Label-free 3D optical imaging of microcirculation within sentinel lymph node in vivo

2011 ◽  
Author(s):  
Yeongri Jung ◽  
Zhongwei Zhi ◽  
Ruikang K. Wang
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Optical Imaging ◽  
Label Free

scholarly journals Bright and stable near-infrared Pluronic–silica nanoparticles as contrast agents for in vivo optical imaging

2016 ◽  
Vol 4 (33) ◽  
pp. 5560-5566 ◽  
Author(s):  
Lesan Yan ◽  
Huiquan Wang ◽  
Anqi Zhang ◽  
Calvin Zhao ◽  
Yongping Chen ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Contrast Agents ◽  
Optical Imaging ◽  
Silica Nanoparticles ◽  
Near Infrared ◽  
Circulation Time ◽  
In Vivo Optical Imaging

The IR780@NPs exhibited excellent characteristics for in vivo imaging with a long circulation time and high retention in tumor and sentinel lymph node.

Facile scalable synthesis of highly monodisperse small silica nanoparticles using alkaline buffer solution and their application for efficient sentinel lymph node mapping

2017 ◽  
Vol 5 (3) ◽  
pp. 586-594 ◽  
Author(s):  
Bo Quan ◽  
Chaedong Lee ◽  
Jung Sun Yoo ◽  
Yuanzhe Piao
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Mapping ◽  
Buffer Solution ◽  
Diagnostic Efficacy ◽  
Lymph Node Mapping ◽  
Cancer Nanomedicine ◽  
Scalable Synthesis ◽  
Alkaline Buffer Solution

Cancer nanomedicine involving nanotechnology-based drugs and in vivo imaging agents is an active field of nanoscience that provides new ways of enhancing therapeutic and diagnostic efficacy.

scholarly journals TMTP1-modified Indocyanine Green-loaded Polymeric Micelles for Targeted Imaging of Cervical Cancer and Metastasis Sentinel Lymph Node in vivo

Theranostics ◽  
2019 ◽  
Vol 9 (24) ◽  
pp. 7325-7344 ◽  
Author(s):  
Rui Wei ◽  
Guiying Jiang ◽  
MengQin Lv ◽  
Songwei Tan ◽  
Xueqian Wang ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Indocyanine Green ◽  
Polymeric Micelles ◽  
Targeted Imaging

scholarly journals Novel bright-emission small-molecule NIR-II fluorophores for in vivo tumor imaging and image-guided surgery

2017 ◽  
Vol 8 (5) ◽  
pp. 3489-3493 ◽  
Author(s):  
Yao Sun ◽  
Mingmin Ding ◽  
Xiaodong Zeng ◽  
Yuling Xiao ◽  
Huaping Wu ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Small Molecule ◽  
Tumor Imaging ◽  
Image Guided Surgery ◽  
Guided Surgery ◽  
Image Guided ◽  
Bright Emission

This work presents the establishment of novel bright-emission small-molecule NIR-II fluorophores forin vivotumor imaging and NIR-II image-guided sentinel lymph node surgery.

In vivo evaluation of three different 99mTc-labelled radiopharmaceuticals for sentinel lymph node identification

2001 ◽  
Vol 22 (5) ◽  
pp. 499-504 ◽  
Author(s):  
M. M. EDREIRA ◽  
L. L. COLOMBO ◽  
J. H. PEREZ ◽  
E. O. SAJAROFF ◽  
S. G. de CASTIGLIA
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
In Vivo Evaluation ◽  
Sentinel Lymph Node Identification

SPIO requirements for in vivo sentinel lymph node localization

2015 ◽  
Author(s):  
S. Waanders ◽  
M. Ahmed ◽  
B. Anninga ◽  
R. M. Ferguson ◽  
A. P. Khandhar ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Node Localization

scholarly journals Comparative Study of a Series of 99mTc(CO)3 Mannosylated Dextran Derivatives for Sentinel Lymph Node Detection

Molecules ◽  
2021 ◽  
Vol 26 (16) ◽  
pp. 4797
Author(s):  
Afroditi Papasavva ◽  
Antonio Shegani ◽  
Christos Kiritsis ◽  
Ioanna Roupa ◽  
Myrto Ischyropoulou ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Radiochemical Yield ◽  
Sentinel Lymph Node Detection ◽  
Imaging Studies ◽  
Nmr Techniques ◽  
High Yields ◽  
Mannose Receptors ◽  
Potential Use

Sentinel lymph node detection (SLND) is rapidly entering common practice in the management of patients with tumors. The introduction of mannose molecules to 99mTc-labeled dextrans, so far, showed that the sentinel node could trap these agents due to their recognition by the mannose receptors of lymph node macrophages. The current study aimed to synthesize, characterize, and biologically evaluate a series of mannosylated dextran derivatives labeled with 99mTc for potential use in SLND. The compounds were designed to have a dextran with a molecular weight of 10–500 kDa as a backbone, S-derivatized cysteines, efficient SNO chelators, and mannose moieties for binding to mannose receptors. They were successfully synthesized, thoroughly characterized using NMR techniques, and labeled with the fac-[99mTc(CO)3]+ synthon. Labeling with high yields and radiochemical purities was achieved with all derivatives. In vivo biodistribution and imaging studies demonstrated high uptake in the first lymph node and low uptakes in the following node and confirmed the ability to visualize the SLN. Among the compounds studied, 99mTc-D75CM demonstrated the most attractive biological features, and in combination with the high radiochemical yield and stability of the compound, its further evaluation as a new radiopharmaceutical for sentinel lymph node detection was justified.

scholarly journals Optimising magnetic sentinel lymph node biopsy in an in vivo porcine model

2015 ◽  
Vol 11 (4) ◽  
pp. 993-1002 ◽  
Author(s):  
Muneer Ahmed ◽  
Bauke Anninga ◽  
Joost J. Pouw ◽  
Suzan Vreemann ◽  
Mirjam Peek ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Porcine Model ◽  
Lymph Node Biopsy ◽  
Node Biopsy
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