scholarly journals A Unique Recombinant Fluoroprobe Targeting Activated Platelets Allows In Vivo Detection of Arterial Thrombosis and Pulmonary Embolism Using a Novel Three-Dimensional Fluorescence Emission Computed Tomography (FLECT) Technology

Theranostics ◽  
2017 ◽  
Vol 7 (5) ◽  
pp. 1047-1061 ◽  
Author(s):  
Bock Lim ◽  
Yu Yao ◽  
Alex Lin-i Huang ◽  
May Lin Yap ◽  
Ulrike Flierl ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Pulmonary Embolism ◽  
Arterial Thrombosis ◽  
Three Dimensional ◽  
Fluorescence Emission ◽  
Emission Computed Tomography ◽  
Activated Platelets ◽  
Emission Computed ◽  
In Vivo Detection

Development of particle induced X-ray emission-computed tomography in Takasaki Advanced Radiation Research Institute, Japan Atomic Energy Agency

2015 ◽  
Vol 25 (03n04) ◽  
pp. 147-152 ◽  
Author(s):  
Takahiro Satoh
Keyword(s):  
Computed Tomography ◽  
Three Dimensional ◽  
Major Elements ◽  
Atomic Energy ◽  
Emission Computed Tomography ◽  
X Rays ◽  
Japan Atomic Energy Agency ◽  
Energy Agency ◽  
X Ray ◽  
Emission Computed

A new micro-particle induced X-ray emission-computed tomography (PIXE-CT) system was developed at Takasaki Ion Accelerators for Advanced Radiation Application in Japan Atomic Energy Agency. In this system, scanning transmission ion microscopy-CT was performed as well as PIXE-CT for three-dimensional (3D) measurement of major elements' distributions, which are required for corrections of X-ray yields due to energy losses of projectiles and absorption of X-rays. Moreover, maximum likelihood expectation maximization algorithm has been introduced to image reconstruction because higher spatial resolution can be obtained even with less X-ray yields. Consequently, 3D distribution of trace elements in a minute biological cell less than 100 μm has been successfully obtained.

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