Initial study of breast tissue retraction toward image guided breast surgery

2012 ◽  
Author(s):  
Michael J. Shannon ◽  
Ingrid M. Meszoely ◽  
Janet E. Ondrake ◽  
Thomas S. Pheiffer ◽  
Amber L. Simpson ◽  
...  
Keyword(s):  
Breast Tissue ◽  
Breast Surgery ◽  
Initial Study ◽  
Image Guided

Image-guided photoacoustic spectroscopy in diagnosis of osteoarthritis in hands: an initial study

2011 ◽  
Author(s):  
Zhen Yuan ◽  
J. Xiao ◽  
Yao Sun ◽  
Eric S. Sobel ◽  
Jishan He ◽  
...  
Keyword(s):  
Photoacoustic Spectroscopy ◽  
Initial Study ◽  
Image Guided

Image-guided breast surgery

2005 ◽  
Vol 190 (2) ◽  
pp. 221-227 ◽  
Author(s):  
Jacobo Nurko ◽  
Michael J. Edwards
Keyword(s):  
Breast Surgery ◽  
Image Guided

scholarly journals A multicentre observational study evaluating image-guided radiotherapy for more accurate partial-breast intensity-modulated radiotherapy: comparison with standard imaging technique

2014 ◽  
Vol 1 (3) ◽  
pp. 1-74 ◽  
Author(s):  
Emma J Harris ◽  
Mukesh Mukesh ◽  
Rajesh Jena ◽  
Angela Baker ◽  
Harry Bartelink ◽  
...  
Keyword(s):  
Normal Tissue ◽  
Breast Tissue ◽  
Imaging Technique ◽  
Probability Model ◽  
Breast Radiotherapy ◽  
Image Guided Radiotherapy ◽  
Image Guided ◽  
Safety Margins ◽  
Integrated Boost ◽  
Set Up

BackgroundWhole-breast radiotherapy (WBRT) is the standard treatment for breast cancer following breast-conserving surgery. Evidence shows that tumour recurrences occur near the original cancer: the tumour bed. New treatment developments include increasing dose to the tumour bed during WBRT (synchronous integrated boost) and irradiating only the region around the tumour bed, for patients at high and low risk of tumour recurrence, respectively. Currently, standard imaging uses bony anatomy to ensure accurate delivery of WBRT. It is debatable whether or not more targeted treatments such as synchronous integrated boost and partial-breast radiotherapy require image-guided radiotherapy (IGRT) focusing on implanted tumour bed clips (clip-based IGRT).ObjectivesPrimary – to compare accuracy of patient set-up using standard imaging compared with clip-based IGRT. Secondary – comparison of imaging techniques using (1) tumour bed radiotherapy safety margins, (2) volume of breast tissue irradiated around tumour bed, (3) estimated breast toxicity following development of a normal tissue control probability model and (4) time taken.DesignMulticentre observational study embedded within a national randomised trial: IMPORT-HIGH (Intensity Modulated and Partial Organ Radiotherapy – HIGHer-risk patient group) testing synchronous integrated boost and using clip-based IGRT.SettingFive radiotherapy departments, participating in IMPORT-HIGH.ParticipantsTwo-hundred and eighteen patients receiving breast radiotherapy within IMPORT-HIGH.InterventionsThere was no direct intervention in patients’ treatment. Experimental and control intervention were clip-based IGRT and standard imaging, respectively. IMPORT-HIGH patients received clip-based IGRT as routine; standard imaging data were obtained from clip-based IGRT images.Main outcome measuresDifference in (1) set-up errors, (2) safety margins, (3) volume of breast tissue irradiated, (4) breast toxicity and (5) time, between clip-based IGRT and standard imaging.ResultsThe primary outcome of overall mean difference in clip-based IGRT and standard imaging using daily set-up errors was 2–2.6 mm (p < 0.001). Heterogeneity testing between centres found a statistically significant difference in set-up errors at one centre. For four centres (179 patients), clip-based IGRT gave a mean decrease in the systematic set-up error of between 1 mm and 2 mm compared with standard imaging. Secondary outcomes were as follows: clip-based IGRT and standard imaging safety margins were less than 5 mm and 8 mm, respectively. Using clip-based IGRT, the median volume of tissue receiving 95% of prescribed boost dose decreased by 29 cm3(range 11–193 cm3) compared with standard imaging. Difference in median time required to perform clip-based IGRT compared with standard imaging was X-ray imaging technique dependent (range 8–76 seconds). It was not possible to estimate differences in breast toxicity, the normal tissue control probability model indicated that for breast fibrosis maximum radiotherapy dose is more important than volume of tissue irradiated.Conclusions and implications for clinical practiceMargins of less than 8 mm cannot be used safely without clip-based IGRT for patients receiving concomitant tumour bed boost, as there is a risk of geographical miss of the tumour bed being treated. In principle, smaller but accurately placed margins may influence local control and toxicity rates, but this needs to be evaluated from mature clinical trial data in the future.FundingThe National Institute for Health Research Efficacy and Mechanism Evaluation programme.

