SU-E-J-111: Skin Entrance Dose Estimation for the Radiographic Image Guidance at the Various Anatomic Regions of the CyberKnife Radiation Treatment

2011 ◽  
Vol 38 (6Part9) ◽  
pp. 3468-3468
Author(s):  
J Kim ◽  
S Lee ◽  
D North ◽  
B Curran ◽  
E Sternick
2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 4131-4131
Author(s):  
G. Starling ◽  
C. D. Fuller ◽  
C. R. Thomas ◽  
M. Fuss

4131 Background: The purpose of this study is to determine the effect of image-guided radiotherapy on survival in adenocarcinoma of the biliary tract. Methods: Between 1995 and 2005, 43 pts with primary biliary tract (gallbladder or bile duct) neoplasms were treated with radiotherapy. 26 of the pts were female and 17 were male. Their average age at registration was 64, and ranged from 25 to 86. Twenty-five pts (58%) were Hispanic, while 18 (42%) were white. 31 pts (72%) underwent surgical treatment, most having cholecystecomy (50%). 29 pts (67%) had chemotherapy: 21 (72%) were given fluorouracil-based drugs, 2 (7%) received gemcitabine, and 6 (21%) received other agents. 23 pts (53%) received conventional radiation treatment using AP/PA, AP/PA with opposing lateral, or AP with opposing lateral fields. 20 pts (47%) received IG-IMRT using Nomos Peacock and daily ultrasound image guidance (BAT, Nomos, Cranberry, PA). For daily ultrasound-based image-guidance, sagittal and axial ultrasound images were acquired, and used to align pt anatomy through superimposition of CT derived organ and vascular guidance structures. Pts were treated using a boost technique to a reduced volume at gross disease after an initial dose to gross tumor and clinically evident microscopic disease. Results: Median dose to target was 54 Gy, with median conventional and IG-IMRT total doses of 48.6 and 60 Gy respectively (p=0.05). Treatment was well tolerated, with only two patients reporting RTOG grade 3 toxicity. All other patients exhibited Grade ≤2, with 23/43 reporting Grade ≤1 The median survival time from the date of registration for all patients was 8.7 months; conventional RT pts had a median survival of 6.1 months, while the IG-IMRT cohort had a median survival of 11.4 months (p = .02). Conclusions: Ultrasound-based image-guided IMRT is a feasible mechanism of delivering moderate dose escalation in conjunction with tighter safety margins, resulting in acceptable acute toxicities. Early survival data with this novel technique are encouraging and demonstrate a notable survival differential using image guided radiotherapy as component of multi-modaility regimens. No significant financial relationships to disclose.


2018 ◽  
Vol 91 (1090) ◽  
pp. 20180287 ◽  
Author(s):  
Yoshihiro Ueda ◽  
Naamit K Gerber ◽  
Indra J Das

2021 ◽  
Vol 11 (19) ◽  
pp. 9101
Author(s):  
Jason Paino ◽  
Micah Barnes ◽  
Elette Engels ◽  
Jeremy Davis ◽  
Susanna Guatelli ◽  
...  

Synchrotron microbeam radiation therapy is a promising pre-clinical radiation treatment modality; however, it comes with many technical challenges. This study describes the image guidance protocol used for Australia’s first long-term pre-clinical MRT treatment of rats bearing 9L gliosarcoma tumours. The protocol utilises existing infrastructure available at the Australian Synchrotron and the adjoining Monash Biomedical Imaging facility. The protocol is designed and optimised to treat small animals utilising high-resolution clinical CT for patient specific tumour identification, coupled with conventional radiography, using the recently developed SyncMRT program for image guidance. Dosimetry performed in small animal phantoms shows patient dose is comparable to standard clinical doses, with a CT associated dose of less than 1.39cGy and a planar radiograh dose of less than 0.03cGy. Experimental validation of alignment accuracy with radiographic film demonstrates end to end accuracy of less than ±0.34mm in anatomical phantoms. Histological analysis of tumour-bearing rats treated with microbeam radiation therapy verifies that tumours are targeted well within applied treatment margins. To date, this technique has been used to treat 35 tumour-bearing rats.


2004 ◽  
Vol 41 (sup4) ◽  
pp. 124-127
Author(s):  
Hyong Geun Yun ◽  
Soon Nyung Huh ◽  
Hyoung Koo Lee ◽  
Hong Gyun Woo ◽  
Kyo Chul Shin ◽  
...  

2016 ◽  
Vol 21 (4) ◽  
pp. 1327-1333 ◽  
Author(s):  
Ralf Kurt Willy Schulze ◽  
Catrin Cremers ◽  
Heiko Karle ◽  
Hugo de las Heras Gala

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