SU-GG-BRC-01: Modeling Myocardial Mn2+ Efflux Rates Using Manganese-Enhanced MRI T1 Mapping in a Murine Myocardial Infarction Model

2009 ◽  
Vol 36 (6Part19) ◽  
pp. 2681-2681
Author(s):  
B Waghorn ◽  
J Liu ◽  
A Baba ◽  
T Matsuda ◽  
N Yanasak ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
T1 Mapping ◽  
Enhanced Mri ◽  
Manganese Enhanced Mri

scholarly journals Native T1 mapping for characterization of acute and chronic myocardial infarction in swine: Comparison with contrast-enhanced MRI

2018 ◽  
Vol 47 (5) ◽  
pp. spcone-spcone
Author(s):  
Xi Liu ◽  
Jiang-long Hou ◽  
Zhi-gang Yang ◽  
Chun-chao Xia ◽  
Lin-jun Xie ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
T1 Mapping ◽  
Chronic Myocardial Infarction ◽  
Native T1 ◽  
Enhanced Mri ◽  
Contrast Enhanced ◽  
Contrast Enhanced Mri

scholarly journals Myocardial viability of the peri-infarct region measured by T1 mapping post manganese-enhanced MRI correlates with LV dysfunction

2019 ◽  
Vol 281 ◽  
pp. 8-14
Author(s):  
Yuko Tada ◽  
Shahriar Heidary ◽  
Atsushi Tachibana ◽  
Junaid Zaman ◽  
Evgenios Neofytou ◽  
...  
Keyword(s):  
Myocardial Viability ◽  
T1 Mapping ◽  
Infarct Region ◽  
Lv Dysfunction ◽  
Enhanced Mri ◽  
Manganese Enhanced Mri

scholarly journals Assessment of stunned and viable myocardium using manganese-enhanced MRI

Open Heart ◽  
2021 ◽  
Vol 8 (1) ◽  
pp. e001646
Author(s):  
Nick B Spath ◽  
Trisha Singh ◽  
Giorgos Papanastasiou ◽  
Andrew Baker ◽  
Rob J Janiczek ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Intracellular Calcium ◽  
Myocardial Viability ◽  
Viable Myocardium ◽  
Calcium Handling ◽  
Infarcted Myocardium ◽  
Enhanced Mri ◽  
Manganese Uptake ◽  
Healthy Control ◽  
Manganese Enhanced Mri

ObjectiveIn a proof-of-concept study, to quantify myocardial viability in patients with acute myocardial infarction using manganese-enhanced MRI (MEMRI), a measure of intracellular calcium handling.MethodsHealthy volunteers (n=20) and patients with ST-elevation myocardial infarction (n=20) underwent late gadolinium enhancement (LGE) using gadobutrol and MEMRI using manganese dipyridoxyl diphosphate. Patients were scanned ≤7 days after reperfusion and rescanned after 3 months. Differential manganese uptake was described using a two-compartment model.ResultsAfter manganese administration, healthy control and remote non-infarcted myocardium showed a sustained 25% reduction in T1 values (mean reductions, 288±34 and 281±12 ms). Infarcted myocardium demonstrated less T1 shortening than healthy control or remote myocardium (1157±74 vs 859±36 and 835±28 ms; both p<0.0001) with intermediate T1 values (1007±31 ms) in peri-infarct regions. Compared with LGE, MEMRI was more sensitive in detecting dysfunctional myocardium (dysfunctional fraction 40.5±11.9 vs 34.9%±13.9%; p=0.02) and tracked more closely with abnormal wall motion (r2=0.72 vs 0.55; p<0.0001). Kinetic modelling showed reduced myocardial manganese influx between remote, peri-infarct and infarct regions, enabling absolute discrimination of infarcted myocardium. After 3 months, manganese uptake increased in peri-infarct regions (16.5±3.5 vs 22.8±3.5 mL/100 g/min, p<0.0001), but not the remote (23.3±2.8 vs 23.0±3.2 mL/100 g/min, p=0.8) or infarcted (11.5±3.7 vs 14.0±1.2 mL/100 g/min, p>0.1) myocardium.ConclusionsThrough visualisation of intracellular calcium handling, MEMRI accurately differentiates infarcted, stunned and viable myocardium, and correlates with myocardial dysfunction better than LGE. MEMRI holds major promise in directly assessing myocardial viability, function and calcium handling across a range of cardiac diseases.Trial registration numbersNCT03607669; EudraCT number 2016-003782-25.