scholarly journals Charcoal granuloma mimicking breast cancer: an emerging diagnosis

2018 ◽  
Vol 7 (12) ◽  
pp. 205846011881572
Author(s):  
Gabriel Lucca de Oliveira Salvador ◽  
Poliana Palma Barbieri ◽  
Laura Maschke ◽  
Anna Luisa Aranha Nunes ◽  
Maria Helena Louveira ◽  
...  
Keyword(s):  
Breast Tissue ◽  
Breast Lesion ◽  
Preoperative Localization ◽  
Histopathological Analysis ◽  
Resonance Imaging ◽  
Imaging Studies ◽  
Ultrasound Guided ◽  
Image Guided ◽  
Malignant Lesions

Background Image-guided charcoal injection in suspicious breast lesions for preoperative localization is a procedure that has been increasing over the years because it is safer, faster, and more affordable when compared to needle-wire preoperative localization. To date, no complications have been associated with the method. However, in recent years there have been some reports about charcoal granulomas mimicking malignant lesions in some postoperative patients or in a conservative follow-up. Purpose To report a series of 11 cases which had suspicious imaging findings for malignancy and resulted in charcoal granulomas on histopathological analysis. Material and Methods A database of 1650 patients that attended our center from January 2007 to June 2018 was reviewed and detected 495 patients who had been previously submitted to ultrasound-guided charcoal marking in a breast lesion. Then, patients whose imaging studies were compatible with new suspicious lesions on mammography, breast ultrasound, and/or magnetic resonance imaging and biopsy of this new lesion indicating charcoal granuloma were selected. Results From 495 patients who had undergone charcoal localization injections in previous biopsies, we selected 11 who had new lesions with malignant characteristics on imaging studies but histopathological analysis resulted in charcoal granuloma. Conclusion Charcoal granuloma should be considered in patients with previous preoperative injection localization, since the residual charcoal in the breast tissue may form granulomas and mimic malignant lesions on follow-up imaging studies.

scholarly journals Image guided near-infrared spectroscopy of breast tissue in vivo using boundary element method

2010 ◽  
Vol 15 (6) ◽  
pp. 061703 ◽  
Author(s):  
Subhadra Srinivasan ◽  
Colin M. Carpenter ◽  
Hamid R. Ghadyani ◽  
Senate J. Taka ◽  
Peter A. Kaufman ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Boundary Element Method ◽  
Boundary Element ◽  
Near Infrared Spectroscopy ◽  
Breast Tissue ◽  
Near Infrared ◽  
Image Guided ◽  
Element Method

scholarly journals Endoscopic Excision of A Fibroadenoma Breast: Trans Axillary Approach

