In vivo detection of osteoarthritis in the hand with three-dimensional photoacoustic tomography

2010 ◽  
Author(s):  
Yao Sun ◽  
Eric Sobel ◽  
Huabei Jiang
Keyword(s):  
Three Dimensional ◽  
Photoacoustic Tomography ◽  
In Vivo Detection

scholarly journals Comparison of Piezoelectric and Optical Projection Imaging for Three-Dimensional In Vivo Photoacoustic Tomography

2019 ◽  
Vol 5 (1) ◽  
pp. 15 ◽  
Author(s):  
Robert Nuster ◽  
Günther Paltauf
Keyword(s):  
Acoustic Field ◽  
Back Propagation ◽  
Three Dimensional ◽  
Sensor Arrays ◽  
Optical Data ◽  
Acquisition Time ◽  
Photoacoustic Tomography ◽  
Light Illumination ◽  
Optical Setup

Ultrasound sensor arrays for photoacoustic tomography (PAT) are investigated that create line projections of the pressure generated in an object by pulsed light illumination. Projections over a range of viewing angles enable the reconstruction of a three-dimensional image. Two line-integrating arrays are compared in this study for the in vivo imaging of vasculature, a piezoelectric array, and a camera-based setup that captures snapshots of the acoustic field emanating from the sample. An array consisting of 64 line-shaped sensors made of piezoelectric polymer film, which was arranged on a half-cylindrical area, was used to acquire spatiotemporal data from a human finger. The optical setup used phase contrast to visualize the acoustic field generated in the leg of a mouse after a selected delay time. Time-domain back projection and frequency-domain back propagation were used for image reconstruction from the piezoelectric and optical data, respectively. The comparison yielded an about threefold higher resolution for the optical setup and an about 13-fold higher sensitivity of the piezoelectric array. Due to the high density of data in the camera images, the optical technique gave images without streak artifacts, which were visible in the piezo array images due to the discrete detector positions. Overall, both detection concepts are suited for almost real-time projection imaging and three-dimensional imaging with a data acquisition time of less than a minute without averaging, which was limited by the repetition rate of the laser.

scholarly journals In vivo three-dimensional photoacoustic tomography of a whole mouse head

2006 ◽  
Vol 31 (16) ◽  
pp. 2453 ◽  
Author(s):  
Kwang Hyun Song ◽  
George Stoica ◽  
Lihong V. Wang
Keyword(s):  
Three Dimensional ◽  
Photoacoustic Tomography

In vivo detection of damage in multiple sclerosis cortex and cortical lesions using NODDI

2021 ◽  
pp. jnnp-2021-327803
Author(s):  
Paolo Preziosa ◽  
Elisabetta Pagani ◽  
Raffaello Bonacchi ◽  
Laura Cacciaguerra ◽  
Andrea Falini ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Volume Fraction ◽  
Three Dimensional ◽  
Progressive Multiple Sclerosis ◽  
Cortical Lesions ◽  
Clinical Phenotypes ◽  
Density Reduction ◽  
In Vivo Detection ◽  
D Values

ObjectiveTo characterise in vivo the microstructural abnormalities of multiple sclerosis (MS) normal-appearing (NA) cortex and cortical lesions (CLs) and their relations with clinical phenotypes and disability using neurite orientation dispersion and density imaging (NODDI).MethodsOne hundred and seventy-two patients with MS (101 relapsing–remitting multiple sclerosis (RRMS), 71 progressive multiple sclerosis (PMS)) and 62 healthy controls (HCs) underwent a brain 3T MRI. Brain cortex and CLs were segmented from three-dimensional T1-weighted and double inversion recovery sequences. Using NODDI on diffusion-weighted sequence, intracellular volume fraction (ICV_f) and Orientation Dispersion Index (ODI) were assessed in NA cortex and CLs with default or optimised parallel diffusivity for the cortex (D//=1.7 or 1.2 µm2/ms, respectively).ResultsThe NA cortex of patients with MS had significantly lower ICV_f versus HCs’ cortex with both D// values (false discovery rate (FDR)-p <0.001). CLs showed significantly decreased ICV_f and ODI versus NA cortex of both HCs and patients with MS with both D// values (FDR-p ≤0.008). Patients with PMS versus RRMS had significantly decreased NA cortex ICV_f and ODI (FDR-p=0.050 and FDR-p=0.032) with only D//=1.7 µm2/ms. No CL microstructural differences were found between MS clinical phenotypes. MS NA cortex ICV_f and ODI were significantly correlated with disease duration, clinical disability, lesion burden and global and regional brain atrophy (r from −0.51 to 0.71, FDR-p from <0.001 to 0.045).ConclusionsA significant neurite loss occurs in MS NA cortex. CLs show a further neurite density reduction and a reduced ODI suggesting a simplification of neurite complexity. NODDI is relevant to investigate in vivo the heterogeneous pathology affecting the MS cortex.

Digital artery deformation on movement of the proximal interphalangeal joint

2018 ◽  
Vol 44 (2) ◽  
pp. 187-195
Author(s):  
Susumu Saito ◽  
Ryoma Bise ◽  
Aya Yoshikawa ◽  
Hiroyuki Sekiguchi ◽  
Itaru Tsuge ◽  
...  
Keyword(s):  
Index Finger ◽  
Three Dimensional ◽  
Proximal Interphalangeal Joint ◽  
Interphalangeal Joint ◽  
Three Dimensions ◽  
Morphological Data ◽  
Photoacoustic Tomography ◽  
Digital Artery ◽  
Specific Mechanism

This study aimed to characterize in vivo human digital arteries in three-dimensions using photoacoustic tomography in order to understand the specific mechanism underlying arterial deformation associated with movement of the proximal interphalangeal joint. Three-dimensional morphological data were obtained on the radialis indicis artery (radial artery of the index finger) at different angles of the joint. The association between increased curvature of the deformation and the anatomical region was assessed. Characteristic morphological deformations in areas of major deformation were determined. The deformation of the artery was characterized by three consecutive curves in juxta-articular regions, which were particularly noticeable when the joint was flexed at an angle of ≥ 60°. The change in the curvature of the deformation during 30°–90° of flexion was lower in middle-aged individuals than in young individuals. Better understanding of the mechanism underlying deformation of the digital arteries may contribute to advancements in flap procedures and rehabilitation strategies after digital artery repair.

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