Tumor control probability and normal tissue complication probability models based on generalized equivalent uniform dose formalism

2004 ◽  
Vol 60 (1) ◽  
pp. S584-S585
Author(s):  
S. Zhou ◽  
S. Das ◽  
Z. Wang ◽  
L. Marks ◽  
X. Sun
Keyword(s):  
Normal Tissue ◽  
Normal Tissue Complication Probability ◽  
Tumor Control ◽  
Tumor Control Probability ◽  
Probability Models ◽  
Equivalent Uniform Dose

Self-consistent tumor control probability and normal tissue complication probability models based on generalized EUDa)

2007 ◽  
Vol 34 (7) ◽  
pp. 2807-2815 ◽  
Author(s):  
Su-Min Zhou ◽  
Shiva K. Das ◽  
Zhiheng Wang ◽  
Xuejun Sun ◽  
Mark Dewhirst ◽  
...  
Keyword(s):  
Normal Tissue ◽  
Normal Tissue Complication Probability ◽  
Tumor Control ◽  
Tumor Control Probability ◽  
Probability Models ◽  
Self Consistent

scholarly journals A Brachytherapy Plan Evaluation Tool for Interstitial Applications

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Surega Anbumani ◽  
N. Arunai Nambiraj ◽  
Sridhar Dayalan ◽  
Kalaivany Ganesh ◽  
Pichandi Anchineyan ◽  
...  
Keyword(s):  
Normal Tissue ◽  
Treatment Plan ◽  
Predictive Ability ◽  
Normal Tissue Complication Probability ◽  
Tumor Control ◽  
Tumor Control Probability ◽  
Evaluation Tool ◽  
Equivalent Uniform Dose ◽  
Plan Evaluation ◽  
Dose Volume Histograms

Radiobiological metrics such as tumor control probability (TCP) and normal tissue complication probability (NTCP) help in assessing the quality of brachytherapy plans. Application of such metrics in clinics as well as research is still inadequate. This study presents the implementation of two indigenously designed plan evaluation modules: Brachy_TCP and Brachy_NTCP. Evaluation tools were constructed to compute TCP and NTCP from dose volume histograms (DVHs) of any interstitial brachytherapy treatment plan. The computation module was employed to estimate probabilities of tumor control and normal tissue complications in ten cervical cancer patients based on biologically effective equivalent uniform dose (BEEUD). The tumor control and normal tissue morbidity were assessed with clinical followup and were scored. The acute toxicity was graded using common terminology criteria for adverse events (CTCAE) version 4.0. Outcome score was found to be correlated with the TCP/NTCP estimates. Thus, the predictive ability of the estimates was quantified with the clinical outcomes. Biologically effective equivalent uniform dose-based formalism was found to be effective in predicting the complexities and disease control.

scholarly journals Evaluation of the radiobiological gamma index with motion interplay in tangential IMRT breast treatment

2016 ◽  
Vol 57 (6) ◽  
pp. 691-701 ◽  
Author(s):  
Iori Sumida ◽  
Hajime Yamaguchi ◽  
Indra J. Das ◽  
Hisao Kizaki ◽  
Keiko Aboshi ◽  
...  
Keyword(s):  
Early Stage ◽  
Organs At Risk ◽  
Intensity Modulated Radiation Therapy ◽  
Target Volume ◽  
Normal Tissue Complication Probability ◽  
Tumor Control ◽  
Tumor Control Probability ◽  
Equivalent Uniform Dose ◽  
Gamma Index ◽  
The Impact

Abstract The purpose of this study was to evaluate the impact of the motion interplay effect in early-stage left-sided breast cancer intensity-modulated radiation therapy (IMRT), incorporating the radiobiological gamma index (RGI). The IMRT dosimetry for various breathing amplitudes and cycles was investigated in 10 patients. The predicted dose was calculated using the convolution of segmented measured doses. The physical gamma index (PGI) of the planning target volume (PTV) and the organs at risk (OAR) was calculated by comparing the original with the predicted dose distributions. The RGI was calculated from the PGI using the tumor control probability (TCP) and the normal tissue complication probability (NTCP). The predicted mean dose and the generalized equivalent uniform dose (gEUD) to the target with various breathing amplitudes were lower than the original dose (P < 0.01). The predicted mean dose and gEUD to the OARs with motion were higher than for the original dose to the OARs (P < 0.01). However, the predicted data did not differ significantly between the various breathing cycles for either the PTV or the OARs. The mean RGI gamma passing rate for the PTV was higher than that for the PGI (P < 0.01), and for OARs, the RGI values were higher than those for the PGI (P < 0.01). The gamma passing rates of the RGI for the target and the OARs other than the contralateral lung differed significantly from those of the PGI under organ motion. Provided an NTCP value <0.05 is considered acceptable, it may be possible, by taking breathing motion into consideration, to escalate the dose to achieve the PTV coverage without compromising the TCP.

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