Stereotactic radiosurgery and hypofractionated stereotactic radiotherapy: Normal tissue dose constraints of the central nervous system

2011 ◽  
Vol 37 (7) ◽  
pp. 567-578 ◽  
Author(s):  
Michael T. Milano ◽  
Kenneth Y. Usuki ◽  
Kevin A. Walter ◽  
Douglas Clark ◽  
Michael C. Schell
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Stereotactic Radiosurgery ◽  
Stereotactic Radiotherapy ◽  
Normal Tissue ◽  
Hypofractionated Stereotactic Radiotherapy ◽  
Tissue Dose ◽  
The Central Nervous System ◽  
Dose Constraints

Milestones in stereotactic radiosurgery for the central nervous system

2019 ◽  
Vol 59 ◽  
pp. 12-19 ◽  
Author(s):  
Stefan Mitrasinovic ◽  
Michael Zhang ◽  
Geoff Appelboom ◽  
Eric Sussman ◽  
Justin M. Moore ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Stereotactic Radiosurgery ◽  
The Central Nervous System

Normal Tissue Dose Constraints for Multiple Lung Stereotactic Radiotherapy Treatments

2018 ◽  
Vol 30 (7) ◽  
pp. 455 ◽  
Author(s):  
Q. Ghafoor ◽  
B. Allos ◽  
R. Stevenson ◽  
S. Watkins ◽  
S. Yahya ◽  
...  
Keyword(s):  
Stereotactic Radiotherapy ◽  
Normal Tissue ◽  
Tissue Dose ◽  
Dose Constraints

scholarly journals Normal Tissue Dose Constraints for Multiple Lung Stereotactic Radiotherapy Treatments

2020 ◽  
pp. 1-4
Author(s):  
Beshar Allos ◽  
H. Howard ◽  
Beshar Allos ◽  
D. Stange ◽  
J. Bhogal ◽  
...  
Keyword(s):  
Stereotactic Radiotherapy ◽  
Normal Tissue ◽  
Current Evidence ◽  
Normal Lung ◽  
Lung Lesions ◽  
Multiple Lesions ◽  
Tissue Dose ◽  
Dose Constraints

Introduction: The role and use of stereotactic radiotherapy (SABR) is evolving rapidly. A key article by Hanna et al. (2017) provides an excellent overview of current evidence and suggestion of sensible dose constraints. Given the topical nature of this discussion we present a short retrospective analysis of treating multiple lung SABR patients at our centre. Method: We retrospectively analysed toxicity, both early (within 3 months of SABR) and late, and normal tissue dose constraints on all patients who had multiple lung lesions treated with SABR (using volumetric modulated arc therapy (VMAT) technique) at our tertiary centre over a 25-month period from April 2016 until May 2018. Results: We have treated 78 lung lesions in 37 patients with a combination of synchronous lung cancer primaries and lung metastases diagnoses. Median follow-up was 9 months. Almost all patients received treatment on the same day for multiple lesions. We report no grade 3 toxicities in any patient nor any unexpected side effects. 5 patients (14.7%) developed grade 2 pneumonitis. In all 5 patients, lung V12.5 was >20% (range 20.8-32.2%), yet only 1 patient exceeded acceptable lung V20 constraints. Regarding long-term toxicity, 66.6% of patients reported no treatment-related effects. Of 9 patients with long-term toxicity, 8 exceeded V12.5 constraint of <15%, indeed of these 5 were >20%. Lung V20 levels were acceptable for the majority of these. Local control of treated lesions at median follow-up in all comers was 86.2%. Discussion: Our findings show that multiple lung SABR is tolerable, safe with minimal long-term toxicity and acceptable early toxicity. Defining normal lung V12.5 of <15% (optimal) and <20% (acceptable) will significantly reduce the risk of pneumonitis and longer-term toxicity, proving itself more predictive than lung V20 levels for toxicity. Additionally, treating multiple lesions concurrently appears to bare no extra risk to patients.

scholarly journals UK Consensus on Normal Tissue Dose Constraints for Stereotactic Radiotherapy

2018 ◽  
Vol 30 (1) ◽  
pp. 5-14 ◽  
Author(s):  
G.G. Hanna ◽  
L. Murray ◽  
R. Patel ◽  
S. Jain ◽  
K.L. Aitken ◽  
...  
Keyword(s):  
Stereotactic Radiotherapy ◽  
Normal Tissue ◽  
Tissue Dose ◽  
Dose Constraints

UK Consensus on Normal Tissue Dose Constraints for Stereotactic Radiotherapy: Reply to Ghafoor et al.

2018 ◽  
Vol 30 (7) ◽  
pp. 456 ◽  
Author(s):  
G.G. Hanna ◽  
F. McDonald ◽  
L. Murray ◽  
S. Harrow ◽  
D. Landau ◽  
...  
Keyword(s):  
Stereotactic Radiotherapy ◽  
Normal Tissue ◽  
Tissue Dose ◽  
Dose Constraints
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