ADHD, but they must be confirmed in larger samples.

scholarly journals Altered patterns of fractional amplitude of low-frequency fluctuation and regional homogeneity in abstinent methamphetamine-dependent users

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
An Xie ◽  
Qiuxia Wu ◽  
Winson Fu Zun Yang ◽  
Chang Qi ◽  
Yanhui Liao ◽  
...  
Keyword(s):  
Resting State ◽  
Brain Activity ◽  
Inferior Frontal Gyrus ◽  
Low Frequency ◽  
Regional Homogeneity ◽  
Anterior Cingulate ◽  
Frequency Fluctuation ◽  
Early Recovery ◽  
Left Inferior Frontal Gyrus ◽  
The Right

AbstractMethamphetamine (MA) could induce functional and structural brain alterations in dependent subjects. However, few studies have investigated resting-state activity in methamphetamine-dependent subjects (MADs). We aimed to investigate alterations of brain activity during resting-state in MADs using fractional amplitude of low-frequency fluctuation (fALFF) and regional homogeneity (ReHo). We analyzed fALFF and ReHo between MADs (n = 70) and healthy controls (HCs) (n = 84) and performed regression analysis using MA use variables. Compared to HCs, abstinent MADs showed increased fALFF and ReHo values in the bilateral striatum, decreased fALFF in the left inferior frontal gyrus, and decreased ReHo in the bilateral anterior cingulate cortex, sensorimotor cortex, and left precuneus. We also observed the fALFF values of bilateral striatum were positively correlated with the age of first MA use, and negatively correlated with the duration of MA use. The fALFF value of right striatum was also positively correlated with the duration of abstinence. The alterations of spontaneous cerebral activity in abstinent MADs may help us probe into the neurological pathophysiology underlying MA-related dysfunction and recovery. Since MADs with higher fALFF in the right striatum had shorter MA use and longer abstinence, the increased fALFF in the right striatum might implicate early recovery during abstinence.

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