Metabolic remodeling of the human red blood cell membrane measured by quantitative phase microscopy

2011 ◽  
Author(s):  
YongKeun Park ◽  
Catherine Best ◽  
Thorsten Auth ◽  
Nir S. Gov ◽  
Samuel Safran ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Quantitative Phase ◽  
Phase Microscopy ◽  
Red Blood Cell Membrane ◽  
Quantitative Phase Microscopy ◽  
Metabolic Remodeling

scholarly journals Imaging red blood cell dynamics by quantitative phase microscopy

2008 ◽  
Vol 41 (1) ◽  
pp. 10-16 ◽  
Author(s):  
Gabriel Popescu ◽  
YoungKeun Park ◽  
Wonshik Choi ◽  
Ramachandra R. Dasari ◽  
Michael S. Feld ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Dynamics ◽  
Quantitative Phase ◽  
Phase Microscopy ◽  
Quantitative Phase Microscopy

scholarly journals Metabolic remodeling of the human red blood cell membrane

2010 ◽  
Vol 107 (4) ◽  
pp. 1289-1294 ◽  
Author(s):  
Y. Park ◽  
C. A. Best ◽  
T. Auth ◽  
N. S. Gov ◽  
S. A. Safran ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Red Blood Cell Membrane ◽  
Metabolic Remodeling

Red blood cell three-dimensional morphometry by quantitative phase microscopy

2015 ◽  
Author(s):  
F. Merola ◽  
P. Memmolo ◽  
L. Miccio ◽  
O. Gennari ◽  
M. Mugnano ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Three Dimensional ◽  
Quantitative Phase ◽  
Phase Microscopy ◽  
Quantitative Phase Microscopy

scholarly journals Red Blood Cell Membrane-Camouflaged Tedizolid Phosphate-Loaded PLGA Nanoparticles for Bacterial-Infection Therapy

Pharmaceutics ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 99
Author(s):  
Xinyi Wu ◽  
Yichen Li ◽  
Faisal Raza ◽  
Xuerui Wang ◽  
Shulei Zhang ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Cell Membrane ◽  
Blood Cell ◽  
Sustained Release ◽  
Delivery System ◽  
Red Blood Cell ◽  
Multiple Drug Resistance ◽  
Plga Nanoparticles ◽  
Multiple Drug ◽  
Red Blood Cell Membrane

Multiple drug resistance (MDR) in bacterial infections is developed with the abuse of antibiotics, posing a severe threat to global health. Tedizolid phosphate (TR-701) is an efficient prodrug of tedizolid (TR-700) against gram-positive bacteria, including methicillin-sensitive staphylococcus aureus (MSSA) and methicillin-resistant staphylococcus aureus (MRSA). Herein, a novel drug delivery system: Red blood cell membrane (RBCM) coated TR-701-loaded polylactic acid-glycolic acid copolymer (PLGA) nanoparticles (RBCM-PLGA-TR-701NPs, RPTR-701Ns) was proposed. The RPTR-701Ns possessed a double-layer core-shell structure with 192.50 ± 5.85 nm in size, an average encapsulation efficiency of 36.63% and a 48 h-sustained release in vitro. Superior bio-compatibility was confirmed with red blood cells (RBCs) and HEK 293 cells. Due to the RBCM coating, RPTR-701Ns on one hand significantly reduced phagocytosis by RAW 264.7 cells as compared to PTR-701Ns, showing an immune escape effect. On the other hand, RPTR-701Ns had an advanced exotoxins neutralization ability, which helped reduce the damage of MRSA exotoxins to RBCs by 17.13%. Furthermore, excellent in vivo bacteria elimination and promoted wound healing were observed of RPTR-701Ns with a MRSA-infected mice model without causing toxicity. In summary, the novel delivery system provides a synergistic antibacterial treatment of both sustained release and bacterial toxins absorption, facilitating the incorporation of TR-701 into modern nanotechnology.

scholarly journals Direct Measurement of the Area Expansion and Shear Moduli of the Human Red Blood Cell Membrane Skeleton

2001 ◽  
Vol 81 (1) ◽  
pp. 43-56 ◽  
Author(s):  
Guillaume Lenormand ◽  
Sylvie Hénon ◽  
Alain Richert ◽  
Jacqueline Siméon ◽  
François Gallet
Keyword(s):  
Cell Membrane ◽  
Blood Cell ◽  
Direct Measurement ◽  
Red Blood Cell ◽  
Membrane Skeleton ◽  
Shear Moduli ◽  
Red Blood Cell Membrane ◽  
Area Expansion
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