Experimental Therapies Of Human Pancreatic Carcinoma Transplanted To Nude Mice - A Study On Photodynamic Therapy And Local Interstitial Hyperthermia Using Low Power Nd:YAG Laser

1987 ◽  
Author(s):  
Hisao Tajiri ◽  
Daizo Saito ◽  
Yanao Oguro ◽  
Norio Daikuzono ◽  
Stephen N. Joffe ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Low Power ◽  
Pancreatic Carcinoma ◽  
Nude Mice ◽  
Nd:Yag Laser ◽  
Interstitial Hyperthermia ◽  
Experimental Therapies

Photodynamic Therapy-Induced Rapid Cell Death by Apoptosis in Human Pancreatic Carcinoma Transplanted into Nude Mice.

1996 ◽  
Vol 21 (1) ◽  
pp. 29-37 ◽  
Author(s):  
Hisao TAJIRI ◽  
Nariyoshi SHINOMIYA ◽  
Akemi HAYAKAWA ◽  
Yoshinari MATSUMOTO ◽  
Shigeaki YOSHIDA
Keyword(s):  
Cell Death ◽  
Photodynamic Therapy ◽  
Pancreatic Carcinoma ◽  
Nude Mice

Interstitial Hyperthermia Treatment Using Nd:YAG Laser

1989 ◽  
Author(s):  
Masoud Panjehpour ◽  
Andrew J. Milligan ◽  
Bergein F. Overholt
Keyword(s):  
Nd:Yag Laser ◽  
Hyperthermia Treatment ◽  
Interstitial Hyperthermia

scholarly journals Sensitization of cerebral tissue in nude mice with photodynamic therapy induces ADAM17/TACE and promotes glioma cell invasion

2008 ◽  
Vol 265 (2) ◽  
pp. 177-187 ◽  
Author(s):  
Xuguang Zheng ◽  
Feng Jiang ◽  
Mark Katakowski ◽  
Xuepeng Zhang ◽  
Hao Jiang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Nude Mice ◽  
Cell Invasion ◽  
Glioma Cell ◽  
Cerebral Tissue

Low-dose photodynamic therapy increases endothelial cell proliferation and VEGF expression in nude mice brain

2005 ◽  
Vol 20 (2) ◽  
pp. 74-79 ◽  
Author(s):  
Xuepeng Zhang ◽  
Feng Jiang ◽  
Zheng Gang Zhang ◽  
Steven N Kalkanis ◽  
Xin Hong ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Photodynamic Therapy ◽  
Endothelial Cell ◽  
Nude Mice ◽  
Low Dose ◽  
Endothelial Cell Proliferation ◽  
Vegf Expression ◽  
Mice Brain

Topical Administration of Tetrasodium-Mesotetraphenyl-Porphinesulfonate (TPPS): Correlation between Drug Penetration and Depth of Necrosis in Skin of Nude Mice following Red Light Irradiation

1987 ◽  
Vol 73 (1) ◽  
pp. 11-17 ◽  
Author(s):  
Renato Marchesini ◽  
Elsa Melloni ◽  
Giovanni Bottiroli ◽  
Salvatore Andreola ◽  
Giannino Fava ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Nude Mice ◽  
Red Light ◽  
Local Treatment ◽  
Topical Administration ◽  
Skin Lesions ◽  
Drug Penetration ◽  
Suitable Treatment ◽  
Epithelial Layers ◽  
Photosensitizing Agent

The main side effect in photodynamic therapy is photosensitization of the patient's skin following systemic administration of the photosensitizing agent. In the case of superficial lesions, this problem can be avoided by topically applying the drug: in this way a local treatment can be performed. We tested the photosensitizing properties of a 2 % solution of TPPS (tetrasodium-tetraphenylporphinesulfonate) in a vehicle containing a penetration enhancer, Azone, on skin of nude mice. An aliquot of 0.1 ml/cm2 of the solution was painted on the skin overlying an s.c. implanted NMU-1 tumor. Subsequently, animals were sacrificed at different times after application. Fluorescence microscopy revealed that TPPS penetration depth was related to time elapsed after application and to painting modalities. Solution penetration was enhanced by wiping with ether immediately before painting. Irradiation at 80 mW/cm2 for 20 min with a dye laser emitting at 640 am, 4 h after TPPS application, produced necrosis of the upper skin layers, up to 0.2 mm in depth. These findings suggest that topical TPPS administration, followed by laser irradiation, may be a suitable treatment modality for skin lesions involving epithelial layers, even though several aspects of this metodology need further investigation.

Sign in / Sign up

Export Citation Format

Share Document