SU-E-T-678: Normal Tissue Dose-Volume Constrains for Inverse Planning of Acoustic Neuroma Stereotactic Radiosurgery (SRS)

2013 ◽  
Vol 40 (6Part21) ◽  
pp. 362-362
Author(s):  
H Liu ◽  
D Andrews ◽  
M Werner-Wasik ◽  
Y Xiao ◽  
Y Yu ◽  
...  
Keyword(s):  
Stereotactic Radiosurgery ◽  
Acoustic Neuroma ◽  
Normal Tissue ◽  
Inverse Planning ◽  
Tissue Dose ◽  
Dose Volume

scholarly journals Respiratory motion during 90Yttrium PET contributes to underestimation of tumor dose and overestimation of normal liver tissue dose

2017 ◽  
Vol 59 (2) ◽  
pp. 132-139
Author(s):  
Line Ausland ◽  
Mona-Elisabeth Revheim ◽  
Arne Skretting ◽  
Caroline Stokke
Keyword(s):  
Normal Tissue ◽  
Respiratory Motion ◽  
Tumor Volume ◽  
Quantitative Imaging ◽  
Normal Liver ◽  
Dose Volume Histogram ◽  
Heterogeneous Distribution ◽  
Tissue Dose ◽  
Dose Volume ◽  
Yttrium 90

Background Yttrium-90 dosimetry after radioembolization is reliant on accurate quantitative imaging of the microsphere deposition. Previous studies have focused on the correction of geometrical resolution effects. Purpose To uncover additional effects of respiratory motion. Material and Methods Mathematical models describing spherical tumors were formed and two blurring effects, limited geometrical resolution and respiratory motion, were simulated. The virtual images were used as basis for dose volume histogram estimations by convolving the radioactivity representations with a dose point kernel. Results For respiratory motion only, the largest errors were found for the smallest tumors and/or tumors with heterogeneous distribution of yttrium-90 microspheres. The deviations in max dose and dose to 25% and 50% of the tumor volume were estimated at 20–40%, 10–30%, and 0–30%, respectively. Additional blurring from geometrical resolution increased the errors to 55–75%, 50–60%, and 25–60%, respectively. Conclusion Respiratory motion contributes to underestimation of tumor dose and overestimation of normal tissue dose.

scholarly journals EP-1908 A Guide For Predicting Normal Tissue Dose in Stereotactic Radiosurgery

2019 ◽  
Vol 133 ◽  
pp. S1037
Author(s):  
D. Cummins ◽  
C. Skourou ◽  
S. O'Sullivan ◽  
P. Davenport ◽  
D. Fitzpatrick ◽  
...  
Keyword(s):  
Stereotactic Radiosurgery ◽  
Normal Tissue ◽  
Tissue Dose

35 Tumor and normal tissue dose-volume histograms in interstitial head and neck brachytherapy

1998 ◽  
Vol 47 ◽  
pp. S9 ◽  
Author(s):  
S. Guard ◽  
D. Peillert ◽  
P. Aleni ◽  
M. Lapeyre ◽  
S. Holfstetter ◽  
...  
Keyword(s):  
Head And Neck ◽  
Normal Tissue ◽  
Dose Volume Histograms ◽  
Tissue Dose ◽  
Dose Volume

Dose-Volume Analysis of Radiation-Induced Optic Neuropathy After Single-Fraction Stereotactic Radiosurgery

Neurosurgery ◽  
2014 ◽  
Vol 75 (4) ◽  
pp. 456-460 ◽  
Author(s):  
Bruce E. Pollock ◽  
Michael J. Link ◽  
Jacqueline A. Leavitt ◽  
Scott L. Stafford
Keyword(s):  
Stereotactic Radiosurgery ◽  
Optic Neuropathy ◽  
Normal Tissue ◽  
Normal Tissue Complication Probability ◽  
Maximum Point ◽  
Single Fraction ◽  
Dose Volume ◽  
Before And After ◽  
Radiation Induced ◽  
Radiation Treatments

Abstract BACKGROUND: The risk of radiation-induced optic neuropathy (RION) is the primary limitation of single-fraction stereotactic radiosurgery (SRS) for many patients with parasellar lesions. OBJECTIVE: To define the normal tissue complication probability of the anterior visual pathways (AVPs) after single-fraction SRS. METHODS: Retrospective review comparing visual function before and after SRS in 133 patients (266 sides) with pituitary adenomas having SRS between October 2007 and July 2012. Patients with prior radiation therapy or SRS were excluded. The median follow-up after SRS was 32 months. RESULTS: The median maximum point dose to the AVP was 9.2 Gy (interquartile range [IQR], 6.9-10.8). One hundred seventy-four sides (65%) received >8 Gy: the median 8-Gy volume was 15.8 mm3 (IQR, 3.7-36.2). Ninety-four sides (35%) received >10 Gy; the median 10-Gy volume was 1.6 mm3 (IQR, 0.5-5.3). Twenty-nine sides (11%) received >12 Gy; the median 12-Gy volume was 0.1 mm3 (IQR, 0.1-0.6). No patient had a RION after SRS. The chances of developing a RION at the 8-Gy, 10-Gy, and 12-Gy volumes (95% confidence interval) in this series were 0% to 2.6%, 0% to 4.7%, and 0% to 13.9%, respectively. CONCLUSION: The AVP in patients without prior radiation treatments can safely receive radiation doses up to 12 Gy with a low risk of RION. Although additional studies are needed to better delineate the normal tissue complication probability of the AVP, adherence to the AVP radiation tolerance guidelines developed 20 years ago (8 Gy) limits the applicability and potentially the effectiveness of single-fraction SRS for patients with lesions in the parasellar region.

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