scholarly journals Optical coherence microscopy in 1700 nm spectral band for high-resolution label-free deep-tissue imaging

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Masahito Yamanaka ◽  
Tatsuhiro Teranishi ◽  
Hiroyuki Kawagoe ◽  
Norihiko Nishizawa
Keyword(s):  
High Resolution ◽  
Spectral Band ◽  
Tissue Imaging ◽  
Optical Coherence ◽  
Label Free ◽  
Deep Tissue ◽  
Optical Coherence Microscopy ◽  
Deep Tissue Imaging

scholarly journals Signal-to-background ratio and lateral resolution in deep tissue imaging by optical coherence microscopy in the 1700 nm spectral band

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Masahito Yamanaka ◽  
Naoki Hayakawa ◽  
Norihiko Nishizawa
Keyword(s):  
Spectral Band ◽  
Lateral Resolution ◽  
Tissue Imaging ◽  
Optical Coherence ◽  
Deep Tissue ◽  
Optical Coherence Microscopy ◽  
Background Ratio ◽  
Tissue Phantom ◽  
En Face ◽  
Deep Tissue Imaging

Abstract We quantitatively investigated the image quality in deep tissue imaging with optical coherence microscopy (OCM) in the 1700 nm spectral band, in terms of the signal-to-background ratio (SBR) and lateral resolution. In this work, to demonstrate the benefits of using the 1700 nm spectral band for OCM imaging of brain samples, we compared the imaging quality of OCM en-face images obtained at the same position by using a hybrid 1300 nm/1700 nm spectral domain (SD) OCM system with shared sample and reference arms. By observing a reflective resolution test target through a 1.5 mm-thick tissue phantom, which had a similar scattering coefficient to brain cortex tissue, we confirmed that 1700 nm OCM achieved an SBR about 6-times higher than 1300 nm OCM, although the lateral resolution of the both OCMs was similarly degraded with the increase of the imaging depth. Finally, we also demonstrated high-contrast deep tissue imaging of a mouse brain at a depth up to 1.8 mm by using high-resolution 1700 nm SD-OCM.

scholarly journals Optical coherence microscopy for deep tissue imaging of the cerebral cortex with intrinsic contrast

2012 ◽  
Vol 20 (3) ◽  
pp. 2220 ◽  
Author(s):  
Vivek J. Srinivasan ◽  
Harsha Radhakrishnan ◽  
James Y. Jiang ◽  
Scott Barry ◽  
Alex E. Cable
Keyword(s):  
Cerebral Cortex ◽  
Tissue Imaging ◽  
Optical Coherence ◽  
Deep Tissue ◽  
Optical Coherence Microscopy ◽  
Deep Tissue Imaging

scholarly journals Optical coherence microscopy for deep tissue imaging of the cerebral cortex with intrinsic contrast

2012 ◽  
Author(s):  
Vivek J. Srinivasan ◽  
Harsha Radhakrishnan ◽  
James Y. Jiang ◽  
Scott Barry ◽  
Alex E. Cable
Keyword(s):  
Cerebral Cortex ◽  
Tissue Imaging ◽  
Optical Coherence ◽  
Deep Tissue ◽  
Optical Coherence Microscopy ◽  
Deep Tissue Imaging

scholarly journals Ultrabright red AIEgens for two-photon vascular imaging with high resolution and deep penetration

2018 ◽  
Vol 9 (10) ◽  
pp. 2705-2710 ◽  
Author(s):  
Wei Qin ◽  
Pengfei Zhang ◽  
Hui Li ◽  
Jacky W. Y. Lam ◽  
Yuanjing Cai ◽  
...  
Keyword(s):  
High Resolution ◽  
Vascular Imaging ◽  
Tissue Imaging ◽  
Deep Penetration ◽  
High Contrast ◽  
Deep Tissue ◽  
Two Photon ◽  
High Penetration ◽  
Deep Tissue Imaging

A successful strategy for the design of ultrabright red luminogens with aggregation-induced emission (AIE) features is reported. The AIE dots can be utilized as efficient fluorescent probes for in vivo deep-tissue imaging with high penetration depth and high contrast.

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