scholarly journals Optical coherence microscopy for deep tissue imaging of the cerebral cortex with intrinsic contrast

2012 ◽  
Author(s):  
Vivek J. Srinivasan ◽  
Harsha Radhakrishnan ◽  
James Y. Jiang ◽  
Scott Barry ◽  
Alex E. Cable
Keyword(s):  
Cerebral Cortex ◽  
Tissue Imaging ◽  
Optical Coherence ◽  
Deep Tissue ◽  
Optical Coherence Microscopy ◽  
Deep Tissue Imaging

scholarly journals Optical coherence microscopy for deep tissue imaging of the cerebral cortex with intrinsic contrast

2012 ◽  
Vol 20 (3) ◽  
pp. 2220 ◽  
Author(s):  
Vivek J. Srinivasan ◽  
Harsha Radhakrishnan ◽  
James Y. Jiang ◽  
Scott Barry ◽  
Alex E. Cable
Keyword(s):  
Cerebral Cortex ◽  
Tissue Imaging ◽  
Optical Coherence ◽  
Deep Tissue ◽  
Optical Coherence Microscopy ◽  
Deep Tissue Imaging

scholarly journals Signal-to-background ratio and lateral resolution in deep tissue imaging by optical coherence microscopy in the 1700 nm spectral band

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Masahito Yamanaka ◽  
Naoki Hayakawa ◽  
Norihiko Nishizawa
Keyword(s):  
Spectral Band ◽  
Lateral Resolution ◽  
Tissue Imaging ◽  
Optical Coherence ◽  
Deep Tissue ◽  
Optical Coherence Microscopy ◽  
Background Ratio ◽  
Tissue Phantom ◽  
En Face ◽  
Deep Tissue Imaging

Abstract We quantitatively investigated the image quality in deep tissue imaging with optical coherence microscopy (OCM) in the 1700 nm spectral band, in terms of the signal-to-background ratio (SBR) and lateral resolution. In this work, to demonstrate the benefits of using the 1700 nm spectral band for OCM imaging of brain samples, we compared the imaging quality of OCM en-face images obtained at the same position by using a hybrid 1300 nm/1700 nm spectral domain (SD) OCM system with shared sample and reference arms. By observing a reflective resolution test target through a 1.5 mm-thick tissue phantom, which had a similar scattering coefficient to brain cortex tissue, we confirmed that 1700 nm OCM achieved an SBR about 6-times higher than 1300 nm OCM, although the lateral resolution of the both OCMs was similarly degraded with the increase of the imaging depth. Finally, we also demonstrated high-contrast deep tissue imaging of a mouse brain at a depth up to 1.8 mm by using high-resolution 1700 nm SD-OCM.

scholarly journals Dual-axis optical coherence tomography for deep tissue imaging

2017 ◽  
Vol 42 (12) ◽  
pp. 2302 ◽  
Author(s):  
Yang Zhao ◽  
Will J. Eldridge ◽  
Jason R. Maher ◽  
Sanghoon Kim ◽  
Michael Crose ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Tissue Imaging ◽  
Optical Coherence ◽  
Deep Tissue ◽  
Deep Tissue Imaging
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