SU-E-I-137: Incorporation of Regional Homogeneity in Seed-Based Resting-State Functional MRI Analysis Improves Default-Mode Network Detection in Patients with ICA Stenosis

2011 ◽  
Vol 38 (6Part6) ◽  
pp. 3427-3427
Author(s):  
F.X. Yan ◽  
T.H. Lee ◽  
H.F. Wong ◽  
H.L. Liu
Keyword(s):  
Functional Mri ◽  
Default Mode Network ◽  
Resting State ◽  
Regional Homogeneity ◽  
Default Mode ◽  
Ica Stenosis

Decreased connectivity of the default mode network in pathological gambling: A resting state functional MRI study

2014 ◽  
Vol 583 ◽  
pp. 120-125 ◽  
Author(s):  
Myung Hun Jung ◽  
Jae-Hun Kim ◽  
Young-Chul Shin ◽  
Wi Hoon Jung ◽  
Joon Hwan Jang ◽  
...  
Keyword(s):  
Pathological Gambling ◽  
Functional Mri ◽  
Default Mode Network ◽  
Resting State ◽  
Default Mode ◽  
Mri Study

Targeting Default Mode Network Dysfunction in Persons at Risk of Alzheimer’s Disease with Transcranial Magnetic Stimulation (NEST4AD): Rationale and Study Design

2021 ◽  
Vol 83 (4) ◽  
pp. 1877-1889
Author(s):  
Michela Pievani ◽  
Anna Mega ◽  
Giulia Quattrini ◽  
Giacomo Guidali ◽  
Clarissa Ferrari ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
At Risk ◽  
Transcranial Magnetic Stimulation ◽  
Functional Mri ◽  
Default Mode Network ◽  
Resting State ◽  
Multimodal Imaging ◽  
Magnetic Stimulation ◽  
Default Mode ◽  
E4 Allele

Background: Default mode network (DMN) dysfunction is well established in Alzheimer’s disease (AD) and documented in both preclinical stages and at-risk subjects, thus representing a potential disease target. Multi-sessions of repetitive transcranial magnetic stimulation (rTMS) seem capable of modulating DMN dynamics and memory in healthy individuals and AD patients; however, the potential of this approach in at-risk subjects has yet to be tested. Objective: This study will test the effect of rTMS on the DMN in healthy older individuals carrying the strongest genetic risk factor for AD, the Apolipoprotein E (APOE) ɛ4 allele. Methods: We will recruit 64 older participants without cognitive deficits, 32 APOE ɛ4 allele carriers and 32 non-carriers as a reference group. Participants will undergo four rTMS sessions of active (high frequency) or sham DMN stimulation. Multimodal imaging exam (including structural, resting-state, and task functional MRI, and diffusion tensor imaging), TMS with concurrent electroencephalography (TMS-EEG), and cognitive assessment will be performed at baseline and after the stimulation sessions. Results: We will assess changes in DMN connectivity with resting-state functional MRI and TMS-EEG, as well as changes in memory performance in APOE ɛ4 carriers. We will also investigate the mechanisms underlying DMN modulation through the assessment of correlations with measures of neuronal activity, excitability, and structural connectivity with multimodal imaging. Conclusion: The results of this study will inform on the physiological and cognitive outcomes of DMN stimulation in subjects at risk for AD and on the possible mechanisms. These results may outline the design of future non-pharmacological preventive interventions for AD.

scholarly journals Brain default-mode network abnormalities in hepatic encephalopathy: A resting-state functional MRI study

2011 ◽  
Vol 33 (6) ◽  
pp. 1384-1392 ◽  
Author(s):  
Longjiang Zhang ◽  
Rongfeng Qi ◽  
Shengyong Wu ◽  
Jianhui Zhong ◽  
Yuan Zhong ◽  
...  
Keyword(s):  
Hepatic Encephalopathy ◽  
Functional Mri ◽  
Default Mode Network ◽  
Resting State ◽  
Default Mode ◽  
Mri Study

P3-258: Resting State Functional Mri in Alzheimer’S Disease: an Innovative Approach ror Robust Extraction of the Default Mode Network

2016 ◽  
Vol 12 ◽  
pp. P930-P930
Author(s):  
Hanne Struyfs ◽  
Vasilis Terzopoulos ◽  
Frank De Belder ◽  
Paul M. Parizel ◽  
Wim Van Hecke ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Functional Mri ◽  
Default Mode Network ◽  
Resting State ◽  
Innovative Approach ◽  
Default Mode

scholarly journals Characterization of Resting State Default Mode Network in Individuals with HbSS and HbSC, and Healthy Controls Using 7-Tesla Human MRI

Blood ◽  
2021 ◽  
Vol 138 (Supplement 1) ◽  
pp. 126-126
Author(s):  
Nadim Farhat ◽  
Helmet Karim ◽  
Tales Santini ◽  
Caterina Rosano ◽  
Leticia Candra ◽  
...  
Keyword(s):  
Functional Mri ◽  
Negative Correlation ◽  
Default Mode Network ◽  
Resting State ◽  
Ad Hoc ◽  
Brain Aging ◽  
Significant Negative Correlation ◽  
7 Tesla ◽  
Default Mode ◽  
Significant Difference

