TH-C-BRD-08: Reducing the Effect of Respiratory Motion On the Delivered Dose in Proton Therapy Through Proper Field Angle Selection

2014 ◽  
Vol 41 (6Part32) ◽  
pp. 552-552
Author(s):  
J Matney ◽  
P Park ◽  
L Court ◽  
X Zhu ◽  
H Li ◽  
...  
Keyword(s):  
Proton Therapy ◽  
Respiratory Motion ◽  
Delivered Dose ◽  
Proper Field

SU-E-T-394: Comparison of Planned Dose Distribution Vs. Delivered Dose Distribution for Both IMRT and Proton Therapy Using Weekly Repeat 4DCT Data Sets

2012 ◽  
Vol 39 (6Part16) ◽  
pp. 3795-3795
Author(s):  
Y Chen ◽  
L Zhang ◽  
L Court ◽  
Z Liao ◽  
X Zhu ◽  
...  
Keyword(s):  
Proton Therapy ◽  
Dose Distribution ◽  
Data Sets ◽  
Delivered Dose

SU-E-T-452: Impact of Respiratory Motion On Robustly-Optimized Intensity-Modulated Proton Therapy to Treat Lung Cancers

2014 ◽  
Vol 41 (6Part18) ◽  
pp. 330-330
Author(s):  
W Liu ◽  
Z Liao ◽  
S Schild ◽  
P Park ◽  
H Li ◽  
...  
Keyword(s):  
Proton Therapy ◽  
Respiratory Motion ◽  
Lung Cancers ◽  
Intensity Modulated Proton Therapy ◽  
Intensity Modulated

scholarly journals Impact of respiratory motion on variable relative biological effectiveness in 4D-dose distributions of proton therapy

2017 ◽  
Vol 56 (11) ◽  
pp. 1420-1427 ◽  
Author(s):  
Silke Ulrich ◽  
Hans-Peter Wieser ◽  
Wenhua Cao ◽  
Radhe Mohan ◽  
Mark Bangert
Keyword(s):  
Proton Therapy ◽  
Respiratory Motion ◽  
Relative Biological Effectiveness ◽  
Dose Distributions ◽  
Biological Effectiveness

scholarly journals CBCT-Based Adaptive Assessment Workflow for Intensity Modulated Proton Therapy for Head and Neck Cancer

2021 ◽  
Author(s):  
Mariluz De Ornelas ◽  
Yihang Xu ◽  
Kyle Padgett ◽  
Ryder M. Schmidt ◽  
Michael Butkus ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Head And Neck ◽  
Proton Therapy ◽  
Case Scenario ◽  
Worst Case ◽  
Intensity Modulated Proton Therapy ◽  
Intensity Modulated ◽  
Worst Case Scenario ◽  
Patient Setup ◽  
Delivered Dose

Abstract Purpose Anatomical changes and patient setup uncertainties during intensity modulated proton therapy (IMPT) of head and neck (HN) cancers demand frequent evaluation of delivered dose. This work investigated a cone-beam computed tomography (CBCT) and deformable image registration based therapy workflow to demonstrate the feasibility of proton dose calculation on synthetic computed tomography (sCT) for adaptive IMPT treatment of HN cancer. Materials and Methods Twenty-one patients with HN cancer were enrolled in this study, a retrospective institutional review board protocol. They had previously been treated with volumetric modulated arc therapy and had daily iterative CBCT. For each patient, robust optimization (RO) IMPT plans were generated using ±3 mm patient setup and ±3% proton range uncertainties. The sCTs were created and the weekly delivered dose was recalculated using an adaptive dose accumulation workflow in which the planning computed tomography (CT) was deformably registered to CBCTs and Hounsfield units transferred from the planning CT. Accumulated doses from ±3 mm/±3% RO-IMPT plans were evaluated using clinical dose-volume constraints for targets (clinical target volume, or CTV) and organs at risk. Results Evaluation of weekly recalculated dose on sCTs showed that most of the patient plans maintained target dose coverage. The primary CTV remained covered by the V95 > 95% (95% of the volume receiving more than 95% of the prescription dose) worst-case scenario for 84.5% of the weekly fractions. The oral cavity accumulated mean dose remained lower than the worst-case scenario for all patients. Parotid accumulated mean dose remained within the uncertainty bands for 18 of the 21 patients, and all were kept lower than RO-IMPT worst-case scenario for 88.7% and 84.5% for left and right parotids, respectively. Conclusion This study demonstrated that RO-IMPT plans account for most setup and anatomical uncertainties, except for large weight-loss changes that need to be tracked throughout the treatment course. We showed that sCTs could be a powerful decision tool for adaptation of these cases in order to reduce workload when using repeat CTs.

MO-D-108-09: Perturbation of Tissue Density Is An Important Metric to Be Considered When Planning for Respiratory Motion Management for Lung Proton Therapy

2013 ◽  
Vol 40 (6Part24) ◽  
pp. 397-398
Author(s):  
P Park ◽  
J Matlney ◽  
R Mohlan ◽  
X Zlhu ◽  
L Dong ◽  
...  
Keyword(s):  
Proton Therapy ◽  
Respiratory Motion ◽  
Motion Management ◽  
Tissue Density

scholarly journals Perturbation of water‐equivalent thickness as a surrogate for respiratory motion in proton therapy

2016 ◽  
Vol 17 (2) ◽  
pp. 368-378 ◽  
Author(s):  
Jason E. Matney ◽  
Peter C. Park ◽  
Heng Li ◽  
Laurence E. Court ◽  
X. Ron Zhu ◽  
...  
Keyword(s):  
Proton Therapy ◽  
Respiratory Motion ◽  
Equivalent Thickness
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