Gaussian graphical modeling reveals specific lipid correlations in glioblastoma cells

2011 ◽  
Author(s):  
Nikola S. Mueller ◽  
Jan Krumsiek ◽  
Fabian J. Theis ◽  
Christian Böhm ◽  
Anke Meyer-Bäse
Keyword(s):  
Glioblastoma Cells ◽  
Graphical Modeling ◽  
Specific Lipid ◽  
Gaussian Graphical Modeling

scholarly journals Gaussian graphical modeling for spectrometric data analysis

2022 ◽  
pp. 107416
Author(s):  
Laura Codazzi ◽  
Alessandro Colombi ◽  
Matteo Gianella ◽  
Raffaele Argiento ◽  
Lucia Paci ◽  
...  
Keyword(s):  
Data Analysis ◽  
Graphical Modeling ◽  
Spectrometric Data ◽  
Gaussian Graphical Modeling

scholarly journals Robust sparse Gaussian graphical modeling

2017 ◽  
Vol 161 ◽  
pp. 172-190 ◽  
Author(s):  
Kei Hirose ◽  
Hironori Fujisawa ◽  
Jun Sese
Keyword(s):  
Graphical Modeling ◽  
Gaussian Graphical Modeling

scholarly journals Robust Gaussian Graphical Modeling Vial1Penalization

Biometrics ◽  
2012 ◽  
Vol 68 (4) ◽  
pp. 1197-1206 ◽  
Author(s):  
Hokeun Sun ◽  
Hongzhe Li
Keyword(s):  
Graphical Modeling ◽  
Gaussian Graphical Modeling

scholarly journals Gaussian graphical modeling reconstructs pathway reactions from high-throughput metabolomics data

2011 ◽  
Vol 5 (1) ◽  
pp. 21 ◽  
Author(s):  
Jan Krumsiek ◽  
Karsten Suhre ◽  
Thomas Illig ◽  
Jerzy Adamski ◽  
Fabian J Theis
Keyword(s):  
High Throughput ◽  
Metabolomics Data ◽  
Graphical Modeling ◽  
Gaussian Graphical Modeling

scholarly journals Robust Gaussian graphical modeling

2006 ◽  
Vol 97 (7) ◽  
pp. 1525-1550 ◽  
Author(s):  
Masashi Miyamura ◽  
Yutaka Kano
Keyword(s):  
Graphical Modeling ◽  
Gaussian Graphical Modeling

Deregulation of BCL2 family genes in glioblastoma cells consequent to poly(butyl cyanoacrylate) nanoparticles treatment

2019 ◽  
Vol 14 (10) ◽  
pp. 1102-1106
Author(s):  
Mahdieh Sadat Taghavi ◽  
Azim Akbarzadeh ◽  
Reza Mahdian
Keyword(s):  
Glioblastoma Cells ◽  
Bcl2 Family

Glioblastoma invasion and NMDA receptors: A novel prospect

2019 ◽  
Vol 106 (3) ◽  
pp. 250-260 ◽  
Author(s):  
DN Nandakumar ◽  
P Ramaswamy ◽  
C Prasad ◽  
D Srinivas ◽  
K Goswami
Keyword(s):  
Glutamate Receptors ◽  
Cell Lines ◽  
Intracellular Signaling ◽  
Transcript Level ◽  
Glioblastoma Cells ◽  
Invasion And Migration ◽  
Matrigel Invasion ◽  
Nmdar Activation ◽  
And Migration

Purpose Glioblastoma cells create glutamate-rich tumor microenvironment, which initiates activation of ion channels and modulates downstream intracellular signaling. N-methyl-D-aspartate receptors (NMDARs; a type of glutamate receptors) have a high affinity for glutamate. The role of NMDAR activation on invasion of glioblastoma cells and the crosstalk with α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) is yet to be explored. Main methods LN18, U251MG, and patient-derived glioblastoma cells were stimulated with NMDA to activate NMDAR glutamate receptors. The role of NMDAR activation on invasion and migration and its crosstalk with AMPAR were evaluated. Invasion and migration of glioblastoma cells were investigated by in vitro trans-well Matrigel invasion and trans-well migration assays, respectively. Expression of NMDARs and AMPARs at transcript level was evaluated by quantitative real-time polymerase chain reaction. Results We determined that NMDA stimulation leads to enhanced invasion in LN18, U251MG, and patient-derived glioblastoma cells, whereas inhibition of NMDAR using MK-801, a non-competitive antagonist of the NMDAR, significantly decreased the invasive capacity. Concordant with these findings, migration was significantly augmented by NMDAR in both cell lines. Furthermore, NMDA stimulation upregulated the expression of GluN2 and GluA1 subunits at the transcript level. Conclusions This study demonstrated the previously unexplored role of NMDAR in invasion of glioblastoma cells. Furthermore, the expression of the GluN2 subunit of NMDAR and the differential overexpression of the GluA1 subunit of AMPAR in both cell lines provide a plausible rationale of crosstalk between these calcium-permeable subunits in the glutamate-rich microenvironment of glioblastoma.

Sign in / Sign up

Export Citation Format

Share Document