scholarly journals Brain default-mode network abnormalities in hepatic encephalopathy: A resting-state functional MRI study

2011 ◽  
Vol 33 (6) ◽  
pp. 1384-1392 ◽  
Author(s):  
Longjiang Zhang ◽  
Rongfeng Qi ◽  
Shengyong Wu ◽  
Jianhui Zhong ◽  
Yuan Zhong ◽  
...  
Keyword(s):  
Hepatic Encephalopathy ◽  
Functional Mri ◽  
Default Mode Network ◽  
Resting State ◽  
Default Mode ◽  
Mri Study

Decreased connectivity of the default mode network in pathological gambling: A resting state functional MRI study

2014 ◽  
Vol 583 ◽  
pp. 120-125 ◽  
Author(s):  
Myung Hun Jung ◽  
Jae-Hun Kim ◽  
Young-Chul Shin ◽  
Wi Hoon Jung ◽  
Joon Hwan Jang ◽  
...  
Keyword(s):  
Pathological Gambling ◽  
Functional Mri ◽  
Default Mode Network ◽  
Resting State ◽  
Default Mode ◽  
Mri Study

scholarly journals Cognition and the Default Mode Network in Children with Sickle Cell Disease: A Resting State Functional MRI Study

PLoS ONE ◽  
2016 ◽  
Vol 11 (6) ◽  
pp. e0157090 ◽  
Author(s):  
Raffaella Colombatti ◽  
Marta Lucchetta ◽  
Maria Montanaro ◽  
Patrizia Rampazzo ◽  
Mario Ermani ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Functional Mri ◽  
Sickle Cell ◽  
Default Mode Network ◽  
Resting State ◽  
Cell Disease ◽  
Default Mode ◽  
Mri Study

Targeting Default Mode Network Dysfunction in Persons at Risk of Alzheimer’s Disease with Transcranial Magnetic Stimulation (NEST4AD): Rationale and Study Design

2021 ◽  
Vol 83 (4) ◽  
pp. 1877-1889
Author(s):  
Michela Pievani ◽  
Anna Mega ◽  
Giulia Quattrini ◽  
Giacomo Guidali ◽  
Clarissa Ferrari ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
At Risk ◽  
Transcranial Magnetic Stimulation ◽  
Functional Mri ◽  
Default Mode Network ◽  
Resting State ◽  
Multimodal Imaging ◽  
Magnetic Stimulation ◽  
Default Mode ◽  
E4 Allele

Background: Default mode network (DMN) dysfunction is well established in Alzheimer’s disease (AD) and documented in both preclinical stages and at-risk subjects, thus representing a potential disease target. Multi-sessions of repetitive transcranial magnetic stimulation (rTMS) seem capable of modulating DMN dynamics and memory in healthy individuals and AD patients; however, the potential of this approach in at-risk subjects has yet to be tested. Objective: This study will test the effect of rTMS on the DMN in healthy older individuals carrying the strongest genetic risk factor for AD, the Apolipoprotein E (APOE) ɛ4 allele. Methods: We will recruit 64 older participants without cognitive deficits, 32 APOE ɛ4 allele carriers and 32 non-carriers as a reference group. Participants will undergo four rTMS sessions of active (high frequency) or sham DMN stimulation. Multimodal imaging exam (including structural, resting-state, and task functional MRI, and diffusion tensor imaging), TMS with concurrent electroencephalography (TMS-EEG), and cognitive assessment will be performed at baseline and after the stimulation sessions. Results: We will assess changes in DMN connectivity with resting-state functional MRI and TMS-EEG, as well as changes in memory performance in APOE ɛ4 carriers. We will also investigate the mechanisms underlying DMN modulation through the assessment of correlations with measures of neuronal activity, excitability, and structural connectivity with multimodal imaging. Conclusion: The results of this study will inform on the physiological and cognitive outcomes of DMN stimulation in subjects at risk for AD and on the possible mechanisms. These results may outline the design of future non-pharmacological preventive interventions for AD.

P3-258: Resting State Functional Mri in Alzheimer’S Disease: an Innovative Approach ror Robust Extraction of the Default Mode Network

2016 ◽  
Vol 12 ◽  
pp. P930-P930
Author(s):  
Hanne Struyfs ◽  
Vasilis Terzopoulos ◽  
Frank De Belder ◽  
Paul M. Parizel ◽  
Wim Van Hecke ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Functional Mri ◽  
Default Mode Network ◽  
Resting State ◽  
Innovative Approach ◽  
Default Mode
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