Monitoring dynamic alterations in calcium homeostasis byT1-weighted andT1-mapping cardiac manganese-enhanced MRI in a murine myocardial infarction model

2008 ◽  
Vol 21 (10) ◽  
pp. 1102-1111 ◽  
Author(s):  
Ben Waghorn ◽  
Tiffany Edwards ◽  
Yuhui Yang ◽  
Kai-Hsiang Chuang ◽  
Nathan Yanasak ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Calcium Homeostasis ◽  
Enhanced Mri ◽  
Manganese Enhanced Mri

scholarly journals Assessment of stunned and viable myocardium using manganese-enhanced MRI

Open Heart ◽  
2021 ◽  
Vol 8 (1) ◽  
pp. e001646
Author(s):  
Nick B Spath ◽  
Trisha Singh ◽  
Giorgos Papanastasiou ◽  
Andrew Baker ◽  
Rob J Janiczek ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Intracellular Calcium ◽  
Myocardial Viability ◽  
Viable Myocardium ◽  
Calcium Handling ◽  
Infarcted Myocardium ◽  
Enhanced Mri ◽  
Manganese Uptake ◽  
Healthy Control ◽  
Manganese Enhanced Mri

ObjectiveIn a proof-of-concept study, to quantify myocardial viability in patients with acute myocardial infarction using manganese-enhanced MRI (MEMRI), a measure of intracellular calcium handling.MethodsHealthy volunteers (n=20) and patients with ST-elevation myocardial infarction (n=20) underwent late gadolinium enhancement (LGE) using gadobutrol and MEMRI using manganese dipyridoxyl diphosphate. Patients were scanned ≤7 days after reperfusion and rescanned after 3 months. Differential manganese uptake was described using a two-compartment model.ResultsAfter manganese administration, healthy control and remote non-infarcted myocardium showed a sustained 25% reduction in T1 values (mean reductions, 288±34 and 281±12 ms). Infarcted myocardium demonstrated less T1 shortening than healthy control or remote myocardium (1157±74 vs 859±36 and 835±28 ms; both p<0.0001) with intermediate T1 values (1007±31 ms) in peri-infarct regions. Compared with LGE, MEMRI was more sensitive in detecting dysfunctional myocardium (dysfunctional fraction 40.5±11.9 vs 34.9%±13.9%; p=0.02) and tracked more closely with abnormal wall motion (r2=0.72 vs 0.55; p<0.0001). Kinetic modelling showed reduced myocardial manganese influx between remote, peri-infarct and infarct regions, enabling absolute discrimination of infarcted myocardium. After 3 months, manganese uptake increased in peri-infarct regions (16.5±3.5 vs 22.8±3.5 mL/100 g/min, p<0.0001), but not the remote (23.3±2.8 vs 23.0±3.2 mL/100 g/min, p=0.8) or infarcted (11.5±3.7 vs 14.0±1.2 mL/100 g/min, p>0.1) myocardium.ConclusionsThrough visualisation of intracellular calcium handling, MEMRI accurately differentiates infarcted, stunned and viable myocardium, and correlates with myocardial dysfunction better than LGE. MEMRI holds major promise in directly assessing myocardial viability, function and calcium handling across a range of cardiac diseases.Trial registration numbersNCT03607669; EudraCT number 2016-003782-25.

scholarly journals Myocardial Viability Imaging using Manganese‐Enhanced MRI in the First Hours after Myocardial Infarction

2021 ◽  
pp. 2003987
Author(s):  
Nur Hayati Jasmin ◽  
May Zaw Thin ◽  
Robert D. Johnson ◽  
Laurence H. Jackson ◽  
Thomas A. Roberts ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Myocardial Viability ◽  
Enhanced Mri ◽  
Manganese Enhanced Mri ◽  
Viability Imaging

Myocardial infarction quantification with Manganese-Enhanced MRI (MEMRI) in mice using a 3T clinical scanner

2010 ◽  
Vol 23 (5) ◽  
pp. 503-513 ◽  
Author(s):  
Bénédicte M. A. Delattre ◽  
Vincent Braunersreuther ◽  
Jean-Noël Hyacinthe ◽  
Lindsey A. Crowe ◽  
François Mach ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Enhanced Mri ◽  
Manganese Enhanced Mri ◽  
Clinical Scanner

SU-GG-BRC-01: Modeling Myocardial Mn2+ Efflux Rates Using Manganese-Enhanced MRI T1 Mapping in a Murine Myocardial Infarction Model

