scholarly journals Bright and stable near-infrared Pluronic–silica nanoparticles as contrast agents for in vivo optical imaging

2016 ◽  
Vol 4 (33) ◽  
pp. 5560-5566 ◽  
Author(s):  
Lesan Yan ◽  
Huiquan Wang ◽  
Anqi Zhang ◽  
Calvin Zhao ◽  
Yongping Chen ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Contrast Agents ◽  
Optical Imaging ◽  
Silica Nanoparticles ◽  
Near Infrared ◽  
Circulation Time ◽  
In Vivo Optical Imaging

The IR780@NPs exhibited excellent characteristics for in vivo imaging with a long circulation time and high retention in tumor and sentinel lymph node.

scholarly journals Role of Fluorophore Charge on the In Vivo Optical Imaging Properties of Near-Infrared Cyanine Dye/Monoclonal Antibody Conjugates

2015 ◽  
Vol 27 (2) ◽  
pp. 404-413 ◽  
Author(s):  
Kazuhide Sato ◽  
Alexander P. Gorka ◽  
Tadanobu Nagaya ◽  
Megan S. Michie ◽  
Roger R. Nani ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Optical Imaging ◽  
Near Infrared ◽  
Cyanine Dye ◽  
Antibody Conjugates ◽  
Imaging Properties ◽  
In Vivo Optical Imaging

scholarly journals Shortwave Infrared Imaging with J-Aggregates Stabilized in Hollow Mesoporous Silica Nanoparticles

2018 ◽  
Author(s):  
Wei Chen ◽  
ChiAn Cheng ◽  
Emily Cosco ◽  
Shyam Ramakrishnan ◽  
Jakob Lingg ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Contrast Agents ◽  
Silica Nanoparticles ◽  
Near Infrared ◽  
Infrared Imaging ◽  
Mesoporous Silica Nanoparticles ◽  
J Aggregates ◽  
Hollow Mesoporous Silica ◽  
Shortwave Infrared

Tissue is translucent to shortwave infrared (SWIR) light, rendering optical imaging superior in this region. However, the widespread use of optical SWIR imaging has been limited, in part, by the lack of bright, biocompatible contrast agents that absorb and emit light above 1000 nm. J-aggregation offers a means to transform stable, near-infrared (NIR) fluorophores into red-shifted SWIR contrast agents. Here we demonstrate that hollow mesoporous silica nanoparticles (HMSNs) can template the J-aggregation of NIR fluorophore IR-140 to result in nanomaterials that absorb and emit SWIR light. The J-aggregates inside PEGylated HMSNs are stable for multiple weeks in buffer and enable high resolution imaging <i>in vivo</i>with 980 nm excitation.

scholarly journals Near-Infrared Fluorescent Nanoprobes for in Vivo Optical Imaging

Nanomaterials ◽  
2012 ◽  
Vol 2 (2) ◽  
pp. 92-112 ◽  
Author(s):  
Chai-Hoon Quek ◽  
Kam W. Leong
Keyword(s):  
Optical Imaging ◽  
Near Infrared ◽  
In Vivo Optical Imaging

scholarly journals Near-infrared-emissive polymersomes: Self-assembled soft matter for in vivo optical imaging

2005 ◽  
Vol 102 (8) ◽  
pp. 2922-2927 ◽  
Author(s):  
P. P. Ghoroghchian ◽  
P. R. Frail ◽  
K. Susumu ◽  
D. Blessington ◽  
A. K. Brannan ◽  
...  
Keyword(s):  
Optical Imaging ◽  
Soft Matter ◽  
Near Infrared ◽  
Self Assembled ◽  
In Vivo Optical Imaging

Synthesis and evaluation of curcumin-based near-infrared fluorescent probes for the in vivo optical imaging of amyloid-β plaques

2021 ◽  
pp. 105167
Author(s):  
Yong Dae Park ◽  
Mayank Kinger ◽  
Changho Min ◽  
Sang Yeob Lee ◽  
Youngjoo Byun ◽  
...  
Keyword(s):  
Optical Imaging ◽  
Fluorescent Probes ◽  
Near Infrared ◽  
Amyloid Β ◽  
In Vivo Optical Imaging

scholarly journals Organic Alternatives to Quantum Dots for Intraoperative Near-Infrared Fluorescent Sentinel Lymph Node Mapping

2005 ◽  
Vol 4 (3) ◽  
pp. 153535002005051 ◽  
Author(s):  
Shunsuke Ohnishi ◽  
Stephen J. Lomnes ◽  
Rita G. Laurence ◽  
Andrew Gogbashian ◽  
Giuliano Mariani ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Contrast Agents ◽  
Clinical Studies ◽  
Near Infrared ◽  
Sentinel Lymph Node Mapping ◽  
Lymph Node Mapping ◽  
Advantages And Disadvantages

Intraoperative near-infrared (NIR) fluorescence imaging provides the surgeon with real-time image guidance during cancer and other surgeries. We have previously reported the use of NIR fluorescent quantum dots (QDs) for sentinel lymph node (SLN) mapping. However, because of concerns over potential toxicity, organic alternatives to QDs will be required for initial clinical studies. We describe a family of 800 nm organic heptamethine indocyanine-based contrast agents for SLN mapping spanning a spectrum from 775 Da small molecules to 7 MDa nanocolloids. We provide a detailed characterization of the optical and physical properties of these contrast agents and discuss the advantages and disadvantages of each. We present robust methods for the covalent conjugation, purification, and characterization of proteins with tetra-sulfonated heptamethine indocyanines, including mass spectroscopic site mapping of highly substituted molecules. One contrast agent, NIR fluorescent human serum albumin (HSA800), emerged as the molecule with the best overall performance with respect to entry to lymphatics, flow to the SLN, retention in the SLN, fluorescence yield and reproducibility. This preclinical study, performed on large animals approaching the size of humans, should serve as a foundation for future clinical studies.

Synthesis of chitosan-coated near-infrared layered double hydroxide nanoparticles for in vivo optical imaging

2012 ◽  
Vol 22 (12) ◽  
pp. 5503 ◽  
Author(s):  
Pei-Ru Wei ◽  
Shih-Hsun Cheng ◽  
Wei-Neng Liao ◽  
Kun-Che Kao ◽  
Ching-Feng Weng ◽  
...  
Keyword(s):  
Optical Imaging ◽  
Layered Double Hydroxide ◽  
Near Infrared ◽  
Double Hydroxide ◽  
In Vivo Optical Imaging ◽  
Layered Double Hydroxide Nanoparticles
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