SU-E-J-164: Photodynamic Activity of Alternative Photosensitizers with Mamma Carcinoma Cell Lines (MCF-7)

2013 ◽  
Vol 40 (6Part9) ◽  
pp. 189-189
Author(s):  
G Dheva Shantha Kumari
Keyword(s):  
Cell Lines ◽  
Carcinoma Cell ◽  
Mamma Carcinoma ◽  
Carcinoma Cell Lines ◽  
Photodynamic Activity ◽  
Mcf 7

Anticancer Activity of Some Bisbenzimidazoles

2011 ◽  
Vol 66 (9-10) ◽  
pp. 465-470 ◽  
Author(s):  
İlhan Işıkdağ ◽  
Yusuf Özkay ◽  
Zerrin İncesu ◽  
Gülşen Akalın
Keyword(s):  
Anticancer Activity ◽  
Cell Lines ◽  
Topoisomerase I ◽  
Carcinoma Cell ◽  
Dna Topoisomerase ◽  
Carcinoma Cell Lines ◽  
Activity Screening ◽  
Breast Carcinoma Cell Lines ◽  
Ht 29 ◽  
Mcf 7

The discovery of DNA topoisomerases has added a new dimension to the study of anticancer drugs. Bisbenzimidazole derivatives are important compounds known as DNA topoisomerase I inhibitors. In the present study, some symmetrical bisbenzimidazole derivatives were synthesized and investigated for their anticancer activity. Anticancer activity screening was applied on HT-29 (colon carcinoma) and MCF-7 (breast carcinoma) cell lines by investigation of cytotoxicity, analysis of DNA synthesis, and DNA fragmentation assays. One of the seven compounds tested showed signifi cant cytotoxicity in both cell lines and caused DNA degradation in the HT-29 cell line.

scholarly journals PO-1087 The interaction between miR-221 overexpression and radiosensitivity in mamma carcinoma cell lines

2019 ◽  
Vol 133 ◽  
pp. S603-S604
Author(s):  
E. Hirmer ◽  
R. Kell ◽  
S. Winkler ◽  
K. Winkler ◽  
L. Mutschelknaus ◽  
...  
Keyword(s):  
Cell Lines ◽  
Carcinoma Cell ◽  
Mamma Carcinoma ◽  
Carcinoma Cell Lines

Cationic Phosphorus Dendrimer Enhances Photodynamic Activity of Rose Bengal against Basal Cell Carcinoma Cell Lines

2017 ◽  
Vol 14 (5) ◽  
pp. 1821-1830 ◽  
Author(s):  
Monika Dabrzalska ◽  
Anna Janaszewska ◽  
Maria Zablocka ◽  
Serge Mignani ◽  
Jean Pierre Majoral ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cell Lines ◽  
Basal Cell ◽  
Rose Bengal ◽  
Carcinoma Cell ◽  
Carcinoma Cell Lines ◽  
Photodynamic Activity

Antiproliferative activity of lignans against the breast carcinoma cell lines MCF 7 and BT 20

2011 ◽  
Vol 285 (4) ◽  
pp. 1145-1151 ◽  
Author(s):  
Sibylle Abarzua ◽  
Tatsuo Serikawa ◽  
Marlen Szewczyk ◽  
Dagmar-Ulrike Richter ◽  
Birgit Piechulla ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Cell Lines ◽  
Antiproliferative Activity ◽  
Carcinoma Cell ◽  
Carcinoma Cell Lines ◽  
Breast Carcinoma Cell Lines ◽  
Mcf 7

scholarly journals A RXR Ligand 6-OH-11-O-Hydroxyphenanthrene with Antitumour Properties Enhances (−)-Epigallocatechin-3-gallate Activity in Three Human Breast Carcinoma Cell Lines

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Fulvia Farabegoli ◽  
Marzia Govoni ◽  
Carmen Ciavarella ◽  
Marina Orlandi ◽  
Alessio Papi
Keyword(s):  
Breast Carcinoma ◽  
Cell Lines ◽  
Carcinoma Cell ◽  
Chemotherapeutic Agents ◽  
Laminin Receptor ◽  
Molecular Characteristics ◽  
Carcinoma Cell Lines ◽  
X Receptors ◽  
Breast Carcinoma Cell Lines ◽  
Mcf 7

(−)-Epigallocatechin-3-gallate (EGCG) and chemotherapeutic agents cotreatment can improve cytotoxicity against cancer cells. We showed that EGCG and the rexinoid 6-OH-11-O-hydroxyphenanthrene (IIF), given together, were cytotoxic toward MCF-7, MCF-7TAM, and MDA-MB-231, three breast carcinoma cell lines showing different molecular characteristics. Cell growth arrest and apoptosis were greater after EGCG and IIF cotreatment than after individual administration. Cytotoxicity was related to upregulation of 67-kDa laminin receptor (LR67), one of the principal molecular targets of EGCG, and activation of the nuclear retinoic X receptors (RXRs) pathway. Furthermore, the transcription factor Forkhead box O3 (Foxo3a), a protein able to trigger apoptosis through upregulation of genes necessary for cell death, was activated. EGCG and IIF cotreatment produced a significant nuclear import of Foxo3a from the cytoplasm in MCF-7, MCF-7TAM, and MDA-MB-231 cells. In MCF-7TAM cells only, Foxo3a nuclear localization was associated with p473AKT downregulation. For the first time we showed that when EGCG and IIF, two harmless molecules, were given together, they might increase cytotoxicity in three breast carcinoma cell lines, two of them being representative of poorly responsive breast carcinoma types.

scholarly journals Cytotoxic Effects of Thiazolo[3,2-C]Pyrimidines Against Mcf-7 And Hepg2/C3a Carcinoma Cell Lines

2018 ◽  
Vol 2 (46) ◽  
pp. 237-246 ◽  
Author(s):  
Arzu Birinci Yıldırım ◽  
Esra Mutlu ◽  
Muhammet Yıldırım
Keyword(s):  
Cell Lines ◽  
Carcinoma Cell ◽  
Cytotoxic Effects ◽  
Carcinoma Cell Lines ◽  
Mcf 7
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