Hypofractionation is a proven safe and effective modality for postoperative whole-breast radiotherapy for early breast cancer patients

2009 ◽  
Vol 36 (6Part1) ◽  
pp. 1927-1930 ◽  
Author(s):  
Stephen L. Brown ◽  
Alan Rodger ◽  
Colin G. Orton
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Early Breast Cancer ◽  
Breast Cancer Patients ◽  
Breast Radiotherapy ◽  
Whole Breast Radiotherapy

Longterm blood cell counts after intraoperative radiotherapy with or without whole breast radiotherapy in breast cancer patients.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e12014-e12014
Author(s):  
Elena Sperk ◽  
Cornelia Wersal ◽  
Christel Weiss ◽  
Anke Keller ◽  
Anette Kipke ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Blood Cell ◽  
Cancer Patients ◽  
Cell Lines ◽  
Breast Cancer Patients ◽  
Breast Radiotherapy ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
Whole Breast Radiotherapy

e12014 Background: After radiotherapy changes in blood cell counts (BCC) can be seen. Leukocytopenia may have a negative impact on the immune system, outcome and quality of life of breast cancer survivors. No reports on changes of the three blood cell lines (leukocytes=WBC, erythrocytes=RBC, thrombocytes=PLT) after IORT w/o whole breast radiotherapy (WBRT) in breast cancer patients have been reported. Methods: 256 patients had IORT during breast conserving surgery. In 198 patients WBRT (46-50Gy/2Gy) + IORT (20Gy) and in 58 patients IORT as accelerated partial breast irradiation=APBI (20Gy) was given. Preoperative BCC were used as baseline. In 214 patients BCC were available after 1-90 days, in 139 during the 1st year, in 86 in the 2nd, in 66 in the 3rd, in 51 in the 4th and in 34 in the 5th year of follow-up. Dunnett-tests were used to calculate adjusted p-values (p<0.05=significant). Results: After IORT/WBRT a decrease of WBC was seen during the 1st year. Afterwards no changes were seen. After IORT APBI no changes were seen during 5 years follow-up. RBC was decreased at all time points after IORT/WBRT, and through the 1st year after IORT APBI. PLT decreased during the 1st year and stayed low during 5 years after IORT/WBRT. No changes in PLT were seen after IORT APBI. Hemoglobin (HGB) decreased after 3 months, during the 1st and 5th year after IORT/WBRT. After IORT APBI, HGB decreased only during the 1st year and stayed stable during follow-up. Conclusions: Decreases of all blood cell lines were seen at least transiently after IORT/WBRT. PLT and RBC stayed decreased. After IORT APBI, HGB and RBC decreased only during the 1st year and WBC and PLT remained stable during the whole follow-up. [Table: see text]

scholarly journals Quantifying the Mitigating Effects of Whole-Breast Radiotherapy and Systemic Treatments on Regional Recurrence Incidence Among Breast Cancer Patients

2020 ◽  
Vol 27 (9) ◽  
pp. 3402-3411 ◽  
Author(s):  
Julia E. C. van Steenhoven ◽  
Anne Kuijer ◽  
Marissa C. van Maaren ◽  
Marleen Roos ◽  
Sjoerd G. Elias ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Regional Recurrence ◽  
Breast Cancer Patients ◽  
Breast Radiotherapy ◽  
Systemic Treatments ◽  
Whole Breast Radiotherapy

Discontinuation of hormone therapy for elderly breast cancer patients after hypofractionated whole-breast radiotherapy

2018 ◽  
Vol 35 (7) ◽  
Author(s):  
Michela Dispinzieri ◽  
Eliana La Rocca ◽  
Elisabetta Meneghini ◽  
Alba Fiorentino ◽  
Laura Lozza ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Hormone Therapy ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
Breast Radiotherapy ◽  
Whole Breast Radiotherapy

De-escalation of breast radiotherapy after conserving surgery in low-risk early breast cancer patients

2018 ◽  
Vol 35 (5) ◽  
Author(s):  
Pierfrancesco Franco ◽  
Giuseppe Carlo Iorio ◽  
Sara Bartoncini ◽  
Mario Airoldi ◽  
Corrado De Sanctis ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Early Breast Cancer ◽  
Low Risk ◽  
Breast Cancer Patients ◽  
Breast Radiotherapy

scholarly journals Is prone free breathing better than supine deep inspiration breath-hold for left whole-breast radiotherapy? A dosimetric analysis

2021 ◽  
Author(s):  
Xinzhuo Wang ◽  
Odile Fargier-Bochaton ◽  
Giovanna Dipasquale ◽  
Mohamed Laouiti ◽  
Melpomeni Kountouri ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Free Breathing ◽  
Breath Hold ◽  
Deep Inspiration ◽  
Breast Cancer Patients ◽  
Breast Radiotherapy ◽  
Deep Inspiration Breath Hold ◽  
Number Of Patients ◽  
Whole Breast Radiotherapy

Abstract Purpose The advantage of prone setup compared with supine for left-breast radiotherapy is controversial. We evaluate the dosimetric gain of prone setup and aim to identify predictors of the gain. Methods Left-sided breast cancer patients who had dual computed tomography (CT) planning in prone free breathing (FB) and supine deep inspiration breath-hold (DiBH) were retrospectively identified. Radiation doses to heart, lungs, breasts, and tumor bed were evaluated using the recently developed mean absolute dose deviation (MADD). MADD measures how widely the dose delivered to a structure deviates from a reference dose specified for the structure. A penalty score was computed for every treatment plan as a weighted sum of the MADDs normalized to the breast prescribed dose. Changes in penalty scores when switching from supine to prone were assessed by paired t-tests and by the number of patients with a reduction of the penalty score (i.e., gain). Robust linear regression and fractional polynomials were used to correlate patients’ characteristics and their respective penalty scores. Results Among 116 patients identified with dual CT planning, the prone setup, compared with supine, was associated with a dosimetric gain in 72 (62.1%, 95% CI: 52.6–70.9%). The most significant predictors of a gain with the prone setup were the breast depth prone/supine ratio (>1.6), breast depth difference (>31 mm), prone breast depth (>77 mm), and breast volume (>282 mL). Conclusion Prone compared with supine DiBH was associated with a dosimetric gain in 62.1% of our left-sided breast cancer patients. High pendulousness and moderately large breast predicted for the gain.

Sign in / Sign up

Export Citation Format

Share Document