Use of Monte Carlo simulations with a realistic rat phantom for examining the correlation between hematopoietic system response and red marrow absorbed dose in Brown Norway rats undergoing radionuclide therapy with177Lu- and90Y-BR96 mAbs

2012 ◽  
Vol 39 (7Part1) ◽  
pp. 4434-4443 ◽  
Author(s):  
Erik Larsson ◽  
Michael Ljungberg ◽  
Linda Mårtensson ◽  
Rune Nilsson ◽  
Jan Tennvall ◽  
...  
Keyword(s):  
Monte Carlo ◽  
Monte Carlo Simulations ◽  
Radionuclide Therapy ◽  
Absorbed Dose ◽  
Brown Norway ◽  
System Response ◽  
Hematopoietic System ◽  
Red Marrow ◽  
Norway Rats

scholarly journals A Monte Carlo Determination of Dose and Range Uncertainties for Preclinical Studies with a Proton Beam

Cancers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1889
Author(s):  
Arthur Bongrand ◽  
Charbel Koumeir ◽  
Daphnée Villoing ◽  
Arnaud Guertin ◽  
Ferid Haddad ◽  
...  
Keyword(s):  
Monte Carlo ◽  
Monte Carlo Simulations ◽  
Proton Beam ◽  
Dose Response ◽  
Small Animal ◽  
Absorbed Dose ◽  
Normal Tissue Damage ◽  
Dose Homogeneity ◽  
And Control ◽  
The Impact

Proton therapy (PRT) is an irradiation technique that aims at limiting normal tissue damage while maintaining the tumor response. To study its specificities, the ARRONAX cyclotron is currently developing a preclinical structure compatible with biological experiments. A prerequisite is to identify and control uncertainties on the ARRONAX beamline, which can lead to significant biases in the observed biological results and dose–response relationships, as for any facility. This paper summarizes and quantifies the impact of uncertainty on proton range, absorbed dose, and dose homogeneity in a preclinical context of cell or small animal irradiation on the Bragg curve, using Monte Carlo simulations. All possible sources of uncertainty were investigated and discussed independently. Those with a significant impact were identified, and protocols were established to reduce their consequences. Overall, the uncertainties evaluated were similar to those from clinical practice and are considered compatible with the performance of radiobiological experiments, as well as the study of dose–response relationships on this proton beam. Another conclusion of this study is that Monte Carlo simulations can be used to help build preclinical lines in other setups.

scholarly journals Monte Carlo simulations of absorbed dose in a mouse phantom from 18-fluorine compounds

2007 ◽  
Vol 34 (3) ◽  
pp. 1026-1036 ◽  
Author(s):  
Richard Taschereau ◽  
Arion F. Chatziioannou
Keyword(s):  
Monte Carlo ◽  
Monte Carlo Simulations ◽  
Absorbed Dose ◽  
Fluorine Compounds

Fast Calculation of the Statistics of the Forced Response of Mistuned Bladed Disk Assemblies With Friction Contacts

2002 ◽  
Author(s):  
Walter Sextro ◽  
Lars Panning ◽  
Florian Go¨tting ◽  
Karl Popp
Keyword(s):  
Monte Carlo ◽  
Monte Carlo Simulations ◽  
Frequency Response ◽  
Approximate Method ◽  
Natural Frequencies ◽  
Computation Time ◽  
System Response ◽  
Response Functions ◽  
Frequency Response Functions ◽  
Bladed Disk

In turbomachinery one major problem is still the calculation and the optimization of the spatial vibrations of mistuned bladed disk assemblies with friction contacts. Friction contacts are widely used to reduce dynamic stresses in turbine blades. Due to dry friction and the relative motion of the contact planes energy is dissipated. This effect results in a reduction of blade vibration amplitudes. In the case of a tuned bladed disk cyclic boundary conditions can be used for the calculation of the dynamic response. For a mistuned bladed disk the complete system has to be modeled and simulated. To reduce the computation time the so-called substructure method is applied. This method is based on the modal description of each substructure, especially disk and blades, combined with a reduction of the degrees of freedom, to describe the dynamics of each component. The spatial dynamical behavior of each component is considered and described by the mode shapes, natural frequencies and modal damping ratios. Using the Harmonic Balance Method the nonlinear friction forces can be linearized. From here it is possible to calculate the frequency response functions of a mistuned bladed disk assembly with friction contacts. In many cases Monte-Carlo simulations are used to find regions, where the system response is sensitive to parameter uncertainties like the natural frequencies of the blades. These simulations require a large computation time. Therefore, an approximate method is developed to calculate the envelopes of the frequency response functions for statistically varying natural frequencies of the blades. This method is based on a sensitivity analysis and the Weibull-distribution of the vibration amplitudes. From here, a measure for the strength of localization for mistuned cyclic systems is derived. Regions, where localization can occur with a high probability, can be calculated by this method. The mean value and the standard deviation of the vibration amplitudes are calculated by simulation and by the approximate method. The comparisons between the approximate method and the Monte-Carlo simulations show a good agreement. Therefore, applying this method leads to remarkable reduction of computation time and gives a quick insight into the system behavior. The approximate method can also be applied to systems, that include the elasticity of the disk and/or the coupling by shrouds or other friction devices.

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