SU-FF-T-427: Treatment Planning Comparison On Normal Tissue Complication Probability and Tumor Control Probability in the Preoperative Pelvic Irradiation for Rectal Cancer

2007 ◽  
Vol 34 (6Part14) ◽  
pp. 2500-2500
Author(s):  
K Chu ◽  
L Wang ◽  
L Chao ◽  
D Huang ◽  
C Hsiao ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Treatment Planning ◽  
Normal Tissue ◽  
Normal Tissue Complication Probability ◽  
Tumor Control ◽  
Tumor Control Probability ◽  
Pelvic Irradiation

A treatment planning system with new paradigms in the effectiveness and side-effect evaluation sections

2021 ◽  
Author(s):  
Terman Frometa-Castillo ◽  
Anil Pyakuryal ◽  
Ganesh Narayanasamy ◽  
Asghar Mesbahi
Keyword(s):  
Treatment Planning ◽  
Side Effect ◽  
Normal Tissue ◽  
External Beam Radiotherapy ◽  
Planning System ◽  
Treatment Planning System ◽  
Tumor Control ◽  
Tumor Control Probability ◽  
Computational Simulations ◽  
Linear Quadratic

Abstract Aim Academic dissemination of the “SMp treatment planning system (TPS)” for external beam radiotherapy, which has been developed as a software function that could meet the definition of a device with an entirely new intended use. This system will have new paradigms in the effectiveness and side-effect (S-E) evaluation sections, where tumor control probability (TCP) is calculated with computational simulations instead of current analytical TCP models; and S-E is evaluated with the normal tissue non-complication probability (NTCP0) methodology instead of standard NTCP one. Methods Use of probabilistic foundations in the NTCP0 methodologies; and computational simulations of the interactions of ionizing radiation with the tumor tissues in the radiation oncology treatments for the TCP calculations. Results The "TCPsim" and “NTCP0cal” calculation modules of the SMp TPS, which calculate respectively TCP and NTCP0. Conclusions While the "NTCP0cal" application has unquestionable probabilistic foundations associated to normal tissue complications as a stochastic process with more than one outcome; the "TCPsim" is based on proper approaches that are result of the computational simulations that follow logic-probabilistic procedures, and probabilistic aspects, like the relationship between TCP and linear-quadratic cell survival model for a fraction with dose d.

scholarly journals Similar-Case-Based Optimization of Beam Arrangements in Stereotactic Body Radiotherapy for Assisting Treatment Planners

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Taiki Magome ◽  
Hidetaka Arimura ◽  
Yoshiyuki Shioyama ◽  
Katsumasa Nakamura ◽  
Hiroshi Honda ◽  
...  
Keyword(s):  
Treatment Planning ◽  
Stereotactic Body Radiotherapy ◽  
Similar Case ◽  
Organs At Risk ◽  
Normal Tissue Complication Probability ◽  
Radiation Absorption ◽  
Conformity Index ◽  
Tumor Control ◽  
Tumor Control Probability ◽  
Case Based

Objective. To develop a similar-case-based optimization method for beam arrangements in lung stereotactic body radiotherapy (SBRT) to assist treatment planners.Methods. First, cases that are similar to an objective case were automatically selected based on geometrical features related to a planning target volume (PTV) location, PTV shape, lung size, and spinal cord position. Second, initial beam arrangements were determined by registration of similar cases with the objective case using a linear registration technique. Finally, beam directions of the objective case were locally optimized based on the cost function, which takes into account the radiation absorption in normal tissues and organs at risk. The proposed method was evaluated with 10 test cases and a treatment planning database including 81 cases, by using 11 planning evaluation indices such as tumor control probability and normal tissue complication probability (NTCP).Results. The procedure for the local optimization of beam arrangements improved the quality of treatment plans with significant differences (P<0.05) in the homogeneity index and conformity index for the PTV, V10, V20, mean dose, and NTCP for the lung.Conclusion. The proposed method could be usable as a computer-aided treatment planning tool for the determination of beam arrangements in SBRT.

scholarly journals Planejamento tridimensional para radioterapia de tumores de esôfago: comparação de técnicas de tratamento e análise de probabilidade de complicações

2003 ◽  
Vol 36 (3) ◽  
pp. 157-162 ◽  
Author(s):  
Pitágoras Báskara Justino ◽  
Heloisa de Andrade Carvalho ◽  
Débora Ferauche ◽  
Renato Ros
Keyword(s):  
Normal Tissue ◽  
Normal Tissue Complication Probability ◽  
Tumor Control ◽  
Tumor Control Probability ◽  
Dose Volume ◽  
Cáncer De Esófago

Para comparar diversas técnicas de irradiação para o câncer de esôfago, foi utilizado sistema de planejamento tridimensional. Em um paciente com carcinoma espinocelular de esôfago médio, foram estudadas as seguintes técnicas de tratamento: dois campos ântero-posteriores e dois campos látero-laterais paralelos e opostos, três campos em "Y" e em "T" e quatro campos em "X". Foram obtidos os histogramas dose-volume, considerando como órgãos de risco medula espinhal e pulmões. Os resultados foram analisados de acordo com as recomendações da Normal Tissue Complication Probability (NTCP) e Tumor Control Probability (TCP). Quanto às doses de irradiação em pulmão, a melhor opção foi a técnica em dois campos ântero-posteriores paralelos e opostos. A medula foi mais poupada quando se utilizaram campos látero-laterais. Sugerimos a combinação de pelo menos duas técnicas de tratamento: ântero-posterior e as técnicas com campos em "Y", "T" ou látero-laterais, para o balanceamento das doses em pulmões e medula espinhal. Ou, ainda, a utilização de técnicas de três campos durante todo o tratamento.

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