TU-A-BRA-04: Real-Time Metabolic Image-Guidance to Aid Intraoperative Radiation Therapy: Pilot Results in a Small-Animal Model

2012 ◽  
Vol 39 (6Part22) ◽  
pp. 3888-3888
Author(s):  
C Carpenter ◽  
C Sun ◽  
G Pratx ◽  
K Chen ◽  
L Senadheera ◽  
...  
Keyword(s):  
Animal Model ◽  
Radiation Therapy ◽  
Real Time ◽  
Image Guidance ◽  
Small Animal ◽  
Intraoperative Radiation Therapy ◽  
Small Animal Model ◽  
Intraoperative Radiation

Closed-chest small animal model to study myocardial infarction in an MRI environment in real time

2014 ◽  
Vol 31 (1) ◽  
pp. 115-121 ◽  
Author(s):  
Darach O h-Ici ◽  
Sarah Jeuthe ◽  
Thore Dietrich ◽  
Felix Berger ◽  
Titus Kuehne ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Animal Model ◽  
Real Time ◽  
Small Animal ◽  
Small Animal Model ◽  
Closed Chest ◽  
Mri Environment

scholarly journals Cardiac Magnetic Resonance for Early Detection of Radiation Therapy-Induced Cardiotoxicity in a Small Animal Model

2021 ◽  
Vol 3 (1) ◽  
pp. 113-130
Author(s):  
El-Sayed H. Ibrahim ◽  
Dhiraj Baruah ◽  
Pierre Croisille ◽  
Jadranka Stojanovska ◽  
Jason C. Rubenstein ◽  
...  
Keyword(s):  
Animal Model ◽  
Radiation Therapy ◽  
Cardiac Magnetic Resonance ◽  
Magnetic Resonance ◽  
Early Detection ◽  
Small Animal ◽  
Small Animal Model

Vascular and Nerval Damage After Intraoperative Radiation Therapy of the Liver Hilum in a Large Animal Model

2013 ◽  
Vol 27 (3) ◽  
pp. 163-168 ◽  
Author(s):  
Benjamin Juntermanns ◽  
Florian Grabellus ◽  
Hongwei Zhang ◽  
Sonia Radunz ◽  
Johannes Bernheim ◽  
...  
Keyword(s):  
Animal Model ◽  
Radiation Therapy ◽  
Intraoperative Radiation Therapy ◽  
Large Animal Model ◽  
Large Animal ◽  
Intraoperative Radiation

scholarly journals Real-time bladder volume monitoring by the application of a new implantable bladder volume sensor for a small animal model

2011 ◽  
Vol 27 (4) ◽  
pp. 132-137 ◽  
Author(s):  
Dong Sup Lee ◽  
Su Jin Kim ◽  
Dong Wan Sohn ◽  
Bumkyoo Choi ◽  
Moon Kyu Lee ◽  
...  
Keyword(s):  
Animal Model ◽  
Real Time ◽  
Small Animal ◽  
Bladder Volume ◽  
Small Animal Model ◽  
Volume Sensor

scholarly journals Changes in peripheral immune cells after intraoperative radiation therapy in low-risk breast cancer

2020 ◽  
Vol 62 (1) ◽  
pp. 110-118
Author(s):  
Isabel Linares-Galiana ◽  
Miguel Angel Berenguer-Frances ◽  
Rut Cañas-Cortés ◽  
Monica Pujol-Canadell ◽  
Silvia Comas-Antón ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Single Dose ◽  
Cancer Patients ◽  
Antitumor Immunity ◽  
Low Risk ◽  
Intraoperative Radiation Therapy ◽  
Breast Cancer Patients ◽  
Intraoperative Radiation ◽  
Risk Breast Cancer

Abstract A detailed understanding of the interactions and the best dose-fractionation scheme of radiation to maximize antitumor immunity have not been fully established. In this study, the effect on the host immune system of a single dose of 20 Gy through intraoperative radiation therapy (IORT) on the surgical bed in low-risk breast cancer patients undergoing conserving breast cancer has been assessed. Peripheral blood samples from 13 patients were collected preoperatively and at 48 h and 3 and 10 weeks after the administration of radiation. We performed a flow cytometry analysis for lymphocyte subpopulations, natural killer cells (NK), regulatory T cells (Treg) and myeloid-derived suppressor cells (MDSCs). We observed that the subpopulation of NK CD56+high CD16+ increased significantly at 3 weeks after IORT (0.30–0.42%, P < 0.001), while no changes were found in immunosuppressive profile, CD4+CD25+Foxp3+Helios+ Treg cells, granulocytic MDSCs (G-MDSCs) and monocytic MDSCs (Mo-MDSCs). A single dose of IORT may be an effective approach to improve antitumor immunity based on the increase in NK cells and the non-stimulation of immunosuppressive cells involved in immune escape. These findings support future combinations of IORT with immunotherapy, if they are confirmed in a large cohort of breast cancer patients.

scholarly journals Rat model of smoke inhalation-induced acute lung injury

2021 ◽  
Vol 8 (1) ◽  
pp. e000879
Author(s):  
Premila Devi Leiphrakpam ◽  
Hannah R Weber ◽  
Tobi Ogun ◽  
Keely L Buesing
Keyword(s):  
Animal Model ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Caspase 3 ◽  
Small Animal ◽  
Therapeutic Options ◽  
Smoke Inhalation ◽  
Small Animal Model ◽  
Injury Score ◽  
Confounding Variables

BackgroundAcute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a lethal disease with limited therapeutic options and an unacceptably high mortality rate. Understanding the complex pathophysiological processes involved in the development of ALI/ARDS is critical for developing novel therapeutic strategies. Smoke inhalation (SI) injury is the leading cause of morbidity and mortality in patients with burn-associated ALI/ARDS; however, to our knowledge few reliable, reproducible models are available for pure SI animal model to investigate therapeutic options for ALI/ARDS without the confounding variables introduced by cutaneous burn or other pathology.ObjectiveTo develop a small animal model of pure SI-induced ALI and to use this model for eventual testing of novel therapeutics for ALI.MethodsRats were exposed to smoke using a custom-made smoke generator. Peripheral oxygen saturation (SpO2), heart rate, arterial blood gas, and chest X-ray (CXR) were measured before and after SI. Wet/dry weight (W/D) ratio, lung injury score and immunohistochemical staining of cleaved caspase 3 were performed on harvested lung tissues of healthy and SI animals.ResultsThe current study demonstrates the induction of ALI in rats after SI as reflected by a significant, sustained decrease in SpO2 and the development of diffuse bilateral pulmonary infiltrates on CXR. Lung tissue of animals exposed to SI showed increased inflammation, oedema and apoptosis as reflected by the increase in W/D ratio, injury score and cleaved caspase 3 level of the harvested tissues compared with healthy animals.ConclusionWe have successfully developed a small animal model of pure SI-induced ALI. This model is offered to the scientific community as a reliable model of isolated pulmonary SI-induced injury without the confounding variables of cutaneous injury or other systemic pathology to be used for study of novel therapeutics or other investigation.

scholarly journals Intraoperative Radiation Therapy Combined with Hyperthermia against Pancreatic Carcinoma.

1992 ◽  
Vol 166 (3) ◽  
pp. 395-401 ◽  
Author(s):  
SHOGO YAMADA ◽  
YOSHIHIRO TAKAI ◽  
KENJI NEMOTO ◽  
YOSHIHIRO OGAWA ◽  
YOSHIHISA KAKUTO ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Pancreatic Carcinoma ◽  
Intraoperative Radiation Therapy ◽  
Intraoperative Radiation
Sign in / Sign up

Export Citation Format

Share Document