2013 ◽  
Vol 10 (2) ◽  
pp. 106-108 ◽  
Author(s):  
S Adhikary ◽  
S Sood ◽  
K Dunghel ◽  
S Rajbanshi ◽  
V Shakya ◽  
...  
Keyword(s):  
Medical Journal ◽  
Breast Tissue ◽  
Breast Surgery ◽  
Surgical Excision ◽  
Minimal Invasive ◽  
Easy Access ◽  
Axillary Approach ◽  
Breast Lumps ◽  
Anatomical Space ◽  
Endoscopic Breast Surgery

Benign breast lumps affect 10% of females in their lifetime. Surveillance, assurance, medications and surgical excision are options available to surgeons. Avoiding scars on the breast is an inherent feminine desire. Numerous minimal invasive approaches have evolved due to this concern. The time honoured circumareolar incisions camouflages the scar to a large extent, yet the incision still remains on the breast tissue and unfortunately the scar undergoes the same old sequelae as with any other scars both aesthetically or psychosocially. The close by anatomical space; axilla provides an easy access for endoscopic breast surgery. We utilized this area and applied our expertise to remove a fibroadenoma in a teenager which spared her breast from the scar. The technique was safe and effective. It conserved aesthetics and led to a better compliance. Kathmandu University Medical Journal | Vol.10 | No. 2 | Issue 38 | Apr – June 2012 | Page 106-108 DOI: http://dx.doi.org/10.3126/kumj.v10i2.7357

scholarly journals Evaluation of EphB4 as Target for Image-Guided Surgery of Breast Cancer

2020 ◽  
Vol 13 (8) ◽  
pp. 172
Author(s):  
Cansu de Muijnck ◽  
Yoren van Gorkom ◽  
Maurice van Duijvenvoorde ◽  
Mina Eghtesadi ◽  
Geeske Dekker-Ensink ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tyrosine Kinase ◽  
Breast Tissue ◽  
Normal Breast Tissue ◽  
Normal Breast ◽  
Her2 Status ◽  
Image Guided Surgery ◽  
Tyrosine Kinase Receptor ◽  
Guided Surgery ◽  
Image Guided

Background: Targeted image-guided surgery is based on the detection of tumor cells after administration of a radio-active or fluorescent tracer. Hence, enhanced binding of a tracer to tumor tissue compared to healthy tissue is crucial. Various tumor antigens have been evaluated as possible targets for image-guided surgery of breast cancer, with mixed results. Methods: In this study we have evaluated tyrosine kinase receptor EphB4, a member from the Eph tyrosine kinase receptor family, as a possible target for image-guided surgery of breast cancers. Two independent tissue micro arrays, consisting of matched sets of tumor and normal breast tissue, were stained for EphB4 by immunohistochemistry. The intensity of staining and the percentage of stained cells were scored by two independent investigators. Results: Immunohistochemical staining for EphB4 shows that breast cancer cells display enhanced membranous expression compared to adjacent normal breast tissue. The enhanced tumor staining is not associated with clinical variables like age of the patient or stage or subtype of the tumor, including Her2-status. Conclusion: These data suggest that EphB4 is a promising candidate for targeted image-guided surgery of breast cancer, especially for Her2 negative cases.

201. A voice for sentinel node biopsy at the time of breast surgery for non-palpable but mass-forming pure DCIS found on image-guided breast biopsy

2016 ◽  
Vol 42 (9) ◽  
pp. S120
Author(s):  
B. Szynglarewicz ◽  
P. Kasprzak ◽  
A. Maciejczyk ◽  
T. Michalik ◽  
B. Oleszkiewicz ◽  
...  
Keyword(s):  
Sentinel Node ◽  
Sentinel Node Biopsy ◽  
Breast Biopsy ◽  
Breast Surgery ◽  
Image Guided ◽  
Node Biopsy

Image to physical space registration of supine breast MRI for image guided breast surgery

2014 ◽  
Author(s):  
Rebekah H. Conley ◽  
Ingrid M. Meszoely ◽  
Thomas S. Pheiffer ◽  
Jared A. Weis ◽  
Thomas E. Yankeelov ◽  
...  
Keyword(s):  
Breast Surgery ◽  
Physical Space ◽  
Breast Mri ◽  
Image Guided
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