Individual in-vitro sensitivities of human pancreatic carcinoma cell lines to photodynamic therapy

1992 ◽  
Author(s):  
K. T. Moesta ◽  
Andrew Dmytrijuk ◽  
Peter M. Schlag ◽  
Thomas S. Mang
Keyword(s):  
Photodynamic Therapy ◽  
Pancreatic Carcinoma ◽  
Cell Lines ◽  
Carcinoma Cell ◽  
Carcinoma Cell Lines ◽  
Human Pancreatic Carcinoma Cell

Newly established human pancreatic carcinoma cell lines and their lectin binding properties

1993 ◽  
Vol 13 (1) ◽  
pp. 31-41
Author(s):  
Nobuyuki Nishimura ◽  
Seiji Saito ◽  
Yoshiki Kubota ◽  
Nan-yo Moto-o ◽  
Kuniko Taguchi ◽  
...  
Keyword(s):  
Pancreatic Carcinoma ◽  
Cell Lines ◽  
Carcinoma Cell ◽  
Lectin Binding ◽  
Binding Properties ◽  
Carcinoma Cell Lines ◽  
Human Pancreatic Carcinoma Cell

ATP-Binding Cassette C Transporters in Human Pancreatic Carcinoma Cell Lines

Pancreatology ◽  
2009 ◽  
Vol 9 (1-2) ◽  
pp. 136-144 ◽  
Author(s):  
Wolfgang Hagmann ◽  
Ralf Jesnowski ◽  
Ralf Faissner ◽  
Changqing Guo ◽  
J. Matthias Löhr
Keyword(s):  
Pancreatic Carcinoma ◽  
Cell Lines ◽  
Carcinoma Cell ◽  
Atp Binding ◽  
Carcinoma Cell Lines ◽  
Human Pancreatic Carcinoma Cell ◽  
Atp Binding Cassette

Expression of and Response to Growth Regulatory Peptides by Two Human Pancreatic Carcinoma Cell Lines

Pancreas ◽  
1990 ◽  
Vol 5 (4) ◽  
pp. 369-380 ◽  
Author(s):  
R. Daniel Beauchamp ◽  
Russette M. Lyons ◽  
Edmund Y. Yang ◽  
Robert J. Coffey ◽  
Harold L. Moses
Keyword(s):  
Pancreatic Carcinoma ◽  
Cell Lines ◽  
Carcinoma Cell ◽  
Regulatory Peptides ◽  
Carcinoma Cell Lines ◽  
Human Pancreatic Carcinoma Cell

Presence of survivin-specific cytotoxic T-lymphocytes (CTLs) in pancreatic cancer patients, and specific killing of human pancreatic carcinoma cells in vitro by survivin-specific CTLs

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 3070-3070
Author(s):  
D. Z. Chang ◽  
K. Zhu ◽  
S. Kopetz ◽  
K. Voo ◽  
Y. Li ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
T Lymphocytes ◽  
Pancreatic Carcinoma ◽  
Cell Lines ◽  
Cytotoxic T Lymphocytes ◽  
Carcinoma Cell ◽  
Specific Ctls ◽  
Carcinoma Cell Lines ◽  
Ifn Γ

3070 Background: The apoptosis inhibitor protein Survivin is an attractive target for a cancer vaccine because of its differential overexpression by most human tumors, its importance for tumor survival, and its demonstrated immunogenicity. To examine Survivin’s potential as a vaccine target for pancreatic cancer (PC), we evaluated the presence of Survivin-specific cytotoxic T-lymphocytes (CTLs) in PC patients and assessed the specific killing of HLA-A*0201+ human pancreatic carcinoma cell lines in vitro by Survivin-specific CTL. Methods: Mononuclear cells from the peripheral blood (PBMC) of PC patients and normal donors and Survivin peptides were used to generate Survivin-specific CTLs in vitro. The presence of Survivin-specific CTLs was evaluated by IFN-γ ELISPOT analysis. Recognition of human PC cell lines (e.g., Panc-1 and CF-Pac-1) was analyzed by 51Cr release assays. Results: Multiple CTL lines were generated from different donors against a number of Survivin 9-mer and 10-mer peptides, including Sur5–14, Sur95–104, and Sur96–104 and altered forms of these peptides with enhanced HLA-A*0201 binding. Sur5–14 (TLPPAWQPFL) and new modified mSur95–104 (ELMLGEFLKL) peptides could generate specific CTL from the PBMC of most donors, and the resulting CTL showed cytotoxicity against Survivin peptide-pulsed Panc-1 and CF-Pac-1 in an HLA-A2-dependent manner. We found for the first time that mSur95–104 could elicit CTL activity that cross-reacted with wild-type peptide and 9-mer Sur96–104 in IFN-γ ELISPOT assays. In our preliminary analysis, we detected Survivin peptide-specific CTLs in four of five PC patients for Sur5–14 and three of five for mSur95–104. All five PC patients had a positive response to a pool of A2 peptides as positive controls, indicating their immune competence. Conclusions: CTLs specific for human Survivin peptide Sur5–14 and the modified peptides mSur95–104 were detected in majority of the PC patients tested. Further, Survivin-specific CTLs killed pancreatic carcinoma cell lines in vitro. Our results suggest that these two peptides are potential vaccines for the treatment of PC. No significant financial relationships to disclose.

Study of the development of thermoresistance in human pancreatic carcinoma cell lines using proteome analysis

2004 ◽  
Vol 25 (1) ◽  
pp. 173-183 ◽  
Author(s):  
Julia Poland ◽  
Andrea Urbani ◽  
Hermann Lage ◽  
Martina Schnölzer ◽  
Pranav Sinha
Keyword(s):  
Pancreatic Carcinoma ◽  
Cell Lines ◽  
Carcinoma Cell ◽  
Proteome Analysis ◽  
Carcinoma Cell Lines ◽  
Human Pancreatic Carcinoma Cell

Retinoids: Effects on growth, differentiation, and nuclear receptor expression in human pancreatic carcinoma cell lines

1995 ◽  
Vol 109 (5) ◽  
pp. 1646-1660 ◽  
Author(s):  
Stefan Rosewicz ◽  
Ute Stier ◽  
Felix Brembeck ◽  
Astrid Kaiser ◽  
Christos A. Papadimitriou ◽  
...  
Keyword(s):  
Pancreatic Carcinoma ◽  
Cell Lines ◽  
Nuclear Receptor ◽  
Carcinoma Cell ◽  
Receptor Expression ◽  
Carcinoma Cell Lines ◽  
Human Pancreatic Carcinoma Cell

Establishment and characterization of four human pancreatic carcinoma cell lines

2002 ◽  
Vol 308 (2) ◽  
pp. 205-214 ◽  
Author(s):  
Ja-Lok Ku ◽  
Kyong-Ah Yoon ◽  
Woo-Ho Kim ◽  
Jin Jang ◽  
Kyung-Suk Suh ◽  
...  
Keyword(s):  
Pancreatic Carcinoma ◽  
Cell Lines ◽  
Carcinoma Cell ◽  
Carcinoma Cell Lines ◽  
Human Pancreatic Carcinoma Cell
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