scholarly journals Myocardial Viability Imaging using Manganese‐Enhanced MRI in the First Hours after Myocardial Infarction

2021 ◽  
pp. 2003987
Author(s):  
Nur Hayati Jasmin ◽  
May Zaw Thin ◽  
Robert D. Johnson ◽  
Laurence H. Jackson ◽  
Thomas A. Roberts ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Myocardial Viability ◽  
Enhanced Mri ◽  
Manganese Enhanced Mri ◽  
Viability Imaging

Monitoring dynamic alterations in calcium homeostasis byT1-weighted andT1-mapping cardiac manganese-enhanced MRI in a murine myocardial infarction model

2008 ◽  
Vol 21 (10) ◽  
pp. 1102-1111 ◽  
Author(s):  
Ben Waghorn ◽  
Tiffany Edwards ◽  
Yuhui Yang ◽  
Kai-Hsiang Chuang ◽  
Nathan Yanasak ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Calcium Homeostasis ◽  
Enhanced Mri ◽  
Manganese Enhanced Mri

Myocardial infarction quantification with Manganese-Enhanced MRI (MEMRI) in mice using a 3T clinical scanner

2010 ◽  
Vol 23 (5) ◽  
pp. 503-513 ◽  
Author(s):  
Bénédicte M. A. Delattre ◽  
Vincent Braunersreuther ◽  
Jean-Noël Hyacinthe ◽  
Lindsey A. Crowe ◽  
François Mach ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Enhanced Mri ◽  
Manganese Enhanced Mri ◽  
Clinical Scanner

TU-D-332-04: Modulating Mn2+ Efflux with SEA0400, Using Cardiac Manganese-Enhanced MRI (MEMRI) T1-Mapping in a Murine Model

2008 ◽  
Vol 35 (6Part21) ◽  
pp. 2906-2906
Author(s):  
B Waghorn ◽  
Y Yang ◽  
B Klein ◽  
A Baba ◽  
T Matsuda ◽  
...  
Keyword(s):  
Murine Model ◽  
T1 Mapping ◽  
Enhanced Mri ◽  
Manganese Enhanced Mri

scholarly journals Manganese-enhanced MRI of the myocardium

Heart ◽  
2019 ◽  
Vol 105 (22) ◽  
pp. 1695-1700 ◽  
Author(s):  
Nick B Spath ◽  
Gerard Thompson ◽  
Andrew H Baker ◽  
Marc R Dweck ◽  
David E Newby ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Myocardial Viability ◽  
Imaging Modality ◽  
Mri Contrast Agents ◽  
Calcium Handling ◽  
Contrast Imaging ◽  
Translational Study ◽  
Enhanced Mri ◽  
Ability To Act ◽  
Manganese Enhanced Mri

Gadolinium-based contrast media are widely used in cardiovascular MRI to identify and to highlight the intravascular and extracellular space. After gadolinium, manganese has the second highest paramagnetic moment and was one of the first MRI contrast agents assessed in humans. Over the last 50 years, manganese-enhanced MRI (MEMRI) has emerged as a complementary approach enabling intracellular myocardial contrast imaging that can identify functional myocardium through its ability to act as a calcium analogue. Early progress was limited by its potential to cause myocardial depression. To overcome this problem, two clinical formulations of manganese were developed using either chelation (manganese dipyridoxyl diphosphate) or coadministration with a calcium compound (EVP1001-1, Eagle Vision Pharmaceuticals). Preclinical studies have demonstrated the efficacy of MEMRI in quantifying myocardial infarction and detecting myocardial viability as well as tracking altered contractility and calcium handling in cardiomyopathy. Recent clinical data suggest that MEMRI has exciting potential in the quantification of myocardial viability in ischaemic cardiomyopathy, the early detection of abnormalities in myocardial calcium handling, and ultimately, in the development of novel therapies for myocardial infarction or heart failure by actively quantifying viable myocardium. The stage is now set for wider clinical translational study of this novel and promising non-invasive imaging modality.

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