2009 ◽  
Vol 36 (6Part19) ◽  
pp. 2681-2681
Author(s):  
B Waghorn ◽  
J Liu ◽  
A Baba ◽  
T Matsuda ◽  
N Yanasak ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
T1 Mapping ◽  
Enhanced Mri ◽  
Manganese Enhanced Mri

scholarly journals Manganese-enhanced MRI of the myocardium

Heart ◽  
2019 ◽  
Vol 105 (22) ◽  
pp. 1695-1700 ◽  
Author(s):  
Nick B Spath ◽  
Gerard Thompson ◽  
Andrew H Baker ◽  
Marc R Dweck ◽  
David E Newby ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Myocardial Viability ◽  
Imaging Modality ◽  
Mri Contrast Agents ◽  
Calcium Handling ◽  
Contrast Imaging ◽  
Translational Study ◽  
Enhanced Mri ◽  
Ability To Act ◽  
Manganese Enhanced Mri

Gadolinium-based contrast media are widely used in cardiovascular MRI to identify and to highlight the intravascular and extracellular space. After gadolinium, manganese has the second highest paramagnetic moment and was one of the first MRI contrast agents assessed in humans. Over the last 50 years, manganese-enhanced MRI (MEMRI) has emerged as a complementary approach enabling intracellular myocardial contrast imaging that can identify functional myocardium through its ability to act as a calcium analogue. Early progress was limited by its potential to cause myocardial depression. To overcome this problem, two clinical formulations of manganese were developed using either chelation (manganese dipyridoxyl diphosphate) or coadministration with a calcium compound (EVP1001-1, Eagle Vision Pharmaceuticals). Preclinical studies have demonstrated the efficacy of MEMRI in quantifying myocardial infarction and detecting myocardial viability as well as tracking altered contractility and calcium handling in cardiomyopathy. Recent clinical data suggest that MEMRI has exciting potential in the quantification of myocardial viability in ischaemic cardiomyopathy, the early detection of abnormalities in myocardial calcium handling, and ultimately, in the development of novel therapies for myocardial infarction or heart failure by actively quantifying viable myocardium. The stage is now set for wider clinical translational study of this novel and promising non-invasive imaging modality.

scholarly journals In vivo multi-parametric manganese-enhanced MRI for detecting amyloid plaques in rodent models of Alzheimer’s disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Eugene Kim ◽  
Davide Di Censo ◽  
Mattia Baraldo ◽  
Camilla Simmons ◽  
Ilaria Rosa ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Plaques ◽  
Transgenic Animals ◽  
Surrounding Tissue ◽  
Rodent Models ◽  
Enhanced Mri ◽  
5Xfad Mice ◽  
Manganese Enhanced Mri

AbstractAmyloid plaques are a hallmark of Alzheimer’s disease (AD) that develop in its earliest stages. Thus, non-invasive detection of these plaques would be invaluable for diagnosis and the development and monitoring of treatments, but this remains a challenge due to their small size. Here, we investigated the utility of manganese-enhanced MRI (MEMRI) for visualizing plaques in transgenic rodent models of AD across two species: 5xFAD mice and TgF344-AD rats. Animals were given subcutaneous injections of MnCl2 and imaged in vivo using a 9.4 T Bruker scanner. MnCl2 improved signal-to-noise ratio but was not necessary to detect plaques in high-resolution images. Plaques were visible in all transgenic animals and no wild-types, and quantitative susceptibility mapping showed that they were more paramagnetic than the surrounding tissue. This, combined with beta-amyloid and iron staining, indicate that plaque MR visibility in both animal models was driven by plaque size and iron load. Longitudinal relaxation rate mapping revealed increased manganese uptake in brain regions of high plaque burden in transgenic animals compared to their wild-type littermates. This was limited to the rhinencephalon in the TgF344-AD rats, while it was most significantly increased in the cortex of the 5xFAD mice. Alizarin Red staining suggests that manganese bound to plaques in 5xFAD mice but not in TgF344-AD rats. Multi-parametric MEMRI is a simple, viable method for detecting amyloid plaques in rodent models of AD. Manganese-induced signal enhancement can enable higher-resolution imaging, which is key to visualizing these small amyloid deposits. We also present the first in vivo evidence of manganese as a potential targeted contrast agent for imaging plaques in the 5xFAD model of AD.

Manganese-enhanced MRI of the mouse auditory pathway

2008 ◽  
Vol 60 (1) ◽  
pp. 210-212 ◽  
Author(s):  
Takashi Watanabe ◽  
Jens Frahm ◽  
Thomas Michaelis
Keyword(s):  
Auditory Pathway ◽  
Enhanced Mri ◽  
Manganese Enhanced Mri
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