Fiducial marker and marker-less soft-tissue detection using fast MV fluoroscopy on a new generation EPID: Investigating the influence of pulsing artifacts and artifact suppression techniques

2014 ◽  
Vol 41 (10) ◽  
pp. 101911 ◽  
Author(s):  
Kenneth Poels ◽  
Dirk Verellen ◽  
Iwein Van de Vondel ◽  
Rafik El Mazghari ◽  
Tom Depuydt ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Fiducial Marker ◽  
Artifact Suppression ◽  
New Generation

scholarly journals Intraoperative marking of the tumour resection surface for improved radiation therapy planning in head and neck cancer: preclinical evaluation of a novel liquid fiducial marker

2020 ◽  
pp. 20200290
Author(s):  
David Steybe ◽  
Maximilian Frederik Russe ◽  
Ute Ludwig ◽  
Tanja Sprave ◽  
Kirstin Vach ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Soft Tissue ◽  
Oral Cancer ◽  
Intensity Modulated Radiation Therapy ◽  
Fiducial Marker ◽  
Tumour Resection ◽  
Therapy Planning ◽  
Preclinical Evaluation ◽  
Oral Cancer Patients ◽  
Signal Intensities

Objective To evaluate a novel liquid fiducial marker for intraoperative marking of the tumour resection surface in oral cancer patients to facilitate precise postoperative delineation of the interface between the tumour resection border and reconstructed tissue for intensity-modulated radiation therapy. Methods A total of 200 markers were created by injecting the volumes of 10 µl, 20 µl, 30 µl, 40 µl and 50 µl of a liquid marker composed of sucrose acetoisobutyrate (SAIB) and iodinated sucrose acetoisobutyrate (x-SAIB) into the soft tissue of porcine mandible segments. Visibility of the resulting markers was quantified by threshold-based segmentation of the marker volume in CT- and CBCT imaging and by a comparison of signal intensities in MRI. Results Even the lowest volume of SAIB-/x-SAIB investigated (10 µl) resulted in a higher visibility (CTSoft tissue: 88.18 ± 13.23 µl; CTBone: 49.55 ± 7.62 µl; CBCT: 54.65 ± 12.58 µl) than observed with the incorporation of titanium ligature clips (CTSoft tissue: 50.15 ± 7.50 mm3; CTBone: 23.90 ± 3.39 mm3; CBCT: 33.80 ± 9.20 mm3). Markers created by the injection of 10 µl and 20 µl could reliably be delineated from markers created by the injection of higher volumes. Conclusion SAIB/x-SAIB, which has recently become available as a Conformité Européenne (CE)-marked fiducial marker, provides an option for fast and reliable production of markers with excellent visibility in imaging modalities used in oral cancer radiation therapy (RT) planning routine.

scholarly journals Evaluation of computed tomography settings in the context of visualization and discrimination of low dose injections of a novel liquid soft tissue fiducial marker in head and neck imaging

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
David Steybe ◽  
Philipp Poxleitner ◽  
Pit Jacob Voss ◽  
Marc Christian Metzger ◽  
Rainer Schmelzeisen ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Head And Neck ◽  
Low Dose ◽  
Tumor Resection ◽  
Fiducial Marker ◽  
Fiducial Markers ◽  
Clinical Routine ◽  
Injection Volume ◽  
Tumor Bed ◽  
Oral Soft Tissue

Abstract Background Intraoperative incorporation of radiopaque fiducial markers at the tumor resection surface can provide useful assistance in identifying the tumor bed in postoperative imaging for RT planning and radiological follow-up. Besides titanium clips, iodine containing injectable liquid fiducial markers represent an option that has emerged more recently for this purpose. In this study, marking oral soft tissue resection surfaces, applying low dose injections of a novel Conformité Européenne (CE)-marked liquid fiducial marker based on sucrose acetoisobutyrate (SAIB) and iodinated SAIB (x-SAIB) was investigated. Methods Visibility and discriminability of low dose injections of SAIB/x-SAIB (10 µl, 20 µl, 30 µl) were systematically studied at different kV settings used in clinical routine in an ex-vivo porcine mandible model. Transferability of the preclinical results into the clinical setting and applicability of DE-CT were investigated in initial patients. Results Markers created by injection volumes as low as 10 µl were visible in CT imaging at all kV settings applied in clinical routine (70–120 kV). An injection volume of 30 µl allowed differentiation from an injection volume of 10 µl. In a total of 118 injections performed in two head and neck cancer patients, markers were clearly visible in 83% and 86% of injections. DE-CT allowed for differentiation between SAIB/x-SAIB markers and other hyperdense structures. Conclusions Injection of low doses of SAIB/x-SAIB was found to be a feasible approach to mark oral soft tissue resection surfaces, with injection volumes as low as 10 µl found to be visible at all kV settings applied in clinical routine. With the application of SAIB/x-SAIB reported for tumors of different organs already, mostly applying relatively large volumes for IGRT, this study adds information on the applicability of low dose injections to facilitate identification of the tumor bed in postoperative CT and on performance of the marker at different kV settings used in clinical routine.

Assessment of cone beam CT registration for prostate radiation therapy: Fiducial marker and soft tissue methods

2014 ◽  
Vol 59 (1) ◽  
pp. 91-98 ◽  
Author(s):  
Timothy Deegan ◽  
Rebecca Owen ◽  
Tanya Holt ◽  
Andrew Fielding ◽  
Jennifer Biggs ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Soft Tissue ◽  
Cone Beam Ct ◽  
Fiducial Marker ◽  
Cone Beam

SU-E-J-24: Can Fiducial Marker-Based Setup Using ExacTrac Be An Alternative to Soft Tissue-Based Setup Using Cone-Beam CT for Prostate IMRT?

2015 ◽  
Vol 42 (6) ◽  
pp. 3268-3269
Author(s):  
S Tanabe ◽  
S Utsunomiya ◽  
E Abe ◽  
H Satou ◽  
H Sakai ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Cone Beam Ct ◽  
Fiducial Marker ◽  
Cone Beam ◽  
J 24
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