WE-A-BRB-02: Gold Nanoparticle-Aided Brachytherapy with Vascular Dose Painting: Estimation of Dose Enhancement to the Endothelial Cell Nucleus

2011 ◽  
Vol 38 (6Part31) ◽  
pp. 3791-3792
Author(s):  
W Ngwa ◽  
M Makrigiorgos ◽  
R Berbeco
Keyword(s):  
Endothelial Cell ◽  
Gold Nanoparticle ◽  
Cell Nucleus ◽  
Dose Painting ◽  
Dose Enhancement

scholarly journals Low Z target switching to increase tumor endothelial cell dose enhancement during gold nanoparticle-aided radiation therapy

2015 ◽  
Vol 43 (1) ◽  
pp. 436-442 ◽  
Author(s):  
Ross I. Berbeco ◽  
Alexandre Detappe ◽  
Panogiotis Tsiamas ◽  
David Parsons ◽  
Mammo Yewondwossen ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Endothelial Cell ◽  
Gold Nanoparticle ◽  
Dose Enhancement ◽  
Tumor Endothelial Cell ◽  
Cell Dose

A detailed experimental and Monte Carlo analysis of gold nanoparticle dose enhancement using 6 MV and 18 MV external beam energies in a macroscopic scale

2021 ◽  
Vol 171 ◽  
pp. 109638
Author(s):  
Tara Gray ◽  
Nema Bassiri ◽  
Shaquan David ◽  
Devanshi Yogeshkumar Patel ◽  
Sotirios Stathakis ◽  
...  
Keyword(s):  
Monte Carlo ◽  
Gold Nanoparticle ◽  
Monte Carlo Analysis ◽  
External Beam ◽  
Macroscopic Scale ◽  
Dose Enhancement

Nanoparticle dose enhancement of synchrotron radiation in PRESAGE dosimeters

2020 ◽  
Vol 27 (6) ◽  
pp. 1590-1600
Author(s):  
Frank M. Gagliardi ◽  
Rick D. Franich ◽  
Moshi Geso
Keyword(s):  
Gold Nanoparticles ◽  
Synchrotron Radiation ◽  
Gold Nanoparticle ◽  
Size Dependence ◽  
Absorbed Dose ◽  
Nanoparticle Concentration ◽  
Dose Enhancement ◽  
X Ray ◽  
Bismuth Nanoparticles ◽  
Synchrotron Beam

The physical absorbed dose enhancement by the inclusion of gold and bismuth nanoparticles fabricated into water-equivalent PRESAGE dosimeters was investigated. Nanoparticle-loaded water-equivalent PRESAGE dosimeters were irradiated with superficial, synchrotron and megavoltage X-ray beams. The change in optical density of the dosimeters was measured using UV–Vis spectrophotometry pre- and post-irradiation using a wavelength of 630 nm. Dose enhancement was measured for 5 nm and 50 nm monodispersed gold nanoparticles, 5–50 nm polydispersed bismuth nanoparticles, and 80 nm monodispersed bismuth nanoparticles at concentrations from 0.25 mM to 2 mM. The dose enhancement was highest for the 95.3 keV mean energy synchrotron beam (16–32%) followed by the 150 kVp superficial beam (12–21%) then the 6 MV beam (2–5%). The bismuth nanoparticle-loaded dosimeters produced a larger dose enhancement than the gold nanoparticle-loaded dosimeters in the synchrotron beam for the same concentration. For the superficial and megavoltage beams the dose enhancement was similar for both species of nanoparticles. The dose enhancement increased with nanoparticle concentration in the dosimeters; however, there was no observed nanoparticle size dependence on the dose enhancement.

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