Abstract Sickle cell disease (SCD) is complicated by accelerated brain aging and cerebrovascular complications leading to structural brain damage and altered resting state functional connectivity (RS-FC). Investigation of the Default Mode Network (DMN), the most studied of the RS-FC networks, by functional MRI may provide insight into the neurological and neuropsychiatric complications of SCD. Prior studies have largely focused on the HbSS genotype of SCD as opposed to the HbSC genotype, which accounts for 30% of the total SCD cases in the US. Both genotypes are expected to impact brain disease, but in different manner. The aim of this study was to characterize the DMN in patients with HbSC, HbSS and healthy race and age-matched controls using state of the art 7-Tesla (7T) magnetic resonance imaging (MRI) with high contrast- and signal- to-noise ratios. On the day of the MRI scanning, participants were administered the brief pain inventory questionnaire (BPI), the digit symbol substitution test of cognitive function, and underwent basic blood work. Controls (n= 43, 53% female, mean age = 36+/-12 years), patients with HbSS (n=19, 63% female, mean age= 36+/-12) and HbSC (n=16 (50% female, mean age=36+/-13) were scanned using a 7T Siemens Magnetom scanner with the Tic Tac Toe radiofrequency coil system (Ibrahim et al., 2013). We obtained whole brain structural T1-weighted images and blood oxygenations level dependent resting state functional MRI (RS-fMRI). During the RS-fMRI, participants were instructed to keep their eyes open, look at a fixation cross, and lie without motion in the scanner. To identify significant differences in RS-FC between the groups, we conducted voxel-wise nonparametric analysis of variance. In the cortical areas with significant clusters, we ran ad-hoc t-tests (controls vs. HbSS, HbSC vs. HbSS, 1000 permutations, uncorrected cluster forming threshold = p < 0.001, family-wise error (FWE) rate=0.05) and we added age and sex as confounders. Then, we correlated RS-FC and the following variables: age, hemoglobin, BPI total, and DSST score. We found a significant difference between the three groups in the DMN (Fig 1) (p=0.0002). The ad-hoc t-tests showed that in the DMN, the RS-FC for the medial prefrontal cortex (mPFC) was significantly higher for the controls when compared to patients with HbSS (p=0.002). RS-FC for the mPFC was also significantly higher in patients with HbSC as compared to HbSS (p=0.001). There was a non-significant trend towards lower RS-FC in patients with HbSC as compared to controls. We also found weak non-significant negative correlation, (r= -0.24, p=0.1315), a strong significant negative correlation (r=-0.5, p=0.04) and very strong significant negative correlation (r=-0.8, p=0.001) between age and RS-FC in the mPFC for controls, HbSC, and HbSS patients, respectively. (Fig 2). We did not find any significant correlation between the RS-FC in the three groups and Hb levels, BPI total, and DSST score. In this work and for the first time, using 7T human MRI we identified altered RS-FC between SCD genotypes and between controls and patients with HbSS. It is notable that the RS-FC for HbSC patients was intermediate between that of the other two groups. Our results imply the RS-FC levels might be susceptible to disease genotype and not necessarily Hb levels, cognition and pain. The finding of a stronger correlation between age and FC in patients with SCD as compared to controls corroborates the notion that accelerated brain aging is operant in SCD. Figure 1 Figure 1. Disclosures Novelli: Novartis Pharmaceuticals: Consultancy.

Intrinsic brain abnormalities in young healthy adults with childhood trauma: A resting-state functional magnetic resonance imaging study of regional homogeneity and functional connectivity

2016 ◽  
Vol 51 (6) ◽  
pp. 614-623 ◽  
Author(s):  
Shaojia Lu ◽  
Weijia Gao ◽  
Zhaoguo Wei ◽  
Dandan Wang ◽  
Shaohua Hu ◽  
...  
Keyword(s):  
Functional Magnetic Resonance Imaging ◽  
Childhood Trauma ◽  
Default Mode Network ◽  
Resting State ◽  
Regional Homogeneity ◽  
Middle Temporal Gyrus ◽  
Functional Magnetic Resonance ◽  
Default Mode ◽  
Left Middle Temporal Gyrus ◽  
Left Middle

Objective: Childhood trauma confers great risk for the development of multiple psychiatric disorders; however, the neural basis for this association is still unknown. The present resting-state functional magnetic resonance imaging study aimed to detect the effects of childhood trauma on brain function in a group of young healthy adults. Methods: In total, 24 healthy individuals with childhood trauma and 24 age- and sex-matched adults without childhood trauma were recruited. Each participant underwent resting-state functional magnetic resonance imaging scanning. Intra-regional brain activity was evaluated by regional homogeneity method and compared between groups. Areas with altered regional homogeneity were further selected as seeds in subsequent functional connectivity analysis. Statistical analyses were performed by setting current depression and anxiety as covariates. Results: Adults with childhood trauma showed decreased regional homogeneity in bilateral superior temporal gyrus and insula, and the right inferior parietal lobule, as well as increased regional homogeneity in the right cerebellum and left middle temporal gyrus. Regional homogeneity values in the left middle temporal gyrus, right insula and right cerebellum were correlated with childhood trauma severity. In addition, individuals with childhood trauma also exhibited altered default mode network, cerebellum-default mode network and insula-default mode network connectivity when the left middle temporal gyrus, right cerebellum and right insula were selected as seed area, respectively. Conclusion: The present outcomes suggest that childhood trauma is associated with disturbed intrinsic brain function, especially the default mode network, in adults even without psychiatric diagnoses, which may mediate the relationship between childhood trauma and psychiatric disorders in later life.

Sign in / Sign up

Export Citation Format

Share Document